Perspective:

Gregg L. Semenza

Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1 Expression
Mol Pharmacol 2006 70: 1841-1843. Published online September 25, 2006; 10.1124/mol.106.031062 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communications:

Zoltán Benyó, Andreas Gille, Clare L. Bennett, Björn E. Clausen, and Stefan Offermanns

Nicotinic Acid-Induced Flushing Is Mediated by Activation of Epidermal Langerhans Cells
Mol Pharmacol 2006 70: 1844-1849. Published online September 28, 2006; 10.1124/mol.106.030833 [Abstract] [Full Text] [PDF]  

Stephen J. Getting, Connie W. Lam, Giovanna Leoni, Felicity N. E. Gavins, Paolo Grieco, and Mauro Perretti

[D-Trp⁸]--Melanocyte-Stimulating Hormone Exhibits Anti-Inflammatory Efficacy in Mice Bearing a Nonfunctional MC1R (Recessive Yellow e/e Mouse)
Mol Pharmacol 2006 70: 1850-1855. Published online September 7, 2006; 10.1124/mol.106.028878 [Abstract] [Full Text] [PDF]  

Articles:

Ji-Hong Lim, Jong-Wan Park, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson, and Yang-Sook Chun

Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1
Mol Pharmacol 2006 70: 1856-1865. Published online August 28, 2006; 10.1124/mol.106.028076 [Abstract] [Full Text] [PDF] [Data Supplement]   

Donnette A. Dabydeen, James C. Burnett, Ruoli Bai, Pascal Verdier-Pinard, Sarah J. H. Hickford, George R. Pettit, John W. Blunt, Murray H. G. Munro, Rick Gussio, and Ernest Hamel

Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin
Mol Pharmacol 2006 70: 1866-1875. Published online August 29, 2006; 10.1124/mol.106.026641 [Abstract] [Full Text] [PDF]  

Giuseppe Faraco, Tristano Pancani, Laura Formentini, Paolo Mascagni, Gianluca Fossati, Flavio Leoni, Flavio Moroni, and Alberto Chiarugi

Pharmacological Inhibition of Histone Deacetylases by Suberoylanilide Hydroxamic Acid Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain
Mol Pharmacol 2006 70: 1876-1884. Published online August 31, 2006; 10.1124/mol.106.027912 [Abstract] [Full Text] [PDF]  

Ziva D. Cooper, Diwahar Narasimhan, Roger K. Sunahara, Pawel Mierzejewski, Emily M. Jutkiewicz, Nicholas A. Larsen, Ian A. Wilson, Donald W. Landry, and James H. Woods

Rapid and Robust Protection against Cocaine-Induced Lethality in Rats by the Bacterial Cocaine Esterase
Mol Pharmacol 2006 70: 1885-1891. Published online September 12, 2006; 10.1124/mol.106.025999 [Abstract] [Full Text] [PDF]  

Mette M. Rosenkilde, Ralf David, Ilka Oerlecke, Tau Benned-Jensen, Ulf Geumann, Anette G. Beck-Sickinger, and Thue W. Schwartz

Conformational Constraining of Inactive and Active States of a Seven Transmembrane Receptor by Metal Ion Site Engineering in the Extracellular End of Transmembrane Segment V
Mol Pharmacol 2006 70: 1892-1901. Published online September 13, 2006; 10.1124/mol.106.027425 [Abstract] [Full Text] [PDF]  

Xueqing Liu and Colin Jefcoate

2,3,7,8-Tetrachlorodibenzo-p-dioxin and Epidermal Growth Factor Cooperatively Suppress Peroxisome Proliferator-Activated Receptor-1 Stimulation and Restore Focal Adhesion Complexes during Adipogenesis: Selective Contributions of Src, Rho, and Erk Distinguish These Overlapping Processes in C3H10T1/2 Cells
Mol Pharmacol 2006 70: 1902-1915. Published online September 13, 2006; 10.1124/mol.106.026534 [Abstract] [Full Text] [PDF]  

Tetsushi Furukawa, Chang-Xi Bai, Asami Kaihara, Eri Ozaki, Takashi Kawano, Yutaka Nakaya, Muhammad Awais, Moritoshi Sato, Yoshio Umezawa, and Junko Kurokawa

Ginsenoside Re, a Main Phytosterol of Panax ginseng, Activates Cardiac Potassium Channels via a Nongenomic Pathway of Sex Hormones
Mol Pharmacol 2006 70: 1916-1924. Published online September 19, 2006; 10.1124/mol.106.028134 [Abstract] [Full Text] [PDF]  

Franck Rencurel, Marc Foretz, Michel R. Kaufmann, Deborah Stroka, Renate Looser, Isabelle Leclerc, Gabriela da Silva Xavier, Guy A. Rutter, Benoit Viollet, and Urs A. Meyer

Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver
Mol Pharmacol 2006 70: 1925-1934. Published online September 20, 2006; 10.1124/mol.106.029421 [Abstract] [Full Text] [PDF]  

Michaël R. Paillasse, Céline Deraeve, Philippe de Medina, Loubna Mhamdi, Gilles Favre, Marc Poirot, and Sandrine Silvente-Poirot

Insights into the Cholecystokinin 2 Receptor Binding Site and Processes of Activation
Mol Pharmacol 2006 70: 1935-1945. Published online September 22, 2006; 10.1124/mol.106.029967 [Abstract] [Full Text] [PDF]  

Chung-Hang Leung, Susan P. Grill, Wing Lam, Wenli Gao, Han-Dong Sun, and Yung-Chi Cheng

Eriocalyxin B Inhibits Nuclear Factor-B Activation by Interfering with the Binding of Both p65 and p50 to the Response Element in a Noncompetitive Manner
Mol Pharmacol 2006 70: 1946-1955. Published online August 29, 2006; 10.1124/mol.106.028480 [Abstract] [Full Text] [PDF]  

Michael R. Braden, Jason C. Parrish, John C. Naylor, and David E. Nichols

Molecular Interaction of Serotonin 5-HT_2A Receptor Residues Phe339^(6.51) and Phe340^(6.52) with Superpotent N-Benzyl Phenethylamine Agonists
Mol Pharmacol 2006 70: 1956-1964. Published online September 25, 2006; 10.1124/mol.106.028720 [Abstract] [Full Text] [PDF]  

Xin-Yan Pei, Weiqun Li, Yun Dai, Paul Dent, and Steven Grant

Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hydroxystaurosporine-Induced Apoptosis in Human Multiple Myeloma Cells
Mol Pharmacol 2006 70: 1965-1973. Published online August 29, 2006; 10.1124/mol.106.028373 [Abstract] [Full Text] [PDF]  

Tracy A. Spalding, Jian-Nong Ma, Thomas R. Ott, Mikael Friberg, Abhishek Bajpai, Stefania Risso Bradley, Robert E. Davis, Mark R. Brann, and Ethan S. Burstein

Structural Requirements of Transmembrane Domain 3 for Activation by the M₁ Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation
Mol Pharmacol 2006 70: 1974-1983. Published online September 7, 2006; 10.1124/mol.106.024901 [Abstract] [Full Text] [PDF]  

Debbie L. Hay, George Christopoulos, Arthur Christopoulos, and Patrick M. Sexton

Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Receptor Activity Modifying Protein 1
Mol Pharmacol 2006 70: 1984-1991. Published online September 7, 2006; 10.1124/mol.106.027953 [Abstract] [Full Text] [PDF]  

Xiaoqiu Liu, Shu Qiang Sun, Aviv Hassid, and Rennolds S. Ostrom

cAMP Inhibits Transforming Growth Factor--Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Cardiac Fibroblasts
Mol Pharmacol 2006 70: 1992-2003. Published online September 7, 2006; 10.1124/mol.106.028951 [Abstract] [Full Text] [PDF]  

Katarzyna A. Cieslik, Wu-Guo Deng, and Kenneth K. Wu

Essential Role of C-Rel in Nitric-Oxide Synthase-2 Transcriptional Activation: Time-Dependent Control by Salicylate
Mol Pharmacol 2006 70: 2004-2014. Published online September 8, 2006; 10.1124/mol.106.026054 [Abstract] [Full Text] [PDF]  

Pablo Artigas, Subhi J. Al'Aref, E. Ashley Hobart, Laín F. Díaz, Masayuki Sakaguchi, Samuel Straw, and Olaf S. Andersen

2,3-Butanedione Monoxime Affects Cystic Fibrosis Transmembrane Conductance Regulator Channel Function through Phosphorylation-Dependent and Phosphorylation-Independent Mechanisms: The Role of Bilayer Material Properties
Mol Pharmacol 2006 70: 2015-2026. Published online September 11, 2006; 10.1124/mol.106.026070 [Abstract] [Full Text] [PDF] [Data Supplement]   

Delphine S. Dupuis, Dinko Relkovic, Loic Lhuillier, Johannes Mosbacher, and Klemens Kaupmann

Point Mutations in the Transmembrane Region of GABA_B2 Facilitate Activation by the Positive Modulator N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the Absence of the GABA_B1 Subunit
Mol Pharmacol 2006 70: 2027-2036. Published online September 11, 2006; 10.1124/mol.106.028183 [Abstract] [Full Text] [PDF]  

Masashi Kishi and Joe Henry Steinbach

Role of the Agonist Binding Site in Up-Regulation of Neuronal Nicotinic 42 Receptors
Mol Pharmacol 2006 70: 2037-2044. Published online September 11, 2006; 10.1124/mol.106.029298 [Abstract] [Full Text] [PDF]  

Deming Gong, Jun Lu, Xiuyin Chen, Soon Y. Choong, Shaoping Zhang, Yih-Kai Chan, Sarah Glyn-Jones, Gregory D. Gamble, Anthony R. J. Phillips, and Garth J. S. Cooper

Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats
Mol Pharmacol 2006 70: 2045-2051. Published online September 14, 2006; 10.1124/mol.106.028605 [Abstract] [Full Text] [PDF]  

N. Lenkey, R. Karoly, J. P. Kiss, B. K. Szasz, E. S. Vizi, and A. Mike

The Mechanism of Activity-Dependent Sodium Channel Inhibition by the Antidepressants Fluoxetine and Desipramine
Mol Pharmacol 2006 70: 2052-2063. Published online September 19, 2006; 10.1124/mol.106.026419 [Abstract] [Full Text] [PDF]  

John McDaid, Martin P. Graham, and T. Celeste Napier

Methamphetamine-Induced Sensitization Differentially Alters pCREB and FosB throughout the Limbic Circuit of the Mammalian Brain
Mol Pharmacol 2006 70: 2064-2074. Published online September 1, 2006; 10.1124/mol.106.023051 [Abstract] [Full Text] [PDF]  

Takahiro Iwamoto and Satomi Kita

YM-244769, a Novel Na⁺/Ca²⁺ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal Cell Damage
Mol Pharmacol 2006 70: 2075-2083. Published online September 14, 2006; 10.1124/mol.106.028464 [Abstract] [Full Text] [PDF]  

Joanna E. Chivers, Wei Gong, Elizabeth M. King, Joachim Seybold, Judith C. Mak, Louise E. Donnelly, Neil S. Holden, and Robert Newton

Analysis of the Dissociated Steroid RU24858 Does Not Exclude a Role for Inducible Genes in the Anti-Inflammatory Actions of Glucocorticoids
Mol Pharmacol 2006 70: 2084-2095. Published online September 20, 2006; 10.1124/mol.106.025841 [Abstract] [Full Text] [PDF] [Data Supplement]   

Brett D. Hollingshead, Rushang D. Patel, and Gary H. Perdew

Endogenous Hepatic Expression of the Hepatitis B Virus X-Associated Protein 2 Is Adequate for Maximal Association with Aryl Hydrocarbon Receptor-90-kDa Heat Shock Protein Complexes
Mol Pharmacol 2006 70: 2096-2107. Published online September 20, 2006; 10.1124/mol.106.029215 [Abstract] [Full Text] [PDF]  

Jun Fang, Quintin J. Quinones, Trevor L. Holman, Michael J. Morowitz, Qun Wang, Huaqing Zhao, Frank Sivo, John M. Maris, and Miriam L. Wahl

The H⁺-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma
Mol Pharmacol 2006 70: 2108-2115. Published online September 25, 2006; 10.1124/mol.106.026245 [Abstract] [Full Text] [PDF]  

G. Giordano, C. C. White, L. A. McConnachie, C. Fernandez, T. J. Kavanagh, and L. G. Costa

Neurotoxicity of Domoic Acid in Cerebellar Granule Neurons in a Genetic Model of Glutathione Deficiency
Mol Pharmacol 2006 70: 2116-2126. Published online September 25, 2006; 10.1124/mol.106.027748 [Abstract] [Full Text] [PDF]  

Maciej J. Zamek-Gliszczynski, Ken-ichi Nezasa, Xianbin Tian, J. Cory Kalvass, Nita J. Patel, Thomas J. Raub, and Kim L. R. Brouwer

The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice
Mol Pharmacol 2006 70: 2127-2133. Published online September 7, 2006; 10.1124/mol.106.026955 [Abstract] [Full Text] [PDF]  

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