Perspective:

Jonathan M. Levenson

DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia
Mol Pharmacol 2007 71: 635-637. Published online December 19, 2006; 10.1124/mol.106.033266 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communication:

Jean-Claude Martel, Anne-Marie Ormière, Nathalie Leduc, Marie-Bernadette Assié, Didier Cussac, and Adrian Newman-Tancredi

Native Rat Hippocampal 5-HT_1A Receptors Show Constitutive Activity
Mol Pharmacol 2007 71: 638-643. Published online December 13, 2006; 10.1124/mol.106.029769 [Abstract] [Full Text] [PDF]  

Articles:

Marija Kundakovic, Ying Chen, Erminio Costa, and Dennis R. Grayson

DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes
Mol Pharmacol 2007 71: 644-653. Published online October 25, 2006; 10.1124/mol.106.030635 [Abstract] [Full Text] [PDF]  

Jing Wang, Jérôme Ruel, Sabine Ladrech, Christophe Bonny, Thomas R. van de Water, and Jean-Luc Puel

Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals
Mol Pharmacol 2007 71: 654-666. Published online November 28, 2006; 10.1124/mol.106.028936 [Abstract] [Full Text] [PDF]  

Björn Bauer, Anika M. S. Hartz, and David S. Miller

Tumor Necrosis Factor and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier
Mol Pharmacol 2007 71: 667-675. Published online November 28, 2006; 10.1124/mol.106.029512 [Abstract] [Full Text] [PDF]  

Richard J. Lewis, Christina I. Schroeder, Jenny Ekberg, Katherine J. Nielsen, Marion Loughnan, Linda Thomas, Denise A. Adams, Roger Drinkwater, David J. Adams, and Paul F. Alewood

Isolation and Structure-Activity of µ-Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels
Mol Pharmacol 2007 71: 676-685. Published online December 1, 2006; 10.1124/mol.106.028225 [Abstract] [Full Text] [PDF]  

Michael Holinstat, Bryan Voss, Matthew L. Bilodeau, and Heidi E. Hamm

Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
Mol Pharmacol 2007 71: 686-694. Published online December 6, 2006; 10.1124/mol.106.029371 [Abstract] [Full Text] [PDF] [Data Supplement]   

Sandra Liekens, Sofie Gijsbers, Els Vanstreels, Dirk Daelemans, Erik De Clercq, and Sigrid Hatse

The Nucleotide Analog Cidofovir Suppresses Basic Fibroblast Growth Factor (FGF2) Expression and Signaling and Induces Apoptosis in FGF2-Overexpressing Endothelial Cells
Mol Pharmacol 2007 71: 695-703. Published online December 7, 2006; 10.1124/mol.106.026559 [Abstract] [Full Text] [PDF]  

Mélanie Frauli, Nadia Hubert, Stephan Schann, Nicolas Triballeau, Hugues-Olivier Bertrand, Francine Acher, Pascal Neuville, Jean-Philippe Pin, and Laurent Prézeau

Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism
Mol Pharmacol 2007 71: 704-712. Published online December 13, 2006; 10.1124/mol.106.030254 [Abstract] [Full Text] [PDF]  

Randy M. Wadkins, Janice L. Hyatt, Carol C. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Craig E. Wheelock, Paul D. Jones, Bruce D. Hammock, and Philip M. Potter

Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds
Mol Pharmacol 2007 71: 713-723. Published online December 13, 2006; 10.1124/mol.105.021683 [Abstract] [Full Text] [PDF]  

Qiaolin Deng, Joseph A. Clemas, Gary Chrebet, Paul Fischer, Jeffrey J. Hale, Zhen Li, Sander G. Mills, James Bergstrom, Suzanne Mandala, Ralph Mosley, and Stephen A. Parent

Identification of Leu276 of the S1P₁ Receptor and Phe263 of the S1P₃ Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
Mol Pharmacol 2007 71: 724-735. Published online December 14, 2006; 10.1124/mol.106.029223 [Abstract] [Full Text] [PDF]  

M. Gomez-Lazaro, M. F. Galindo, R. M. Melero-Fernandez de Mera, F. J. Fernandez-Gómez, C. G. Concannon, M. F. Segura, J. X. Comella, J. H. M. Prehn, and J. Jordan

Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate
Mol Pharmacol 2007 71: 736-743. Published online December 15, 2006; 10.1124/mol.106.030718 [Abstract] [Full Text] [PDF]  

M. Cecilia Caino, Jose L. Oliva, Hao Jiang, Trevor M. Penning, and Marcelo G. Kazanietz

Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G₂/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells
Mol Pharmacol 2007 71: 744-750. Published online November 17, 2006; 10.1124/mol.106.032078 [Abstract] [Full Text] [PDF]  

Ying Wang, Tip W. Loo, M. Claire Bartlett, and David M. Clarke

Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones
Mol Pharmacol 2007 71: 751-758. Published online November 28, 2006; 10.1124/mol.106.029926 [Abstract] [Full Text] [PDF]  

Xi-Ping Huang and John Ellis

Mutational Disruption of a Conserved Disulfide Bond in Muscarinic Acetylcholine Receptors Attenuates Positive Homotropic Cooperativity between Multiple Allosteric Sites and Has Subtype-Dependent Effects on the Affinities of Muscarinic Allosteric Ligands
Mol Pharmacol 2007 71: 759-768. Published online November 28, 2006; 10.1124/mol.106.028944 [Abstract] [Full Text] [PDF]  

L. Tapia, A. Kuryatov, and J. Lindstrom

Ca²⁺ Permeability of the (4)₃(2)₂ Stoichiometry Greatly Exceeds That of (4)₂(2)₃ Human Acetylcholine Receptors
Mol Pharmacol 2007 71: 769-776. Published online November 28, 2006; 10.1124/mol.106.030445 [Abstract] [Full Text] [PDF]  

Hiroshi Tsuneki, Soushi Kobayashi, Kazue Takagi, Syota Kagawa, Masahiko Tsunoda, Masahiko Murata, Tadasu Matsuoka, Tsutomu Wada, Masayoshi Kurachi, Ikuko Kimura, and Toshiyasu Sasaoka

Novel G423S Mutation of Human 7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism
Mol Pharmacol 2007 71: 777-786. Published online November 28, 2006; 10.1124/mol.106.030866 [Abstract] [Full Text] [PDF]  

Petra Kempná, Gaby Hofer, Primus E. Mullis, and Christa E. Flück

Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2
Mol Pharmacol 2007 71: 787-798. Published online November 30, 2006; 10.1124/mol.106.028902 [Abstract] [Full Text] [PDF]  

Friederike Cuello, Andrew K. Snabaitis, Michael S. Cohen, Jack Taunton, and Metin Avkiran

Evidence for Direct Regulation of Myocardial Na⁺/H⁺ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to ₁-Adrenergic Stimulation
Mol Pharmacol 2007 71: 799-806. Published online December 1, 2006; 10.1124/mol.106.029900 [Abstract] [Full Text] [PDF]  

Guoyu Ling, Yuan Wei, and Xinxin Ding

Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation
Mol Pharmacol 2007 71: 807-816. Published online December 5, 2006; 10.1124/mol.106.031104 [Abstract] [Full Text] [PDF]  

Yuji Tanaka, Jonathan M. Maher, Chuan Chen, and Curtis D. Klaassen

Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice
Mol Pharmacol 2007 71: 817-825. Published online December 6, 2006; 10.1124/mol.106.029033 [Abstract] [Full Text] [PDF]  

Eric C. K. Siu and Rachel F. Tyndale

Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice
Mol Pharmacol 2007 71: 826-834. Published online December 7, 2006; 10.1124/mol.106.032086 [Abstract] [Full Text] [PDF]  

Y. Wei, J. M. Williams, C. Dipace, U. Sung, J. A. Javitch, A. Galli, and C. Saunders

Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca²⁺/Calmodulin-Dependent Kinase II-Dependent Mechanism
Mol Pharmacol 2007 71: 835-842. Published online December 12, 2006; 10.1124/mol.106.026351 [Abstract] [Full Text] [PDF]  

Guyllaume Coiret, Anne-Sophie Borowiec, Pascal Mariot, Halima Ouadid-Ahidouch, and Fabrice Matifat

The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells
Mol Pharmacol 2007 71: 843-851. Published online December 12, 2006; 10.1124/mol.106.028290 [Abstract] [Full Text] [PDF]  

Anja Zeller, Margarete Arras, Rachel Jurd, and Uwe Rudolph

Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital
Mol Pharmacol 2007 71: 852-859. Published online December 12, 2006; 10.1124/mol.106.030049 [Abstract] [Full Text] [PDF]  

Takushi Namba, Tatsuya Hoshino, Ken-ichiro Tanaka, Shinji Tsutsumi, Tomoaki Ishihara, Shinji Mima, Keitarou Suzuki, Satoshi Ogawa, and Tohru Mizushima

Up-Regulation of 150-kDa Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinoma Cells
Mol Pharmacol 2007 71: 860-870. Published online December 13, 2006; 10.1124/mol.106.027698 [Abstract] [Full Text] [PDF]  

Brante P. Sampey, David L. Carbone, Jonathan A. Doorn, Derek A. Drechsel, and Dennis R. Petersen

4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est–Like Protein-1-Activating Protein-1 Signal Transduction
Mol Pharmacol 2007 71: 871-883. Published online December 12, 2006; 10.1124/mol.106.029686 [Abstract] [Full Text] [PDF]  

J. A. Shimshoni, E. C. Dalton, A. Jenkins, S. Eyal, K. Ewan, R. S. B. Williams, N. Pessah, B. Yagen, A. J. Harwood, and M. Bialer

The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior
Mol Pharmacol 2007 71: 884-892. Published online December 13, 2006; 10.1124/mol.106.030601 [Abstract] [Full Text] [PDF]  

Allison A. Johnson, Christophe Marchand, Sachindra S. Patil, Roberta Costi, Roberto Di Santo, Terrence R. Burke, Jr., and Yves Pommier

Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays
Mol Pharmacol 2007 71: 893-901. Published online December 15, 2006; 10.1124/mol.106.030817 [Abstract] [Full Text] [PDF]  

Gaochao Tian, Dee Wilkins, and Clay W. Scott

Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca²⁺ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition
Mol Pharmacol 2007 71: 902-911. Published online December 15, 2006; 10.1124/mol.106.029868 [Abstract] [Full Text] [PDF]  

Kazuaki Yoshioka, Naotoshi Sugimoto, Noriko Takuwa, and Yoh Takuwa

Essential Role for Class II Phosphoinositide 3-kinase -Isoform in Ca²⁺-Induced, Rho- and Rho Kinase-Dependent Regulation of Myosin Phosphatase and Contraction in Isolated Vascular Smooth Muscle Cells
Mol Pharmacol 2007 71: 912-920. Published online December 19, 2006; 10.1124/mol.106.032599 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mohammed I. Al-Salabi, Lynsey J. M. Wallace, Alexandra Lüscher, Pascal Mäser, Denise Candlish, Boris Rodenko, Matthew K. Gould, Ishrat Jabeen, Sreekantan N. Ajith, and Harry P. de Koning

Molecular Interactions Underlying the Unusually High Adenosine Affinity of a Novel Trypanosoma brucei Nucleoside Transporter
Mol Pharmacol 2007 71: 921-929. Published online December 21, 2006; 10.1124/mol.106.031559 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mette M. Rosenkilde, Michael B. Andersen, Rie Nygaard, Thomas M. Frimurer, and Thue W. Schwartz

Activation of the CXCR3 Chemokine Receptor through Anchoring of a Small Molecule Chelator Ligand between TM-III, -IV, and -VI
Mol Pharmacol 2007 71: 930-941. Published online December 14, 2006; 10.1124/mol.106.030031 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ji-Hong Lim, Jong-Wan Park, Sung Joon Kim, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson, and Yang-Sook Chun

ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1 (HIF-1) Binding and Mediates HIF-1 Expression by Bafilomycin A1
Mol Pharmacol 2007 71: 942-948. Published online December 18, 2006; 10.1124/mol.106.030296 [Abstract] [Full Text] [PDF]  

Marie Eve Moreau, Marie-Thérèse Bawolak, Guillaume Morissette, Albert Adam, and François Marceau

Role of Nuclear Factor-B and Protein Kinase C Signaling in the Expression of the Kinin B₁ Receptor in Human Vascular Smooth Muscle Cells
Mol Pharmacol 2007 71: 949-956. Published online December 18, 2006; 10.1124/mol.106.030684 [Abstract] [Full Text] [PDF]  

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