Mol Pharm -- Table of Contents (71 [3])

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March 2007; 71 (3)   [Index by Author] [Cover Caption]

       Perspective

       Accelerated Communication

       Articles

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Perspective:

Jonathan M. Levenson: DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia
Mol Pharmacol 2007 71: 635-637. Published online December 19, 2006; 10.1124/mol.106.033266 [Abstract] [Full Text] [PDF] [Related Article]

Accelerated Communication:

Jean-Claude Martel, Anne-Marie Ormière, Nathalie Leduc, Marie-Bernadette Assié, Didier Cussac, and Adrian Newman-Tancredi: Native Rat Hippocampal 5-HT_1A Receptors Show Constitutive Activity
Mol Pharmacol 2007 71: 638-643. Published online December 13, 2006; 10.1124/mol.106.029769 [Abstract] [Full Text] [PDF]

Articles:

Marija Kundakovic, Ying Chen, Erminio Costa, and Dennis R. Grayson: DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes
Mol Pharmacol 2007 71: 644-653. Published online October 25, 2006; 10.1124/mol.106.030635 [Abstract] [Full Text] [PDF]

Jing Wang, Jérôme Ruel, Sabine Ladrech, Christophe Bonny, Thomas R. van de Water, and Jean-Luc Puel: Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals
Mol Pharmacol 2007 71: 654-666. Published online November 28, 2006; 10.1124/mol.106.028936 [Abstract] [Full Text] [PDF]

Björn Bauer, Anika M. S. Hartz, and David S. Miller: Tumor Necrosis Factor ${alpha}$ and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier
Mol Pharmacol 2007 71: 667-675. Published online November 28, 2006; 10.1124/mol.106.029512 [Abstract] [Full Text] [PDF]

Richard J. Lewis, Christina I. Schroeder, Jenny Ekberg, Katherine J. Nielsen, Marion Loughnan, Linda Thomas, Denise A. Adams, Roger Drinkwater, David J. Adams, and Paul F. Alewood: Isolation and Structure-Activity of µ-Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels
Mol Pharmacol 2007 71: 676-685. Published online December 1, 2006; 10.1124/mol.106.028225 [Abstract] [Full Text] [PDF]

Michael Holinstat, Bryan Voss, Matthew L. Bilodeau, and Heidi E. Hamm: Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
Mol Pharmacol 2007 71: 686-694. Published online December 6, 2006; 10.1124/mol.106.029371 [Abstract] [Full Text] [PDF] [Data Supplement] [Erratum]

Sandra Liekens, Sofie Gijsbers, Els Vanstreels, Dirk Daelemans, Erik De Clercq, and Sigrid Hatse: The Nucleotide Analog Cidofovir Suppresses Basic Fibroblast Growth Factor (FGF2) Expression and Signaling and Induces Apoptosis in FGF2-Overexpressing Endothelial Cells
Mol Pharmacol 2007 71: 695-703. Published online December 7, 2006; 10.1124/mol.106.026559 [Abstract] [Full Text] [PDF]

Mélanie Frauli, Nadia Hubert, Stephan Schann, Nicolas Triballeau, Hugues-Olivier Bertrand, Francine Acher, Pascal Neuville, Jean-Philippe Pin, and Laurent Prézeau: Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism
Mol Pharmacol 2007 71: 704-712. Published online December 13, 2006; 10.1124/mol.106.030254 [Abstract] [Full Text] [PDF]

Randy M. Wadkins, Janice L. Hyatt, Carol C. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Craig E. Wheelock, Paul D. Jones, Bruce D. Hammock, and Philip M. Potter: Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds
Mol Pharmacol 2007 71: 713-723. Published online December 13, 2006; 10.1124/mol.105.021683 [Abstract] [Full Text] [PDF]

Qiaolin Deng, Joseph A. Clemas, Gary Chrebet, Paul Fischer, Jeffrey J. Hale, Zhen Li, Sander G. Mills, James Bergstrom, Suzanne Mandala, Ralph Mosley, and Stephen A. Parent: Identification of Leu276 of the S1P₁ Receptor and Phe263 of the S1P₃ Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
Mol Pharmacol 2007 71: 724-735. Published online December 14, 2006; 10.1124/mol.106.029223 [Abstract] [Full Text] [PDF]

M. Gomez-Lazaro, M. F. Galindo, R. M. Melero-Fernandez de Mera, F. J. Fernandez-Gómez, C. G. Concannon, M. F. Segura, J. X. Comella, J. H. M. Prehn, and J. Jordan: Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate
Mol Pharmacol 2007 71: 736-743. Published online December 15, 2006; 10.1124/mol.106.030718 [Abstract] [Full Text] [PDF]

M. Cecilia Caino, Jose L. Oliva, Hao Jiang, Trevor M. Penning, and Marcelo G. Kazanietz: Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G₂/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells
Mol Pharmacol 2007 71: 744-750. Published online November 17, 2006; 10.1124/mol.106.032078 [Abstract] [Full Text] [PDF]

Ying Wang, Tip W. Loo, M. Claire Bartlett, and David M. Clarke: Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones
Mol Pharmacol 2007 71: 751-758. Published online November 28, 2006; 10.1124/mol.106.029926 [Abstract] [Full Text] [PDF]

Xi-Ping Huang and John Ellis: Mutational Disruption of a Conserved Disulfide Bond in Muscarinic Acetylcholine Receptors Attenuates Positive Homotropic Cooperativity between Multiple Allosteric Sites and Has Subtype-Dependent Effects on the Affinities of Muscarinic Allosteric Ligands
Mol Pharmacol 2007 71: 759-768. Published online November 28, 2006; 10.1124/mol.106.028944 [Abstract] [Full Text] [PDF]

L. Tapia, A. Kuryatov, and J. Lindstrom: Ca²⁺ Permeability of the ( ${alpha}$ 4)₃( $beta$ 2)₂ Stoichiometry Greatly Exceeds That of ( ${alpha}$ 4)₂( $beta$ 2)₃ Human Acetylcholine Receptors
Mol Pharmacol 2007 71: 769-776. Published online November 28, 2006; 10.1124/mol.106.030445 [Abstract] [Full Text] [PDF]

Hiroshi Tsuneki, Soushi Kobayashi, Kazue Takagi, Syota Kagawa, Masahiko Tsunoda, Masahiko Murata, Tadasu Matsuoka, Tsutomu Wada, Masayoshi Kurachi, Ikuko Kimura, and Toshiyasu Sasaoka: Novel G423S Mutation of Human ${alpha}$ 7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism
Mol Pharmacol 2007 71: 777-786. Published online November 28, 2006; 10.1124/mol.106.030866 [Abstract] [Full Text] [PDF]

Petra Kempná, Gaby Hofer, Primus E. Mullis, and Christa E. Flück: Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2
Mol Pharmacol 2007 71: 787-798. Published online November 30, 2006; 10.1124/mol.106.028902 [Abstract] [Full Text] [PDF]

Friederike Cuello, Andrew K. Snabaitis, Michael S. Cohen, Jack Taunton, and Metin Avkiran: Evidence for Direct Regulation of Myocardial Na⁺/H⁺ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to ${alpha}$ ₁-Adrenergic Stimulation
Mol Pharmacol 2007 71: 799-806. Published online December 1, 2006; 10.1124/mol.106.029900 [Abstract] [Full Text] [PDF]

Guoyu Ling, Yuan Wei, and Xinxin Ding: Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation
Mol Pharmacol 2007 71: 807-816. Published online December 5, 2006; 10.1124/mol.106.031104 [Abstract] [Full Text] [PDF]

Yuji Tanaka, Jonathan M. Maher, Chuan Chen, and Curtis D. Klaassen: Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice
Mol Pharmacol 2007 71: 817-825. Published online December 6, 2006; 10.1124/mol.106.029033 [Abstract] [Full Text] [PDF]

Eric C. K. Siu and Rachel F. Tyndale: Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice
Mol Pharmacol 2007 71: 826-834. Published online December 7, 2006; 10.1124/mol.106.032086 [Abstract] [Full Text] [PDF]

Y. Wei, J. M. Williams, C. Dipace, U. Sung, J. A. Javitch, A. Galli, and C. Saunders: Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca²⁺/Calmodulin-Dependent Kinase II-Dependent Mechanism
Mol Pharmacol 2007 71: 835-842. Published online December 12, 2006; 10.1124/mol.106.026351 [Abstract] [Full Text] [PDF]

Guyllaume Coiret, Anne-Sophie Borowiec, Pascal Mariot, Halima Ouadid-Ahidouch, and Fabrice Matifat: The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells
Mol Pharmacol 2007 71: 843-851. Published online December 12, 2006; 10.1124/mol.106.028290 [Abstract] [Full Text] [PDF]

Anja Zeller, Margarete Arras, Rachel Jurd, and Uwe Rudolph: Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital
Mol Pharmacol 2007 71: 852-859. Published online December 12, 2006; 10.1124/mol.106.030049 [Abstract] [Full Text] [PDF]

Takushi Namba, Tatsuya Hoshino, Ken-ichiro Tanaka, Shinji Tsutsumi, Tomoaki Ishihara, Shinji Mima, Keitarou Suzuki, Satoshi Ogawa, and Tohru Mizushima: Up-Regulation of 150-kDa Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinoma Cells
Mol Pharmacol 2007 71: 860-870. Published online December 13, 2006; 10.1124/mol.106.027698 [Abstract] [Full Text] [PDF]

Brante P. Sampey, David L. Carbone, Jonathan A. Doorn, Derek A. Drechsel, and Dennis R. Petersen: 4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est–Like Protein-1-Activating Protein-1 Signal Transduction
Mol Pharmacol 2007 71: 871-883. Published online December 12, 2006; 10.1124/mol.106.029686 [Abstract] [Full Text] [PDF]

J. A. Shimshoni, E. C. Dalton, A. Jenkins, S. Eyal, K. Ewan, R. S. B. Williams, N. Pessah, B. Yagen, A. J. Harwood, and M. Bialer: The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior
Mol Pharmacol 2007 71: 884-892. Published online December 13, 2006; 10.1124/mol.106.030601 [Abstract] [Full Text] [PDF]

Allison A. Johnson, Christophe Marchand, Sachindra S. Patil, Roberta Costi, Roberto Di Santo, Terrence R. Burke, Jr., and Yves Pommier: Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays
Mol Pharmacol 2007 71: 893-901. Published online December 15, 2006; 10.1124/mol.106.030817 [Abstract] [Full Text] [PDF]

Gaochao Tian, Dee Wilkins, and Clay W. Scott: Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca²⁺ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition
Mol Pharmacol 2007 71: 902-911. Published online December 15, 2006; 10.1124/mol.106.029868 [Abstract] [Full Text] [PDF]

Kazuaki Yoshioka, Naotoshi Sugimoto, Noriko Takuwa, and Yoh Takuwa: Essential Role for Class II Phosphoinositide 3-kinase ${alpha}$ -Isoform in Ca²⁺-Induced, Rho- and Rho Kinase-Dependent Regulation of Myosin Phosphatase and Contraction in Isolated Vascular Smooth Muscle Cells
Mol Pharmacol 2007 71: 912-920. Published online December 19, 2006; 10.1124/mol.106.032599 [Abstract] [Full Text] [PDF] [Data Supplement]

Mohammed I. Al-Salabi, Lynsey J. M. Wallace, Alexandra Lüscher, Pascal Mäser, Denise Candlish, Boris Rodenko, Matthew K. Gould, Ishrat Jabeen, Sreekantan N. Ajith, and Harry P. de Koning: Molecular Interactions Underlying the Unusually High Adenosine Affinity of a Novel Trypanosoma brucei Nucleoside Transporter
Mol Pharmacol 2007 71: 921-929. Published online December 21, 2006; 10.1124/mol.106.031559 [Abstract] [Full Text] [PDF] [Data Supplement]

Mette M. Rosenkilde, Michael B. Andersen, Rie Nygaard, Thomas M. Frimurer, and Thue W. Schwartz: Activation of the CXCR3 Chemokine Receptor through Anchoring of a Small Molecule Chelator Ligand between TM-III, -IV, and -VI
Mol Pharmacol 2007 71: 930-941. Published online December 14, 2006; 10.1124/mol.106.030031 [Abstract] [Full Text] [PDF] [Data Supplement]

Ji-Hong Lim, Jong-Wan Park, Sung Joon Kim, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson, and Yang-Sook Chun: ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1 ${alpha}$ (HIF-1 ${alpha}$ ) Binding and Mediates HIF-1 ${alpha}$ Expression by Bafilomycin A1
Mol Pharmacol 2007 71: 942-948. Published online December 18, 2006; 10.1124/mol.106.030296 [Abstract] [Full Text] [PDF]

Marie Eve Moreau, Marie-Thérèse Bawolak, Guillaume Morissette, Albert Adam, and François Marceau: Role of Nuclear Factor- ${kappa}$ B and Protein Kinase C Signaling in the Expression of the Kinin B₁ Receptor in Human Vascular Smooth Muscle Cells
Mol Pharmacol 2007 71: 949-956. Published online December 18, 2006; 10.1124/mol.106.030684 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Release of cytochrome c, translocation of Bax, and cleavage of α-fodrin in damaged sensory hair cells. See the article by Wang et al. on page 654 of this issue.