Minireview:

Christopher A. Johnston and David P. Siderovski

Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
Mol Pharmacol 2007 72: 219-230. Published online April 12, 2007; 10.1124/mol.107.034348 [Abstract] [Full Text] [PDF]  

Perspectives:

Mariusz W. Szkudlinski

Challenges and Opportunities of Trapping Ligands
Mol Pharmacol 2007 72: 231-234. Published online May 23, 2007; 10.1124/mol.107.038208 [Abstract] [Full Text] [PDF] [Related Article]   

Marie-H. Monfils, Kiriana K. Cowansage, and Joseph E. LeDoux

Brain-Derived Neurotrophic Factor: Linking Fear Learning to Memory Consolidation
Mol Pharmacol 2007 72: 235-237. Published online May 23, 2007; 10.1124/mol.107.038232 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Trudy A. Kohout, Qiu Xie, Shelby Reijmers, Kenneth J. Finn, Zhiqiang Guo, Yun-Fei Zhu, and R. Scott Struthers

Trapping of a Nonpeptide Ligand by the Extracellular Domains of the Gonadotropin-Releasing Hormone Receptor Results in Insurmountable Antagonism
Mol Pharmacol 2007 72: 238-247. Published online April 4, 2007; 10.1124/mol.107.035535 [Abstract] [Full Text] [PDF]  

Yi-He Ling, Tianhong Li, Ziqiang Yuan, Missak Haigentz, Jr., Thomas K. Weber, and Roman Perez-Soler

Erlotinib, an Effective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces p27^KIP1 Up-Regulation and Nuclear Translocation in Association with Cell Growth Inhibition and G₁/S Phase Arrest in Human Non-Small-Cell Lung Cancer Cell Lines
Mol Pharmacol 2007 72: 248-258. Published online April 24, 2007; 10.1124/mol.107.034827 [Abstract] [Full Text] [PDF]  

M. Zhang, X.-S. Liu, S. Diochot, M. Lazdunski, and G.-N. Tseng

APETx1 from Sea Anemone Anthopleura elegantissima Is a Gating Modifier Peptide Toxin of the Human Ether-a-go-go- Related Potassium Channel
Mol Pharmacol 2007 72: 259-268. Published online May 1, 2007; 10.1124/mol.107.035840 [Abstract] [Full Text] [PDF] [Data Supplement]   

Juan Román, Alberto Fernández de Arriba, Sonia Barrón, Pedro Michelena, Marta Giral, Manuel Merlos, Elvira Bailón, Mònica Comalada, Julio Gálvez, Antonio Zarzuelo, and Isabel Ramis

UR-1505, a New Salicylate, Blocks T Cell Activation through Nuclear Factor of Activated T Cells
Mol Pharmacol 2007 72: 269-279. Published online May 2, 2007; 10.1124/mol.107.035212 [Abstract] [Full Text] [PDF]  

Maoqing Dong, Polo C.-H. Lam, Fan Gao, Keiko Hosohata, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan, and Laurence J. Miller

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor
Mol Pharmacol 2007 72: 280-290. Published online May 2, 2007; 10.1124/mol.107.035402 [Abstract] [Full Text] [PDF]  

Tod Steinfeld, Mathai Mammen, Jacqueline A. M. Smith, Richard D. Wilson, and Jeffrey R. Jasper

A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M₂ Muscarinic Receptor
Mol Pharmacol 2007 72: 291-302. Published online May 3, 2007; 10.1124/mol.106.033746 [Abstract] [Full Text] [PDF]  

Joshua G. Jackson, Yuriy M. Usachev, and Stanley A. Thayer

Bradykinin-Induced Nuclear Factor of Activated T-Cells-Dependent Transcription in Rat Dorsal Root Ganglion Neurons
Mol Pharmacol 2007 72: 303-310. Published online May 7, 2007; 10.1124/mol.107.035048 [Abstract] [Full Text] [PDF]  

Amélie Lansiaux, Stéphane Léonce, Laurence Kraus-Berthier, Christine Bal-Mahieu, Romain Mazinghien, Sébastien Didier, Marie-Hélène David-Cordonnier, Patrick Hautefaye, Gilbert Lavielle, Christian Bailly, John A. Hickman, and Alain Pierré

Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
Mol Pharmacol 2007 72: 311-319. Published online May 9, 2007; 10.1124/mol.107.034637 [Abstract] [Full Text] [PDF]  

Mickael J. Cariveau, Xi Tang, Xiao-Li Cui, and Bo Xu

Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity
Mol Pharmacol 2007 72: 320-326. Published online May 16, 2007; 10.1124/mol.107.036681 [Abstract] [Full Text] [PDF] [Data Supplement]   

Pia C. Jensen, Rie Nygaard, Stefanie Thiele, Amy Elder, Guoming Zhu, Roland Kolbeck, Shomir Ghosh, Thue W. Schwartz, and Mette M. Rosenkilde

Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8
Mol Pharmacol 2007 72: 327-340. [Abstract] [Full Text] [PDF] [Erratum]   

Anne Gomez-Brouchet, Dimitri Pchejetski, Leyre Brizuela, Virginie Garcia, Marie-Françoise Altié, Marie-Lise Maddelein, Marie-Bernadette Delisle, and Olivier Cuvillier

Critical Role for Sphingosine Kinase-1 in Regulating Survival of Neuroblastoma Cells Exposed to Amyloid- Peptide
Mol Pharmacol 2007 72: 341-349. Published online May 23, 2007; 10.1124/mol.106.033738 [Abstract] [Full Text] [PDF]  

Li-Chin Ou and Po-Wu Gean

Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory
Mol Pharmacol 2007 72: 350-358. Published online April 24, 2007; 10.1124/mol.107.034934 [Abstract] [Full Text] [PDF]  

Anna N. Bukiya, Jianxi Liu, Ligia Toro, and Alejandro M. Dopico

₁ (KCNMB1) Subunits Mediate Lithocholate Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels and Dilation in Small, Resistance-Size Arteries
Mol Pharmacol 2007 72: 359-369. Published online April 27, 2007; 10.1124/mol.107.034330 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mang Xiao, Cynthia E. Inal, Vaishali I. Parekh, Cheng-Min Chang, and Mark H. Whitnall

5-Androstenediol Promotes Survival of -Irradiated Human Hematopoietic Progenitors through Induction of Nuclear Factor-B Activation and Granulocyte Colony-Stimulating Factor Expression
Mol Pharmacol 2007 72: 370-379. Published online May 1, 2007; 10.1124/mol.107.035394 [Abstract] [Full Text] [PDF]  

Jian-Nong Ma, Hans H. Schiffer, Anne E. Knapp, Jean Wang, Kenneth K. Wong, Erika A. Currier, Michelle Owens, Norman R. Nash, Luis R. Gardell, Mark R. Brann, Roger Olsson, and Ethan S. Burstein

Identification of the Atypical L-Type Ca²⁺ Channel Blocker Diltiazem and Its Metabolites As Ghrelin Receptor Agonists
Mol Pharmacol 2007 72: 380-386. Published online May 2, 2007; 10.1124/mol.107.034298 [Abstract] [Full Text] [PDF]  

Koen van de Wetering, Noam Zelcer, Annemieke Kuil, Wouter Feddema, Michel Hillebrand, Maria L. H. Vlaming, Alfred H. Schinkel, Jos H. Beijnen, and Piet Borst

Multidrug Resistance Proteins 2 and 3 Provide Alternative Routes for Hepatic Excretion of Morphine-Glucuronides
Mol Pharmacol 2007 72: 387-394. Published online May 7, 2007; 10.1124/mol.107.035592 [Abstract] [Full Text] [PDF]  

Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Carolina Simioni, Edward Leung, Stephen Maclennan, Pier Giovanni Baraldi, and Pier Andrea Borea

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells
Mol Pharmacol 2007 72: 395-406. Published online May 8, 2007; 10.1124/mol.106.032920 [Abstract] [Full Text] [PDF]  

José M. Pérez-Ortiz, Pedro Tranque, Miguel Burgos, Cecilia F. Vaquero, and Juan Llopis

Glitazones Induce Astroglioma Cell Death by Releasing Reactive Oxygen Species from Mitochondria: Modulation of Cytotoxicity by Nitric Oxide
Mol Pharmacol 2007 72: 407-417. Published online May 15, 2007; 10.1124/mol.106.032458 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hyung Joon Kim, Youngkyun Lee, Eun-Ju Chang, Hyun-Man Kim, Sam-Pyo Hong, Zang Hee Lee, Jiyoon Ryu, and Hong-Hee Kim

Suppression of Osteoclastogenesis by N,N-Dimethyl-D-erythro-sphingosine: A Sphingosine Kinase Inhibition-Independent Action
Mol Pharmacol 2007 72: 418-428. Published online May 15, 2007; 10.1124/mol.107.034173 [Abstract] [Full Text] [PDF]  

Yongyu Wang, Benjamin Lauffer, Mark Von Zastrow, Brian K. Kobilka, and Yang Xiang

N-Ethylmaleimide-Sensitive Factor Regulates ₂ Adrenoceptor Trafficking and Signaling in Cardiomyocytes
Mol Pharmacol 2007 72: 429-439. Published online May 17, 2007; 10.1124/mol.107.037747 [Abstract] [Full Text] [PDF]  

Wei-Lan Yeh, Dah-Yuu Lu, Chun-Jung Lin, Houng-Chi Liou, and Wen-Mei Fu

Inhibition of Hypoxia-Induced Increase of Blood-Brain Barrier Permeability by YC-1 through the Antagonism of HIF-1 Accumulation and VEGF Expression
Mol Pharmacol 2007 72: 440-449. Published online May 18, 2007; 10.1124/mol.107.036418 [Abstract] [Full Text] [PDF]  

Christopher H. So, Vaneeta Verma, Brian F. O'Dowd, and Susan R. George

Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor
Mol Pharmacol 2007 72: 450-462. Published online May 22, 2007; 10.1124/mol.107.034884 [Abstract] [Full Text] [PDF]  

Lauren T. May, Vimesh A. Avlani, Christopher J. Langmead, Hugh J. Herdon, Martyn D. Wood, Patrick M. Sexton, and Arthur Christopoulos

Structure-Function Studies of Allosteric Agonism at M₂ Muscarinic Acetylcholine Receptors
Mol Pharmacol 2007 72: 463-476. Published online May 24, 2007; 10.1124/mol.107.037630 [Abstract] [Full Text] [PDF]  

Michael A. Benneyworth, Zixiu Xiang, Randy L. Smith, Efrain E. Garcia, P. Jeffrey Conn, and Elaine Sanders-Bush

A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis
Mol Pharmacol 2007 72: 477-484. Published online May 25, 2007; 10.1124/mol.107.035170 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Structure of the d(CGCGAATTCGCG)₂ Complex of the Minor Groove Binding Alkylating Agent Alkamin Studied by Mass Spectrometry"
Mol Pharmacol 2007 72: 485. [Full Text] [PDF]  

Correction to "Development of a Novel Nitro-Derivative of Noscapine for the Potential Treatment of Drug-Resistant Ovarian Cancer and T-Cell Lymphoma"
Mol Pharmacol 2007 72: 486. [Full Text] [PDF]  

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