Minireview:

Brian J. McMillan and Christopher A. Bradfield

The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
Mol Pharmacol 2007 72: 487-498. Published online May 29, 2007; 10.1124/mol.107.037259 [Abstract] [Full Text] [PDF]  

Perspective:

Eun Choi and Geoffrey W. Abbott

The MiRP2-Kv3.4 Potassium Channel: Muscling In on Alzheimer's Disease
Mol Pharmacol 2007 72: 499-501. Published online June 26, 2007; 10.1124/mol.107.039206 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Ute Renner, Konstantin Glebov, Thorsten Lang, Ekaterina Papusheva, Saju Balakrishnan, Bernhard Keller, Diethelm W. Richter, Reinhard Jahn, and Evgeni Ponimaskin

Localization of the Mouse 5-Hydroxytryptamine_1A Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling
Mol Pharmacol 2007 72: 502-513. Published online May 31, 2007; 10.1124/mol.107.037085 [Abstract] [Full Text] [PDF]  

Jason S. Biggs, Jie Wan, N. Shane Cutler, Jukka Hakkola, Päivi Uusimäki, Hannu Raunio, and Garold S. Yost

Transcription Factor Binding to a Putative Double E-Box Motif Represses CYP3A4 Expression in Human Lung Cells
Mol Pharmacol 2007 72: 514-525. Published online June 4, 2007; 10.1124/mol.106.033795 [Abstract] [Full Text] [PDF]  

Martin Göttle, Stefan Dove, Phillip Steindel, Yuequan Shen, Wei-Jen Tang, Jens Geduhn, Burkhard König, and Roland Seifert

Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides
Mol Pharmacol 2007 72: 526-535. Published online June 6, 2007; 10.1124/mol.107.034413 [Abstract] [Full Text] [PDF]  

Wing Lam, Chung-Hang Leung, Scott Bussom, and Yung-Chi Cheng

The Impact of Hypoxic Treatment on the Expression of Phosphoglycerate Kinase and the Cytotoxicity of Troxacitabine and Gemcitabine
Mol Pharmacol 2007 72: 536-544. Published online June 12, 2007; 10.1124/mol.106.033472 [Abstract] [Full Text] [PDF] [Data Supplement]   

Fang Tian, Cai-hua Zhu, Xiong-wen Zhang, Xin Xie, Xian-liang Xin, Yang-hua Yi, Li-ping Lin, Mei-yu Geng, and Jian Ding

Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction between Kinase Insert Domain-Containing Receptor (KDR) and _v3 Integrin via Binding to the Extracellular Domain of KDR
Mol Pharmacol 2007 72: 545-552. Published online June 12, 2007; 10.1124/mol.107.036350 [Abstract] [Full Text] [PDF]  

Amy B. Foraker, Abhijit Ray, Tatiana Claro Da Silva, Lisa M. Bareford, Kathleen M. Hillgren, Thomas D. Schmittgen, and Peter W. Swaan

Dynamin 2 Regulates Riboflavin Endocytosis in Human Placental Trophoblasts
Mol Pharmacol 2007 72: 553-562. Published online June 12, 2007; 10.1124/mol.107.037101 [Abstract] [Full Text] [PDF]  

Jessica Huyet, Grégory M. Pinon, Michel R. Fay, Jérôme Fagart, and Marie-Edith Rafestin-Oblin

Structural Basis of Spirolactone Recognition by the Mineralocorticoid Receptor
Mol Pharmacol 2007 72: 563-571. Published online June 14, 2007; 10.1124/mol.107.036459 [Abstract] [Full Text] [PDF]  

Géraldine Lemaire, Cindy Benod, Virginie Nahoum, Arnaud Pillon, Anne-Marie Boussioux, Jean-François Guichou, Guy Subra, Jean-Marc Pascussi, William Bourguet, Alain Chavanieu, and Patrick Balaguer

Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to "In Vivo" Biological Activity
Mol Pharmacol 2007 72: 572-581. Published online June 15, 2007; 10.1124/mol.106.033415 [Abstract] [Full Text] [PDF] [Data Supplement]   

Leif Erik Vinge, Kjetil W. Andressen, Toril Attramadal, Geir Øystein Andersen, Mohammed Shakil Ahmed, Karsten Peppel, Walter J. Koch, Neil J. Freedman, Finn Olav Levy, Tor Skomedal, Jan-Bjørn Osnes, and Håvard Attramadal

Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function
Mol Pharmacol 2007 72: 582-591. Published online June 15, 2007; 10.1124/mol.107.035766 [Abstract] [Full Text] [PDF]  

Sean Ekins, Cheng Chang, Sridhar Mani, Matthew D. Krasowski, Erica J. Reschly, Manisha Iyer, Vladyslav Kholodovych, Ni Ai, William J. Welsh, Michael Sinz, Peter W. Swaan, Rachana Patel, and Kenneth Bachmann

Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites
Mol Pharmacol 2007 72: 592-603. Published online June 18, 2007; 10.1124/mol.107.038398 [Abstract] [Full Text] [PDF] [Data Supplement]   

Anne-Sisko Patana, Mika Kurkela, Adrian Goldman, and Moshe Finel

The Human UDP-Glucuronosyltransferase: Identification of Key Residues within the Nucleotide-Sugar Binding Site
Mol Pharmacol 2007 72: 604-611. Published online June 19, 2007; 10.1124/mol.107.036871 [Abstract] [Full Text] [PDF]  

Kwang-Mook Jung, Giuseppe Astarita, Chenggang Zhu, Matthew Wallace, Ken Mackie, and Daniele Piomelli

A Key Role for Diacylglycerol Lipase- in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization
Mol Pharmacol 2007 72: 612-621. Published online June 21, 2007; 10.1124/mol.107.037796 [Abstract] [Full Text] [PDF]  

Eun Young Kim, Lon D. Ridgway, and Stuart E. Dryer

Interactions with Filamin A Stimulate Surface Expression of Large-Conductance Ca²⁺-Activated K⁺ Channels in the Absence of Direct Actin Binding
Mol Pharmacol 2007 72: 622-630. Published online June 22, 2007; 10.1124/mol.107.038026 [Abstract] [Full Text] [PDF]  

Bertrand Brassart, Dennis Gomez, Anne De Cian, Rajaa Paterski, Alain Montagnac, Khuong-Huu Qui, Nassima Temime-Smaali, Chantal Trentesaux, Jean-Louis Mergny, Françoise Gueritte, and Jean-François Riou

A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells
Mol Pharmacol 2007 72: 631-640. Published online June 22, 2007; 10.1124/mol.107.036574 [Abstract] [Full Text] [PDF]  

K. To, Y. Zhao, H. Jiang, K. Hu, M. Wang, J. Wu, C. Lee, D. W. Yokom, A. L. Stratford, U. Klinge, P. R. Mertens, C. S. Chen, M. Bally, D. Yapp, and S. E. Dunn

The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor
Mol Pharmacol 2007 72: 641-652. Published online June 26, 2007; 10.1124/mol.107.036111 [Abstract] [Full Text] [PDF]  

Cecily E. Hamill, W. Michael Caudle, Jason R. Richardson, Hongjie Yuan, Kurt D. Pennell, James G. Greene, Gary W. Miller, and Stephen F. Traynelis

Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson's Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1
Mol Pharmacol 2007 72: 653-664. Published online June 27, 2007; 10.1124/mol.107.038158 [Abstract] [Full Text] [PDF] [Data Supplement]   

A. Pannaccione, F. Boscia, A. Scorziello, A. Adornetto, P. Castaldo, R. Sirabella, M. Taglialatela, G. F. Di Renzo, and L. Annunziato

Up-Regulation and Increased Activity of K_V3.4 Channels and Their Accessory Subunit MinK-Related Peptide 2 Induced by Amyloid Peptide Are Involved in Apoptotic Neuronal Death
Mol Pharmacol 2007 72: 665-673. Published online May 10, 2007; 10.1124/mol.107.034868 [Abstract] [Full Text] [PDF]  

Ki Young Kim, Jin Hee Ahn, and Hyae Gyeong Cheon

Apoptotic Action of Peroxisome Proliferator-Activated Receptor- Activation in Human Non–Small-Cell Lung Cancer Is Mediated via Proline Oxidase-Induced Reactive Oxygen Species Formation
Mol Pharmacol 2007 72: 674-685. Published online May 29, 2007; 10.1124/mol.107.035584 [Abstract] [Full Text] [PDF]  

Jian Yang, Deshi Shi, Dongfang Yang, Xiulong Song, and Bingfang Yan

Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Oseltamivir by Suppressing the Expression of Carboxylesterases HCE1 and HCE2
Mol Pharmacol 2007 72: 686-694. Published online May 30, 2007; 10.1124/mol.107.036889 [Abstract] [Full Text] [PDF]  

Yung-Cheng Chiu, Rong-Sen Yang, Kuo-Hsien Hsieh, Yi-Chin Fong, Tzong-Der Way, Tu-Sheng Lee, Hsi-Chin Wu, Wen-Mei Fu, and Chih-Hsin Tang

Stromal Cell-Derived Factor-1 Induces Matrix Metalloprotease-13 Expression in Human Chondrocytes
Mol Pharmacol 2007 72: 695-703. Published online June 5, 2007; 10.1124/mol.107.036541 [Abstract] [Full Text] [PDF]  

Clint Mitchell, Peyman Kabolizadeh, John Ryan, John D. Roberts, Adly Yacoub, David T. Curiel, Paul B. Fisher, Michael P. Hagan, Nicholas P. Farrell, Steven Grant, and Paul Dent

Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling
Mol Pharmacol 2007 72: 704-714. Published online June 19, 2007; 10.1124/mol.107.038406 [Abstract] [Full Text] [PDF]  

Jens Halvard Grønlien, Monika Håkerud, Hilde Ween, Kirsten Thorin-Hagene, Clark A. Briggs, Murali Gopalakrishnan, and John Malysz

Distinct Profiles of 7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Mol Pharmacol 2007 72: 715-724. Published online June 12, 2007; 10.1124/mol.107.035410 [Abstract] [Full Text] [PDF]  

Shuo Wei, Li-Fang Lin, Chih-Cheng Yang, Yu-Chieh Wang, Geen-Dong Chang, Hungwen Chen, and Ching-Shih Chen

Thiazolidinediones Modulate the Expression of -Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of Skp1-Cul1-F-box Protein E3 Ubiquitin Ligase Independently of Peroxisome Proliferator-Activated Receptor
Mol Pharmacol 2007 72: 725-733. Published online June 14, 2007; 10.1124/mol.107.035287 [Abstract] [Full Text] [PDF]  

Sukhwinder S. Lakhman, Xiaomin Chen, Vanessa Gonzalez-Covarrubias, Erin G. Schuetz, and Javier G. Blanco

Functional Characterization of the Promoter of Human Carbonyl Reductase 1 (CBR1). Role of XRE Elements in Mediating the Induction of CBR1 by Ligands of the Aryl Hydrocarbon Receptor
Mol Pharmacol 2007 72: 734-743. Published online June 14, 2007; 10.1124/mol.107.035550 [Abstract] [Full Text] [PDF]  

Warren C. Samms, Rohan P. Perera, D. S. Wimalasena, and K. Wimalasena

Perturbation of Dopamine Metabolism by 3-Amino-2-(4'-halophenyl)propenes Leads to Increased Oxidative Stress and Apoptotic SH-SY5Y Cell Death
Mol Pharmacol 2007 72: 744-752. Published online June 18, 2007; 10.1124/mol.107.035873 [Abstract] [Full Text] [PDF]  

Sumita Chakrabarti and Alan R. Gintzler

Phosphorylation of G_s Influences Its Association with the µ-Opioid Receptor and Is Modulated by Long-Term Morphine Exposure
Mol Pharmacol 2007 72: 753-760. Published online June 18, 2007; 10.1124/mol.107.036145 [Abstract] [Full Text] [PDF]  

Sanna Kaivosaari, Päivi Toivonen, Leah M. Hesse, Mikko Koskinen, Michael H. Court, and Moshe Finel

Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10
Mol Pharmacol 2007 72: 761-768. Published online June 18, 2007; 10.1124/mol.107.037093 [Abstract] [Full Text] [PDF]  

Jill M. Siegfried, Christopher T. Gubish, Mary E. Rothstein, Pierre E. Queiroz de Oliveira, and Laura P. Stabile

Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non–Small-Cell Lung Cancer
Mol Pharmacol 2007 72: 769-779. Published online June 5, 2007; 10.1124/mol.107.034215 [Abstract] [Full Text] [PDF] [Data Supplement]   

Christian Grasshoff, Rachel Jurd, Uwe Rudolph, and Bernd Antkowiak

Modulation of Presynaptic 3-Containing GABA_A Receptors Limits the Immobilizing Actions of GABAergic Anesthetics
Mol Pharmacol 2007 72: 780-787. Published online June 21, 2007; 10.1124/mol.107.037648 [Abstract] [Full Text] [PDF]  

Mohamed Rahmani, Tri K. Nguyen, Paul Dent, and Steven Grant

The Multikinase Inhibitor Sorafenib Induces Apoptosis in Highly Imatinib Mesylate-Resistant Bcr/Abl⁺ Human Leukemia Cells in Association with Signal Transducer and Activator of Transcription 5 Inhibition and Myeloid Cell Leukemia-1 Down-Regulation
Mol Pharmacol 2007 72: 788-795. Published online June 26, 2007; 10.1124/mol.106.033308 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Chromanol 293B Binding in KCNQ1 (Kv7.1) Channels Involves Electrostatic Interactions with a Potassium Ion in the Selectivity Filter"
Mol Pharmacol 2007 72: 796. [Full Text] [PDF]  

Correction to "Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with µ Conotoxin Binding Sites"
Mol Pharmacol 2007 72: 797. [Full Text] [PDF]  

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