Minireview:

Robert Newton and Neil S. Holden

Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?
Mol Pharmacol 2007 72: 799-809. Published online July 10, 2007; 10.1124/mol.107.038794 [Abstract] [Full Text] [PDF]  

Perspective:

Corinne E. Zeller and Henrik G. Dohlman

Illuminating G₅ Signaling
Mol Pharmacol 2007 72: 810-811. Published online July 16, 2007; 10.1124/mol.107.040055 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Evan A. Yost, Stacy M. Mervine, Jonathan L. Sabo, Thomas R. Hynes, and Catherine H. Berlot

Live Cell Analysis of G Protein ₅ Complex Formation, Function, and Targeting
Mol Pharmacol 2007 72: 812-825. Published online June 27, 2007; 10.1124/mol.107.038075 [Abstract] [Full Text] [PDF]  

Kazuhiro Kosuge, Andrew I. Chuang, Satoko Uematsu, Kah Poh Tan, Kyoichi Ohashi, Ben C.B. Ko, and Shinya Ito

Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Activated T Cells 5)
Mol Pharmacol 2007 72: 826-837. Published online June 28, 2007; 10.1124/mol.107.034504 [Abstract] [Full Text] [PDF]  

Elaine A. Gay, Rachelle J. Bienstock, Patricia W. Lamb, and Jerrel L. Yakel

Structural Determinates for Apolipoprotein E-Derived Peptide Interaction with the 7 Nicotinic Acetylcholine Receptor
Mol Pharmacol 2007 72: 838-849. Published online July 3, 2007; 10.1124/mol.107.035527 [Abstract] [Full Text] [PDF] [Data Supplement]   

Chihiro Tamaki, Sumio Ohtsuki, and Tetsuya Terasaki

Insulin Facilitates the Hepatic Clearance of Plasma Amyloid -Peptide (1–40) by Intracellular Translocation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP-1) to the Plasma Membrane in Hepatocytes
Mol Pharmacol 2007 72: 850-855. Published online July 3, 2007; 10.1124/mol.107.036913 [Abstract] [Full Text] [PDF]  

Sandeep C. Pingle, Sarvesh Jajoo, Debashree Mukherjea, Lynn F. Sniderhan, Krishna A. Jhaveri, Adriana Marcuzzi, Leonard P. Rybak, Sanjay B. Maggirwar, and Vickram Ramkumar

Activation of the Adenosine A₁ Receptor Inhibits HIV-1 Tat-Induced Apoptosis by Reducing Nuclear Factor-B Activation and Inducible Nitric-Oxide Synthase
Mol Pharmacol 2007 72: 856-867. Published online July 3, 2007; 10.1124/mol.106.031427 [Abstract] [Full Text] [PDF]  

Hyun-Ku Lee, Steven J. Brown, Hugh Rosen, and Peter S. Tobias

Application of -Lactamase Enzyme Complementation to the High-Throughput Screening of Toll-Like Receptor Signaling Inhibitors
Mol Pharmacol 2007 72: 868-875. Published online July 5, 2007; 10.1124/mol.107.038349 [Abstract] [Full Text] [PDF] [Data Supplement]   

Andrew G. Jobson, John H. Cardellina, II, Dominic Scudiero, Sudhir Kondapaka, Hongliang Zhang, Hijoo Kim, Robert Shoemaker, and Yves Pommier

Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase
Mol Pharmacol 2007 72: 876-884. Published online July 6, 2007; 10.1124/mol.107.035832 [Abstract] [Full Text] [PDF]  

Jian Qiu, Changhui Xue, Martha A. Bosch, Jonathan G. Murphy, Wei Fan, Oline K. Rønnekleiv, and Martin J. Kelly

Serotonin 5-Hydroxytryptamine_2C Receptor Signaling in Hypothalamic Proopiomelanocortin Neurons: Role in Energy Homeostasis in Females
Mol Pharmacol 2007 72: 885-896. Published online July 10, 2007; 10.1124/mol.107.038083 [Abstract] [Full Text] [PDF]  

Stephen J. Gardell, Julie A. Krueger, Thomas A. Antrilli, Hassan Elokdah, Scott Mayer, Steven J. Orcutt, David L. Crandall, and George P. Vlasuk

Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action
Mol Pharmacol 2007 72: 897-906. Published online July 10, 2007; 10.1124/mol.107.037010 [Abstract] [Full Text] [PDF]  

Kevin Erreger, Matthew T. Geballe, Anders Kristensen, Philip E. Chen, Kasper B. Hansen, C. Justin Lee, Hongjie Yuan, Phuong Le, Polina N. Lyuboslavsky, Nicola Micale, Lars Jørgensen, Rasmus P. Clausen, David J. A. Wyllie, James P. Snyder, and Stephen F. Traynelis

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-D-aspartate Glutamate Receptors
Mol Pharmacol 2007 72: 907-920. Published online July 10, 2007; 10.1124/mol.107.037333 [Abstract] [Full Text] [PDF]  

Arindam Pal, Abdol R. Hajipour, Dominique Fontanilla, Subramaniam Ramachandran, Uyen B. Chu, Timur Mavlyutov, and Arnold E. Ruoho

Identification of Regions of the -1 Receptor Ligand Binding Site Using a Novel Photoprobe
Mol Pharmacol 2007 72: 921-933. Published online July 10, 2007; 10.1124/mol.107.038307 [Abstract] [Full Text] [PDF]  

Subhajit Dasgupta, Avik Roy, Malabendu Jana, Dean M. Hartley, and Kalipada Pahan

Gemfibrozil Ameliorates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Independent of Peroxisome Proliferator-Activated Receptor-
Mol Pharmacol 2007 72: 934-946. Published online July 11, 2007; 10.1124/mol.106.033787 [Abstract] [Full Text] [PDF]  

Pia Kotokorpi, Ewa Ellis, Paolo Parini, Lisa-Mari Nilsson, Stephen Strom, Knut R. Steffensen, Jan-Åke Gustafsson, and Agneta Mode

Physiological Differences between Human and Rat Primary Hepatocytes in Response to Liver X Receptor Activation by 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic Acid Hydrochloride (GW3965)
Mol Pharmacol 2007 72: 947-955. Published online July 12, 2007; 10.1124/mol.107.037358 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ivy D. Moffat, Steven Roblin, Patricia A. Harper, Allan B. Okey, and Raimo Pohjanvirta

Aryl Hydrocarbon Receptor Splice Variants in the Dioxin-Resistant Rat: Tissue Expression and Transactivational Activity
Mol Pharmacol 2007 72: 956-966. Published online July 17, 2007; 10.1124/mol.107.037218 [Abstract] [Full Text] [PDF] [Data Supplement]   

Junichi Enokizono, Hiroyuki Kusuhara, and Yuichi Sugiyama

Effect of Breast Cancer Resistance Protein (Bcrp/Abcg2) on the Disposition of Phytoestrogens
Mol Pharmacol 2007 72: 967-975. Published online July 20, 2007; 10.1124/mol.107.034751 [Abstract] [Full Text] [PDF]  

Caihong Zhou, Song Zhang, Masakatsu Nanamori, Yueyun Zhang, Qing Liu, Na Li, Meiling Sun, Jun Tian, Patrick P. Ye, Ni Cheng, Richard D. Ye, and Ming-Wei Wang

Pharmacological Characterization of a Novel Nonpeptide Antagonist for Formyl Peptide Receptor-Like 1
Mol Pharmacol 2007 72: 976-983. Published online July 25, 2007; 10.1124/mol.107.037564 [Abstract] [Full Text] [PDF] [Data Supplement] [Erratum]   

Chun-Chieh Hsu, Wen-Bin Wu, Ya-Hui Chang, Heng-Lan Kuo, and Tur-Fu Huang

Antithrombotic Effect of a Protein-Type I Class Snake Venom Metalloproteinase, Kistomin, Is Mediated by Affecting Glycoprotein Ib-von Willebrand Factor Interaction
Mol Pharmacol 2007 72: 984-992. Published online July 3, 2007; 10.1124/mol.107.038018 [Abstract] [Full Text] [PDF]  

Elda Grabocka and Philip B. Wedegaertner

Disruption of Oligomerization Induces Nucleocytoplasmic Shuttling of Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor
Mol Pharmacol 2007 72: 993-1002. Published online July 3, 2007; 10.1124/mol.107.035162 [Abstract] [Full Text] [PDF] [Data Supplement]   

Morten Grauslund, Annemette Vinding Thougaard, Annette Füchtbauer, Kenneth Francis Hofland, Peter Hansen Hjorth, Peter B. Jensen, Maxwell Sehested, Ernst-Martin Füchtbauer, and Lars H. Jensen

A Mouse Model for Studying the Interaction of Bisdioxopiperazines with Topoisomerase II in Vivo
Mol Pharmacol 2007 72: 1003-1014. Published online July 10, 2007; 10.1124/mol.107.036970 [Abstract] [Full Text] [PDF]  

Barbara Benassi, Gabriella Zupi, and Annamaria Biroccio

-Glutamylcysteine Synthetase Mediates the c-Myc-Dependent Response to Antineoplastic Agents in Melanoma Cells
Mol Pharmacol 2007 72: 1015-1023. Published online July 12, 2007; 10.1124/mol.107.038687 [Abstract] [Full Text] [PDF] [Data Supplement]   

Charles E. Spivak, Carl R. Lupica, and Murat Oz

The Endocannabinoid Anandamide Inhibits the Function of 42 Nicotinic Acetylcholine Receptors
Mol Pharmacol 2007 72: 1024-1032. Published online July 12, 2007; 10.1124/mol.107.036939 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bo Hjorth Bentzen, Antonio Nardi, Kirstine Calloe, Lars Siim Madsen, Søren-Peter Olesen, and Morten Grunnet

The Small Molecule NS11021 Is a Potent and Specific Activator of Ca²⁺-Activated Big-Conductance K⁺ Channels
Mol Pharmacol 2007 72: 1033-1044. Published online July 16, 2007; 10.1124/mol.107.038331 [Abstract] [Full Text] [PDF]  

Hisashi Masuyama, Hideki Nakatsukasa, Norio Takamoto, and Yuji Hiramatsu

Down-Regulation of Pregnane X Receptor Contributes to Cell Growth Inhibition and Apoptosis by Anticancer Agents in Endometrial Cancer Cells
Mol Pharmacol 2007 72: 1045-1053. Published online July 17, 2007; 10.1124/mol.107.037937 [Abstract] [Full Text] [PDF]  

Takahiro Kubota, Benjamin C. Lewis, David J. Elliot, Peter I. Mackenzie, and John O. Miners

Critical Roles of Residues 36 and 40 in the Phenol and Tertiary Amine Aglycone Substrate Selectivities of UDP-Glucuronosyltransferases 1A3 and 1A4
Mol Pharmacol 2007 72: 1054-1062. Published online July 17, 2007; 10.1124/mol.107.037952 [Abstract] [Full Text] [PDF]  

Qingen Ke, Yong-Fu Xiao, J. Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, John M. Seubert, and Darryl C. Zeldin

Electrophysiological Properties of Cardiomyocytes Isolated from CYP2J2 Transgenic Mice
Mol Pharmacol 2007 72: 1063-1073. Published online July 24, 2007; 10.1124/mol.107.035881 [Abstract] [Full Text] [PDF]  

Sally E. Purdom-Dickinson, Elena V. Sheveleva, Haipeng Sun, and Qin M. Chen

Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants
Mol Pharmacol 2007 72: 1074-1081. Published online July 25, 2007; 10.1124/mol.107.035360 [Abstract] [Full Text] [PDF]  

Jeong Yong Lee, Chang Yeob Han, Jin Won Yang, Christopher Smith, Sang Kyum Kim, Eva Y.-H. P. Lee, Sang Geon Kim, and Keon Wook Kang

Induction of Glutathione Transferase in Insulin-Like Growth Factor Type I Receptor-Overexpressed Hepatoma Cells
Mol Pharmacol 2007 72: 1082-1093. Published online July 5, 2007; 10.1124/mol.107.038174 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug"
Mol Pharmacol 2007 72: 1094. [Full Text] [PDF]  

Correction to "Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8"
Mol Pharmacol 2007 72: 1095. [Full Text] [PDF]  

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