Perspectives:

Martin C. Michel and Astrid E. Alewijnse

Ligand-Directed Signaling: 50 Ways to Find a Lover
Mol Pharmacol 2007 72: 1097-1099. Published online August 23, 2007; 10.1124/mol.107.040923 [Abstract] [Full Text] [PDF] [Related Article]   

Delany Torres-Salazar and Christoph Fahlke

Parawixin1: A Spider Toxin Opening New Avenues for Glutamate Transporter Pharmacology
Mol Pharmacol 2007 72: 1100-1102. Published online August 28, 2007; 10.1124/mol.107.041020 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Masahiko Watabe, Koji Aoyama, and Toshio Nakaki

Regulation of Glutathione Synthesis via Interaction between Glutamate Transport-Associated Protein 3-18 (GTRAP3-18) and Excitatory Amino Acid Carrier-1 (EAAC1) at Plasma Membrane
Mol Pharmacol 2007 72: 1103-1110. Published online July 23, 2007; 10.1124/mol.107.039461 [Abstract] [Full Text] [PDF]  

Antonello Mai, Katija Jelicic, Dante Rotili, Antonella Di Noia, Elena Alfani, Sergio Valente, Lucia Altucci, Angela Nebbioso, Silvio Massa, Renzo Galanello, Gerald Brosch, Anna Rita Migliaccio, and Giovanni Migliaccio

Identification of Two New Synthetic Histone Deacetylase Inhibitors That Modulate Globin Gene Expression in Erythroid Cells from Healthy Donors and Patients with Thalassemia
Mol Pharmacol 2007 72: 1111-1123. Published online July 31, 2007; 10.1124/mol.107.036772 [Abstract] [Full Text] [PDF] [Data Supplement]   

Leonardo M. Porchia, Marcy Guerra, Yu-Chieh Wang, Yunlong Zhang, Allan V. Espinosa, Motoo Shinohara, Samuel K. Kulp, Lawrence S. Kirschner, Motoyasu Saji, Ching-Shih Chen, and Matthew D. Ringel

2-Amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase
Mol Pharmacol 2007 72: 1124-1131. Published online August 2, 2007; 10.1124/mol.107.037556 [Abstract] [Full Text] [PDF]  

L. S. Harrington, R. J. Evans, J. Wray, L. Norling, K. E. Swales, C. Vial, F. Ali, M. J. Carrier, and J. A. Mitchell

Purinergic 2X₁ Receptors Mediate Endothelial Dependent Vasodilation to ATP
Mol Pharmacol 2007 72: 1132-1136. Published online August 3, 2007; 10.1124/mol.107.037325 [Abstract] [Full Text] [PDF]  

Zhenfeng Duan, James Bradner, Edward Greenberg, Ralph Mazitschek, Rosemary Foster, Jennifer Mahoney, and Michael V. Seiden

8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells
Mol Pharmacol 2007 72: 1137-1145. Published online August 3, 2007; 10.1124/mol.107.038117 [Abstract] [Full Text] [PDF]  

Brian J. Dewar, Olivia S. Gardner, Ching-Shih Chen, H. Shelton Earp, James M. Samet, and Lee M. Graves

Capacitative Calcium Entry Contributes to the Differential Transactivation of the Epidermal Growth Factor Receptor in Response to Thiazolidinediones
Mol Pharmacol 2007 72: 1146-1156. Published online August 8, 2007; 10.1124/mol.107.037549 [Abstract] [Full Text] [PDF]  

Michael M. C. Kong, Ahmed Hasbi, Michael Mattocks, Theresa Fan, Brian F. O'Dowd, and Susan R. George

Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1
Mol Pharmacol 2007 72: 1157-1170. Published online August 15, 2007; 10.1124/mol.107.034769 [Abstract] [Full Text] [PDF]  

Noriyuki Nakatsu, Tomoki Nakamura, Kanami Yamazaki, Soutaro Sadahiro, Hiroyasu Makuuchi, Jun Kanno, and Takao Yamori

Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39, a Panel of Human Cancer Cell Lines
Mol Pharmacol 2007 72: 1171-1180. Published online August 16, 2007; 10.1124/mol.107.038836 [Abstract] [Full Text] [PDF] [Data Supplement]   

Christiane Rothkegel, Peter M. Schmidt, Derek-John Atkins, Linda Sarah Hoffmann, Harald H. H. W. Schmidt, Henning Schröder, and Johannes-Peter Stasch

Dimerization Region of Soluble Guanylate Cyclase Characterized by Bimolecular Fluorescence Complementation in Vivo
Mol Pharmacol 2007 72: 1181-1190. Published online August 22, 2007; 10.1124/mol.107.036368 [Abstract] [Full Text] [PDF] [Data Supplement]   

Santosh Kumar, Yonghong Zhao, Ling Sun, Surendra S. Negi, James R. Halpert, and B. K. Muralidhara

Rational Engineering of Human Cytochrome P450 2B6 for Enhanced Expression and Stability: Importance of a Leu²⁶⁴Phe Substitution
Mol Pharmacol 2007 72: 1191-1199. Published online August 22, 2007; 10.1124/mol.107.039693 [Abstract] [Full Text] [PDF] [Data Supplement]   

Michael R. Braden and David E. Nichols

Assessment of the Roles of Serines 5.43(239) and 5.46(242) for Binding and Potency of Agonist Ligands at the Human Serotonin 5-HT_2A Receptor
Mol Pharmacol 2007 72: 1200-1209. Published online August 22, 2007; 10.1124/mol.107.039255 [Abstract] [Full Text] [PDF]  

Eun-Ja Yoon, Tatyana Gerachshenko, Bryan D. Spiegelberg, Simon Alford, and Heidi E. Hamm

G Interferes with Ca²⁺-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex
Mol Pharmacol 2007 72: 1210-1219. Published online August 22, 2007; 10.1124/mol.107.039446 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lior Cohen, Yael Troub, Michael Turkov, Nicolas Gilles, Nitza Ilan, Morris Benveniste, Dalia Gordon, and Michael Gurevitz

Mammalian Skeletal Muscle Voltage-Gated Sodium Channels Are Affected by Scorpion Depressant "Insect-Selective" Toxins when Preconditioned
Mol Pharmacol 2007 72: 1220-1227. Published online August 24, 2007; 10.1124/mol.107.039057 [Abstract] [Full Text] [PDF]  

Andréia Cristina Karklin Fontana, Renê de Oliveira Beleboni, Marcin Wlodzimierz Wojewodzic, Wagner Ferreira dos Santos, Joaquim Coutinho-Netto, Nina Julie Grutle, Spencer D. Watts, Niels Christian Danbolt, and Susan G. Amara

Enhancing Glutamate Transport: Mechanism of Action of Parawixin1, a Neuroprotective Compound from Parawixia bistriata Spider Venom
Mol Pharmacol 2007 72: 1228-1237. Published online July 23, 2007; 10.1124/mol.107.037127 [Abstract] [Full Text] [PDF]  

Heng Lin, Chun-Cheng Hou, Ching-Feng Cheng, Ted-H. Chiu, Yung-Ho Hsu, Yuh-Mou Sue, Tso-Hsiao Chen, Hsin-Han Hou, Ying-Chi Chao, Tzu-Hurng Cheng, and Cheng-Hsien Chen

Peroxisomal Proliferator-Activated Receptor- Protects Renal Tubular Cells from Doxorubicin-Induced Apoptosis
Mol Pharmacol 2007 72: 1238-1245. Published online August 1, 2007; 10.1124/mol.107.037523 [Abstract] [Full Text] [PDF]  

Cinzia Fionda, Filomena Nappi, Mario Piccoli, Luigi Frati, Angela Santoni, and Marco Cippitelli

Inhibition of Trail Gene Expression by Cyclopentenonic Prostaglandin 15-Deoxy-^12,14-Prostaglandin J₂ in T Lymphocytes
Mol Pharmacol 2007 72: 1246-1257. Published online August 2, 2007; 10.1124/mol.107.038042 [Abstract] [Full Text] [PDF]  

Véronique Juvin, Aubin Penna, Jean Chemin, Yea-Lih Lin, and François-A. Rassendren

Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate
Mol Pharmacol 2007 72: 1258-1268. Published online August 2, 2007; 10.1124/mol.107.037044 [Abstract] [Full Text] [PDF] [Data Supplement]   

Shuzhen Chen, Xiangguo Liu, Ping Yue, Axel H. Schönthal, Fadlo R. Khuri, and Shi-Yong Sun

CCAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction and Ubiquitin/Proteasome-Mediated Cellular FLICE-Inhibitory Protein Down-Regulation Contribute to Enhancement of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Dimethyl-Celecoxib in Human Non–Small-Cell Lung Cancer Cells
Mol Pharmacol 2007 72: 1269-1279. Published online August 7, 2007; 10.1124/mol.107.037465 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lian Wei, Charles W. Locuson, and Timothy S. Tracy

Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity
Mol Pharmacol 2007 72: 1280-1288. Published online August 8, 2007; 10.1124/mol.107.036178 [Abstract] [Full Text] [PDF]  

Fang He, Zhuan-Hong Qiao, Jian Cai, William Pierce, Da-Cheng He, and Zhao-Hui Song

Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G Protein-Coupled Receptor
Mol Pharmacol 2007 72: 1289-1300. Published online August 14, 2007; 10.1124/mol.107.036566 [Abstract] [Full Text] [PDF]  

Laura Moreno, Giovanna Frazziano, Angel Cogolludo, Laura Cobeño, Juan Tamargo, and Francisco Perez-Vizcaino

Role of Protein Kinase C and Its Adaptor Protein p62 in Voltage-Gated Potassium Channel Modulation in Pulmonary Arteries
Mol Pharmacol 2007 72: 1301-1309. Published online August 15, 2007; 10.1124/mol.107.037002 [Abstract] [Full Text] [PDF]  

Wenbo Zhang, Jean-Marc Navenot, Nicole M. Frilot, Nobutaka Fujii, and Stephen C. Peiper

Association of Nucleophosmin Negatively Regulates CXCR4-Mediated G Protein Activation and Chemotaxis
Mol Pharmacol 2007 72: 1310-1321. Published online August 22, 2007; 10.1124/mol.107.037119 [Abstract] [Full Text] [PDF]  

Vernon Twede, Anthony L. Tartaglia, Douglas F. Covey, and Bruce A. Bamber

The Neurosteroids Dehydroepiandrosterone Sulfate and Pregnenolone Sulfate Inhibit the UNC-49 GABA Receptor through a Common Set of Residues
Mol Pharmacol 2007 72: 1322-1329. Published online August 22, 2007; 10.1124/mol.107.034058 [Abstract] [Full Text] [PDF]  

Ana M. Pajor and Kathleen M. Randolph

Inhibition of the Na⁺/Dicarboxylate Cotransporter by Anthranilic Acid Derivatives
Mol Pharmacol 2007 72: 1330-1336. Published online August 22, 2007; 10.1124/mol.107.035352 [Abstract] [Full Text] [PDF]  

Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao, and Masanori Kitamura

Geranylgeranylacetone, an Inducer of the 70-kDa Heat Shock Protein (HSP70), Elicits Unfolded Protein Response and Coordinates Cellular Fate Independently of HSP70
Mol Pharmacol 2007 72: 1337-1348. Published online August 16, 2007; 10.1124/mol.107.039164 [Abstract] [Full Text] [PDF]  

Xiaoyu Qu, Richard P. Metz, Weston W. Porter, Vincent M. Cassone, and David J. Earnest

Disruption of Clock Gene Expression Alters Responses of the Aryl Hydrocarbon Receptor Signaling Pathway in the Mouse Mammary Gland
Mol Pharmacol 2007 72: 1349-1358. Published online August 22, 2007; 10.1124/mol.107.039305 [Abstract] [Full Text] [PDF]  

Masaaki Sato, Takahiro Horinouchi, Dana S. Hutchinson, Bronwyn A. Evans, and Roger J. Summers

Ligand-Directed Signaling at the ₃-Adrenoceptor Produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) Relative to Receptor Agonists
Mol Pharmacol 2007 72: 1359-1368. Published online August 23, 2007; 10.1124/mol.107.035337 [Abstract] [Full Text] [PDF]  

Christopher R. Chiaro, Rushang D. Patel, Craig B. Marcus, and Gary H. Perdew

Evidence for an Aryl Hydrocarbon Receptor-Mediated Cytochrome P450 Autoregulatory Pathway
Mol Pharmacol 2007 72: 1369-1379. Published online August 24, 2007; 10.1124/mol.107.038968 [Abstract] [Full Text] [PDF]  

Kah Poh Tan, Mingdong Yang, and Shinya Ito

Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress
Mol Pharmacol 2007 72: 1380-1390. Published online August 27, 2007; 10.1124/mol.107.039370 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Pharmacological Characterization of a Novel Nonpeptide Antagonist for Formyl Peptide Receptor-Like 1"
Mol Pharmacol 2007 72: 1391. [Full Text] [PDF]  

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