Mol Pharm -- Table of Contents (72 [6])

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December 2007; 72 (6)   [Index by Author] [Cover Caption]

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Minireview:

Terry Kenakin: Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?
Mol Pharmacol 2007 72: 1393-1401. Published online September 27, 2007; 10.1124/mol.107.040352 [Abstract] [Full Text] [PDF]

Perspective:

George R. Dubyak: Go It Alone No More—P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels
Mol Pharmacol 2007 72: 1402-1405. Published online September 25, 2007; 10.1124/mol.107.042077 [Abstract] [Full Text] [PDF] [Related Article]

Accelerated Communications:

S. T. Nevin, R. J. Clark, H. Klimis, M. J. Christie, D. J. Craik, and D. J. Adams: Are ${alpha}$ 9 ${alpha}$ 10 Nicotinic Acetylcholine Receptors a Pain Target for ${alpha}$ -Conotoxins?
Mol Pharmacol 2007 72: 1406-1410. Published online September 5, 2007; 10.1124/mol.107.040568 [Abstract] [Full Text] [PDF]

Bruno P. Guiard, Jean-Philippe Guilloux, Christelle Reperant, Stephen P. Hunt, Miklos Toth, and Alain M. Gardier: Substance P Neurokinin 1 Receptor Activation within the Dorsal Raphe Nucleus Controls Serotonin Release in the Mouse Frontal Cortex
Mol Pharmacol 2007 72: 1411-1418. Published online September 21, 2007; 10.1124/mol.107.040113 [Abstract] [Full Text] [PDF]

Miroslav Dostalek, Joshua D. Brooks, Klarissa D. Hardy, Ginger L. Milne, Megan M. Moore, Sameer Sharma, Jason D. Morrow, and F. Peter Guengerich: In Vivo Oxidative Damage in Rats Is Associated with Barbiturate Response but Not Other Cytochrome P450 Inducers
Mol Pharmacol 2007 72: 1419-1424. Published online September 26, 2007; 10.1124/mol.107.040238 [Abstract] [Full Text] [PDF] [Data Supplement]

Articles:

Annie Quan, Andrew B. McGeachie, Damien J. Keating, Ellen M. van Dam, Jenny Rusak, Ngoc Chau, Chandra S. Malladi, Chen Chen, Adam McCluskey, Michael A. Cousin, and Phillip J. Robinson: Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II
Mol Pharmacol 2007 72: 1425-1439. Published online August 16, 2007; 10.1124/mol.107.034207 [Abstract] [Full Text] [PDF] [Data Supplement]

Philip K. Tan, Jean Wang, Pey-Lih H. Littler, Kenneth K. Wong, Timothy A. Sweetnam, William Keefe, Norman R. Nash, Esther C. Reding, Fabrice Piu, Mark R. Brann, and Hans H. Schiffer: Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2007 72: 1440-1446. Published online August 22, 2007; 10.1124/mol.107.039636 [Abstract] [Full Text] [PDF] [Data Supplement]

Chang Guo, Marianela Masin, Omar S. Qureshi, and Ruth D. Murrell-Lagnado: Evidence for Functional P2X₄/P2X₇ Heteromeric Receptors
Mol Pharmacol 2007 72: 1447-1456. Published online September 4, 2007; 10.1124/mol.107.035980 [Abstract] [Full Text] [PDF] [Data Supplement]

Steven T. Okino, Linda C. Quattrochi, Deepa Pookot, Mieko Iwahashi, and Rajvir Dahiya: A Dioxin-Responsive Enhancer 3' of the Human CYP1A2 Gene
Mol Pharmacol 2007 72: 1457-1465. Published online September 4, 2007; 10.1124/mol.107.039826 [Abstract] [Full Text] [PDF] [Data Supplement]

Dhruv Sareen, Soesiawati R. Darjatmoko, Daniel M. Albert, and Arthur S. Polans: Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer
Mol Pharmacol 2007 72: 1466-1475. Published online September 11, 2007; 10.1124/mol.107.039040 [Abstract] [Full Text] [PDF]

Xin-Kang Tong and Edith Hamel: Transforming Growth Factor- $beta$ 1 Impairs Endothelin-1-Mediated Contraction of Brain Vessels by Inducing Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 and Inhibiting p38 MAP Kinase
Mol Pharmacol 2007 72: 1476-1483. Published online September 11, 2007; 10.1124/mol.107.039602 [Abstract] [Full Text] [PDF]

J. Alex Goodwin, Edward C. Hulme, Christopher J. Langmead, and Ben G. Tehan: Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands
Mol Pharmacol 2007 72: 1484-1496. Published online September 11, 2007; 10.1124/mol.107.038265 [Abstract] [Full Text] [PDF] [Data Supplement]

Maurine Delhaye, Audrey Gravot, Diana Ayinde, Florence Niedergang, Marc Alizon, and Anne Brelot: Identification of a Postendocytic Sorting Sequence in CCR5
Mol Pharmacol 2007 72: 1497-1507. Published online September 12, 2007; 10.1124/mol.107.038422 [Abstract] [Full Text] [PDF]

Narendra P. Singh, Venkatesh L. Hegde, Lorne J. Hofseth, Mitzi Nagarkatti, and Prakash Nagarkatti: Resveratrol (trans-3,5,4'-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor
Mol Pharmacol 2007 72: 1508-1521. Published online September 14, 2007; 10.1124/mol.107.038984 [Abstract] [Full Text] [PDF]

Jodene Eldstrom, Zhuren Wang, Hongjian Xu, Marc Pourrier, Alan Ezrin, Ken Gibson, and David Fedida: The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels
Mol Pharmacol 2007 72: 1522-1534. Published online September 14, 2007; 10.1124/mol.107.039388 [Abstract] [Full Text] [PDF]

Christian Madry, Ivana Mesic, Heinrich Betz, and Bodo Laube: The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn²⁺ Inhibition and Glycine Affinity of N-Methyl-D-aspartate Receptors
Mol Pharmacol 2007 72: 1535-1544. Published online September 18, 2007; 10.1124/mol.107.040071 [Abstract] [Full Text] [PDF]

Virginie Aires, Aziz Hichami, Rodolphe Filomenko, Aude Plé, Cédric Rébé, Ali Bettaieb, and Naim Akhtar Khan: Docosahexaenoic Acid Induces Increases in [Ca²⁺]_i via Inositol 1,4,5-Triphosphate Production and Activates Protein Kinase C ${gamma}$ and - ${delta}$ via Phosphatidylserine Binding Site: Implication in Apoptosis in U937 Cells
Mol Pharmacol 2007 72: 1545-1556. Published online September 18, 2007; 10.1124/mol.107.039792 [Abstract] [Full Text] [PDF]

Jason L. Niehaus, Yunguang Liu, Kathleen T. Wallis, Michaela Egertová, Sheela G. Bhartur, Somnath Mukhopadhyay, Shanping Shi, Hengjun He, Dana E. Selley, Allyn C. Howlett, Maurice R. Elphick, and Deborah L. Lewis: CB₁ Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a
Mol Pharmacol 2007 72: 1557-1566. Published online September 25, 2007; 10.1124/mol.107.039263 [Abstract] [Full Text] [PDF]

Anupama Gopalakrishnan, Michael Sievert, and Arnold E. Ruoho: Identification of the Substrate Binding Region of Vesicular Monoamine Transporter-2 (VMAT-2) Using Iodoaminoflisopolol as a Novel Photoprobe
Mol Pharmacol 2007 72: 1567-1575. Published online August 31, 2007; 10.1124/mol.107.034439 [Abstract] [Full Text] [PDF]

Xiao-Qing Dai, Alkarim Ramji, Yan Liu, Qiang Li, Edward Karpinski, and Xing-Zhen Chen: Inhibition of TRPP3 Channel by Amiloride and Analogs
Mol Pharmacol 2007 72: 1576-1585. Published online September 5, 2007; 10.1124/mol.107.037150 [Abstract] [Full Text] [PDF]

Jinsang Yoo and Yong J. Lee: Aspirin Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-Regulation
Mol Pharmacol 2007 72: 1586-1592. Published online September 11, 2007; 10.1124/mol.107.039610 [Abstract] [Full Text] [PDF]

Nicola Solaroli, Xinyu Zheng, Magnus Johansson, Jan Balzarini, and Anna Karlsson: Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase
Mol Pharmacol 2007 72: 1593-1598. Published online September 12, 2007; 10.1124/mol.107.037051 [Abstract] [Full Text] [PDF]

Gyu-Yong Song, Jee-Hyun Lee, Munju Cho, Byeoung-Soo Park, Dong-Eun Kim, and Sangtaek Oh: Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of $beta$ -Catenin
Mol Pharmacol 2007 72: 1599-1606. Published online September 12, 2007; 10.1124/mol.107.040253 [Abstract] [Full Text] [PDF]

Jing Pan, Gang Wang, Hong-Qi Yang, Zhen Hong, Qin Xiao, Ru-Jing Ren, Hai-Yan Zhou, Li Bai, and Sheng-Di Chen: K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH₂-Terminal Kinase 3 (JNK3) and Apoptosis-Inducing Kinase 1/JNK3 Signaling Pathways
Mol Pharmacol 2007 72: 1607-1618. Published online September 13, 2007; 10.1124/mol.107.038463 [Abstract] [Full Text] [PDF]

Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Insook Kim, Kunio Shiota, Frank J. Gonzalez, and Yuichi Sugiyama: Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 ${alpha}$ / $beta$ and DNA Methylation
Mol Pharmacol 2007 72: 1619-1625. Published online September 13, 2007; 10.1124/mol.107.039701 [Abstract] [Full Text] [PDF]

Jiantu Che, Edwin S. L. Chan, and Bruce N. Cronstein: Adenosine A_2A Receptor Occupancy Stimulates Collagen Expression by Hepatic Stellate Cells via Pathways Involving Protein Kinase A, Src, and Extracellular Signal-Regulated Kinases 1/2 Signaling Cascade or p38 Mitogen-Activated Protein Kinase Signaling Pathway
Mol Pharmacol 2007 72: 1626-1636. Published online September 14, 2007; 10.1124/mol.107.038760 [Abstract] [Full Text] [PDF] [Data Supplement]

Ruqing Liu, Paul E. Blower, Anh-Nhan Pham, Jialong Fang, Zunyan Dai, Carolyn Wise, Bridgette Green, Candee H. Teitel, Baitang Ning, Wenhua Ling, Beverly D. Lyn-Cook, Fred F. Kadlubar, Wolfgang Sadée, and Ying Huang: Cystine-Glutamate Transporter SLC7A11 Mediates Resistance to Geldanamycin but Not to 17-(Allylamino)-17-demethoxygeldanamycin
Mol Pharmacol 2007 72: 1637-1646. Published online September 17, 2007; 10.1124/mol.107.039644 [Abstract] [Full Text] [PDF] [Data Supplement]

Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Bernd Heimrich, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Alexander Hoetzel, Torsten Loop, Heike L. Pahl, Klaus K. Geiger, and Benedikt H. J. Pannen: Repression of T-Cell Function by Thionamides Is Mediated by Inhibition of the Activator Protein-1/Nuclear Factor of Activated T-Cells Pathway and Is Associated with a Common Structure
Mol Pharmacol 2007 72: 1647-1656. Published online September 18, 2007; 10.1124/mol.107.038141 [Abstract] [Full Text] [PDF]

Arieh Moussaieff, Esther Shohami, Yoel Kashman, Ester Fride, M. Lienhard Schmitz, Florian Renner, Bernd L. Fiebich, Eduardo Munoz, Yinon Ben-Neriah, and Raphael Mechoulam: Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor- ${kappa}$ B Activation
Mol Pharmacol 2007 72: 1657-1664. Published online September 25, 2007; 10.1124/mol.107.038810 [Abstract] [Full Text] [PDF] [Data Supplement]

Cover Caption:

About the cover: Composite of double-immunostaining showing the induction of MKP-1 (Cy2, green) by transforming growth factor-β1 (TGF-β1) in brain vascular SMC cells (SMC-actin, Cy3, red). See the article by Tong and Hamel on page 1476 of this issue.