Mol Pharm -- Table of Contents (73 [2])

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February 2008; 73 (2)   [Index by Author] [Cover Caption]

       Perspective

       Accelerated Communication

       Articles

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Perspective:

Joseph N. Contessa and Daniel A. Hamstra: Revoking the Privilege: Targeting HER2 in the Central Nervous System
Mol Pharmacol 2008 73: 271-273. Published online November 2, 2007; 10.1124/mol.107.042986 [Abstract] [Full Text] [PDF] [Related Article]

Accelerated Communication:

Thomas E. Taylor-Clark, Bradley J. Undem, Donald W. MacGlashan, Jr., Srinivas Ghatta, Michael J. Carr, and M. Allen McAlexander: Prostaglandin-Induced Activation of Nociceptive Neurons via Direct Interaction with Transient Receptor Potential A1 (TRPA1)
Mol Pharmacol 2008 73: 274-281. Published online November 13, 2007; 10.1124/mol.107.040832 [Abstract] [Full Text] [PDF]

Articles:

A. Zeller, F. Crestani, I. Camenisch, T. Iwasato, S. Itohara, J. M. Fritschy, and U. Rudolph: Cortical Glutamatergic Neurons Mediate the Motor Sedative Action of Diazepam
Mol Pharmacol 2008 73: 282-291. Published online October 26, 2007; 10.1124/mol.107.038828 [Abstract] [Full Text] [PDF]

Q. Liu, D. A. Dewi, W. Liu, M. S. Bee, and A. Schonbrunn: Distinct Phosphorylation Sites in the SST2A Somatostatin Receptor Control Internalization, Desensitization, and Arrestin Binding
Mol Pharmacol 2008 73: 292-304. Published online November 2, 2007; 10.1124/mol.107.038570 [Abstract] [Full Text] [PDF]

Naissan Hussainzada, Akash Khandewal, and Peter W. Swaan: Conformational Flexibility of Helix VI Is Essential for Substrate Permeation of the Human Apical Sodium-Dependent Bile Acid Transporter
Mol Pharmacol 2008 73: 305-313. Published online October 30, 2007; 10.1124/mol.107.041640 [Abstract] [Full Text] [PDF]

Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang: Anandamide Inhibition of 5-HT_3A Receptors Varies with Receptor Density and Desensitization
Mol Pharmacol 2008 73: 314-322. Published online November 9, 2007; 10.1124/mol.107.039149 [Abstract] [Full Text] [PDF]

Salvatore Cuzzocrea, Stefano Bruscoli, Emanuela Mazzon, Concetta Crisafulli, Valerio Donato, Rosanna Di Paola, Enrico Velardi, Emanuela Esposito, Giuseppe Nocentini, and Carlo Riccardi: Peroxisome Proliferator-Activated Receptor- ${alpha}$ Contributes to the Anti-Inflammatory Activity of Glucocorticoids
Mol Pharmacol 2008 73: 323-337. Published online November 5, 2007; 10.1124/mol.107.041475 [Abstract] [Full Text] [PDF] [Data Supplement]

Stuart L. Emanuel, Terry V. Hughes, Mary Adams, Catherine A. Rugg, Angel Fuentes-Pesquera, Peter J. Connolly, Niranjan Pandey, Sandra Moreno-Mazza, Jeannene Butler, Virna Borowski, Steven A. Middleton, Robert H. Gruninger, Jennifer R. Story, Cheryl Napier, Beth Hollister, and Lee M. Greenberger: Cellular and in Vivo Activity of JNJ-28871063, A Nonquinazoline Pan-ErbB Kinase Inhibitor That Crosses the Blood-Brain Barrier and Displays Efficacy against Intracranial Tumors
Mol Pharmacol 2008 73: 338-348. Published online November 1, 2007; 10.1124/mol.107.041236 [Abstract] [Full Text] [PDF]

Rasmus Jorgensen, Nicholas D. Holliday, Jakob L. Hansen, Milka Vrecl, Anders Heding, Thue W. Schwartz, and Christian E. Elling: Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2008 73: 349-358. Published online November 6, 2007; 10.1124/mol.107.038877 [Abstract] [Full Text] [PDF] [Data Supplement]

Shengwei Zou, Smita Jha, Eun Young Kim, and Stuart E. Dryer: A Novel Actin-Binding Domain on Slo1 Calcium-Activated Potassium Channels Is Necessary for Their Expression in the Plasma Membrane
Mol Pharmacol 2008 73: 359-368. Published online November 7, 2007; 10.1124/mol.107.039743 [Abstract] [Full Text] [PDF]

Shengwei Zou, Smita Jha, Eun Young Kim, and Stuart E. Dryer: The β1 Subunit of L-Type Voltage-Gated Ca²⁺ Channels Independently Binds to and Inhibits the Gating of Large-Conductance Ca²⁺-Activated K⁺ Channels
Mol Pharmacol 2008 73: 369-378. Published online November 7, 2007; 10.1124/mol.107.040733 [Abstract] [Full Text] [PDF]

Ekaitz Errasti-Murugarren, Pedro Cano-Soldado, Marçal Pastor-Anglada, and Fco Javier Casado: Functional Characterization of a Nucleoside-Derived Drug Transporter Variant (hCNT3_C602R) Showing Altered Sodium-Binding Capacity
Mol Pharmacol 2008 73: 379-386. Published online November 9, 2007; 10.1124/mol.107.041848 [Abstract] [Full Text] [PDF]

Brad R. Evans, Sibel I. Karchner, Lenka L. Allan, Richard S. Pollenz, Robert L. Tanguay, Matthew J. Jenny, David H. Sherr, and Mark E. Hahn: Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator
Mol Pharmacol 2008 73: 387-398. Published online November 13, 2007; 10.1124/mol.107.040204 [Abstract] [Full Text] [PDF]

Yumei Fu, Shizhong Zheng, Jianguo Lin, Jan Ryerse, and Anping Chen: Curcumin Protects the Rat Liver from CCl₄-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation
Mol Pharmacol 2008 73: 399-409. Published online November 15, 2007; 10.1124/mol.107.039818 [Abstract] [Full Text] [PDF]

D. M. Lehmann, A. M. P. B. Seneviratne, and A. V. Smrcka: Small Molecule Disruption of G Protein β ${gamma}$ Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation
Mol Pharmacol 2008 73: 410-418. Published online November 15, 2007; 10.1124/mol.107.041780 [Abstract] [Full Text] [PDF]

Lisa M. Greene, Giuseppe Campiani, Mark Lawler, D. Clive Williams, and Daniela M. Zisterer: BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines
Mol Pharmacol 2008 73: 419-430. Published online November 8, 2007; 10.1124/mol.107.039024 [Abstract] [Full Text] [PDF] [Data Supplement]

Marie Parat, Normand McNicoll, Brian Wilkes, Alain Fournier, and André De Léan: Role of Extracellular Domain Dimerization in Agonist-Induced Activation of Natriuretic Peptide Receptor A
Mol Pharmacol 2008 73: 431-440. Published online October 26, 2007; 10.1124/mol.107.039982 [Abstract] [Full Text] [PDF]

Douglas McHugh, Carolyn Tanner, Raphael Mechoulam, Roger G. Pertwee, and Ruth A. Ross: Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB₁ and CB₂
Mol Pharmacol 2008 73: 441-450. Published online October 26, 2007; 10.1124/mol.107.041863 [Abstract] [Full Text] [PDF]

Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc Pascussi, Marie-Josée Vilarem, Patrick Maurel, and Gordon M. Kirby: Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4 ${alpha}$ to the Proximal Promoter
Mol Pharmacol 2008 73: 451-460. Published online October 31, 2007; 10.1124/mol.107.039354 [Abstract] [Full Text] [PDF]

Roohangiz Safaei, Shinji Otani, Barrett J. Larson, Michael L. Rasmussen, and Stephen B. Howell: Transport of Cisplatin by the Copper Efflux Transporter ATP7B
Mol Pharmacol 2008 73: 461-468. Published online October 31, 2007; 10.1124/mol.107.040980 [Abstract] [Full Text] [PDF]

Ivar von Kügelgen, Anke C. Schiedel, Kristina Hoffmann, Bernt B. A. Alsdorf, Aliaa Abdelrahman, and Christa E. Müller: Cloning and Functional Expression of a Novel G_i Protein-Coupled Receptor for Adenine from Mouse Brain
Mol Pharmacol 2008 73: 469-477. Published online November 1, 2007; 10.1124/mol.107.037069 [Abstract] [Full Text] [PDF]

Renaud Robert, Graeme W. Carlile, Catalin Pavel, Na Liu, Suzana M. Anjos, Jie Liao, Yishan Luo, Donglei Zhang, David Y. Thomas, and John W. Hanrahan: Structural Analog of Sildenafil Identified as a Novel Corrector of the F508del-CFTR Trafficking Defect
Mol Pharmacol 2008 73: 478-489. Published online November 1, 2007; 10.1124/mol.107.040725 [Abstract] [Full Text] [PDF]

Zhiyong Liao, Robert W. Robey, Josée Guirouilh-Barbat, Kenneth K. W. To, Orsolya Polgar, Susan E. Bates, and Yves Pommier: Reduced Expression of DNA Topoisomerase I in SF295 Human Glioblastoma Cells Selected for Resistance to Homocamptothecin and Diflomotecan
Mol Pharmacol 2008 73: 490-497. Published online November 5, 2007; 10.1124/mol.107.041178 [Abstract] [Full Text] [PDF]

Laura Papucci, Ewa Witort, Anna Maria Bevilacqua, Martino Donnini, Matteo Lulli, Elisabetta Borchi, Khalid S. A. Khabar, Alessio Tempestini, Andrea Lapucci, Nicola Schiavone, Angelo Nicolin, and Sergio Capaccioli: Impact of Targeting the Adenine- and Uracil-Rich Element of bcl-2 mRNA with Oligoribonucleotides on Apoptosis, Cell Cycle, and Neuronal Differentiation in SHSY-5Y Cells
Mol Pharmacol 2008 73: 498-508. Published online November 7, 2007; 10.1124/mol.107.038323 [Abstract] [Full Text] [PDF]

Ralph Krätzner, Florian Fröhlich, Katrin Lepler, Michaela Schröder, Katharina Röher, Corinna Dickel, Mladen V. Tzvetkov, Thomas Quentin, Elke Oetjen, and Willhart Knepel: A Peroxisome Proliferator-Activated Receptor ${gamma}$ -Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription
Mol Pharmacol 2008 73: 509-517. Published online October 25, 2007; 10.1124/mol.107.035568 [Abstract] [Full Text] [PDF]

Laura H. Heitman, Julia Oosterom, Kimberly M. Bonger, Cornelis M. Timmers, Peter H. G. Wiegerinck, and Adriaan P. IJzerman: [³H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor
Mol Pharmacol 2008 73: 518-524. Published online November 7, 2007; 10.1124/mol.107.039875 [Abstract] [Full Text] [PDF]

Andrew Holt, David J. Smith, Laura Cendron, Giuseppe Zanotti, Adelio Rigo, and Maria Luisa Di Paolo: Multiple Binding Sites for Substrates and Modulators of Semicarbazide-Sensitive Amine Oxidases: Kinetic Consequences
Mol Pharmacol 2008 73: 525-538. Published online November 7, 2007; 10.1124/mol.107.040964 [Abstract] [Full Text] [PDF] [Data Supplement]

Paul D. Upton, Lu Long, Richard C. Trembath, and Nicholas W. Morrell: Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells
Mol Pharmacol 2008 73: 539-552. Published online November 7, 2007; 10.1124/mol.107.041673 [Abstract] [Full Text] [PDF] [Data Supplement]

Sabitha Papineni, Sudhakar Chintharlapalli, and Stephen Safe: Methyl 2-Cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate Is a Peroxisome Proliferator-Activated Receptor- ${gamma}$ Agonist That Induces Receptor-Independent Apoptosis in LNCaP Prostate Cancer Cells
Mol Pharmacol 2008 73: 553-565. Published online November 7, 2007; 10.1124/mol.107.041285 [Abstract] [Full Text] [PDF]

Anna M. Misior, Huandong Yan, Rodolfo M. Pascual, Deepak A. Deshpande, Reynold A. Panettieri, and Raymond B. Penn: Mitogenic Effects of Cytokines on Smooth Muscle Are Critically Dependent on Protein Kinase A and Are Unmasked by Steroids and Cyclooxygenase Inhibitors
Mol Pharmacol 2008 73: 566-574. Published online November 9, 2007; 10.1124/mol.107.040519 [Abstract] [Full Text] [PDF]

Elin Swedenborg, Joëlle Rüegg, Anne Hillenweck, Stefan Rehnmark, Malin Hedengran Faulds, Daniel Zalko, Ingemar Pongratz, and Katarina Pettersson: 3-Methylcholanthrene Displays Dual Effects on Estrogen Receptor (ER) ${alpha}$ and ERβ Signaling in a Cell-Type Specific Fashion
Mol Pharmacol 2008 73: 575-586. Published online November 14, 2007; 10.1124/mol.107.036384 [Abstract] [Full Text] [PDF] [Data Supplement]

Chenqi Zhao, Maria J. Fernandes, Glenn D. Prestwich, Mélanie Turgeon, John Di Battista, Timothy Clair, Patrice E. Poubelle, and Sylvain G. Bourgoin: Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?
Mol Pharmacol 2008 73: 587-600. Published online November 15, 2007; 10.1124/mol.107.038216 [Abstract] [Full Text] [PDF]

Jessica Radzio and Nicolas Sluis-Cremer: Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision
Mol Pharmacol 2008 73: 601-606. Published online November 16, 2007; 10.1124/mol.107.038596 [Abstract] [Full Text] [PDF]

Keith R. Stayrook, Pamela M. Rogers, Rajesh S. Savkur, Yongjun Wang, Chen Su, Gabor Varga, Xin Bu, Tao Wei, Sunil Nagpal, Xiaole Shirley Liu, and Thomas P. Burris: Regulation of Human 3 ${alpha}$ -Hydroxysteroid Dehydrogenase (AKR1C4) Expression by the Liver X Receptor ${alpha}$
Mol Pharmacol 2008 73: 607-612. Published online November 16, 2007; 10.1124/mol.107.039099 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Region- and cell type-specific loss of α1 subunit IR in forebrain-specific α1−/− mice. See the article by Zeller et al., on page 282 of this issue.