Mol Pharm -- Table of Contents (73 [4])

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April 2008; 73 (4)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Accelerated Communication:

Steven Gu, Sam Tirgari, and Scott P. Heximer: The RGS2 Gene Product from a Candidate Hypertension Allele Shows Decreased Plasma Membrane Association and Inhibition of G_q
Mol Pharmacol 2008 73: 1037-1043. Published online January 29, 2008; 10.1124/mol.107.044214 [Abstract] [Full Text] [PDF] [Data Supplement]

Articles:

Matthew Perry and Michael C. Sanguinetti: A Single Amino Acid Difference between Ether-a-go-go- Related Gene Channel Subtypes Determines Differential Sensitivity to a Small Molecule Activator
Mol Pharmacol 2008 73: 1044-1051. Published online December 27, 2007; 10.1124/mol.107.043018 [Abstract] [Full Text] [PDF]

Matthew A. King, Sarah Hands, Farida Hafiz, Noboru Mizushima, Aviva M. Tolkovsky, and Andreas Wyttenbach: Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis
Mol Pharmacol 2008 73: 1052-1063. Published online January 16, 2008; 10.1124/mol.107.043398 [Abstract] [Full Text] [PDF] [Data Supplement]

Dinesh Puppala, Hyosung Lee, Kyung Bo Kim, and Hollie I. Swanson: Development of an Aryl Hydrocarbon Receptor Antagonist Using the Proteolysis-Targeting Chimeric Molecules Approach: A Potential Tool for Chemoprevention
Mol Pharmacol 2008 73: 1064-1071. Published online January 4, 2008; 10.1124/mol.107.040840 [Abstract] [Full Text] [PDF]

Adam B. Weinglass, Martin G. Köhler, Emmanuel O. Nketiah, Jessica Liu, William Schmalhofer, Anu Thomas, Brande Williams, Lindsey Beers, Lauren Smith, Mike Hafey, Kelly Bleasby, Joseph Leone, Yui Sing Tang, Matthew Braun, Feroze Ujjainwalla, Margaret E. McCann, Gregory J. Kaczorowski, and Maria L. Garcia: Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake
Mol Pharmacol 2008 73: 1072-1084. Published online January 10, 2008; 10.1124/mol.107.043844 [Abstract] [Full Text] [PDF]

Wibke Singer, Rama Panford-Walsh, Dirk Watermann, Oliver Hendrich, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock, and Marlies Knipper: Salicylate Alters the Expression of Calcium Response Transcription Factor 1 in the Cochlea: Implications for Brain-Derived Neurotrophic Factor Transcriptional Regulation
Mol Pharmacol 2008 73: 1085-1091. Published online January 15, 2008; 10.1124/mol.107.041814 [Abstract] [Full Text] [PDF] [Data Supplement]

R. Peter Riek, Angela A. Finch, Gillian E. Begg, and Robert M. Graham: Wide Turn Diversity in Protein Transmembrane Helices Implications for G-Protein-Coupled Receptor and Other Polytopic Membrane Protein Structure and Function
Mol Pharmacol 2008 73: 1092-1104. Published online January 17, 2008; 10.1124/mol.107.043042 [Abstract] [Full Text] [PDF] [Data Supplement]

Lina Yao, Peidong Fan, Zhan Jiang, Adrienne Gordon, Daria Mochly-Rosen, and Ivan Diamond: Dopamine and Ethanol Cause Translocation of ${epsilon}$ PKC Associated with ${epsilon}$ RACK: Cross-Talk between cAMP-Dependent Protein Kinase A and Protein Kinase C Signaling Pathways
Mol Pharmacol 2008 73: 1105-1112. Published online January 17, 2008; 10.1124/mol.107.042580 [Abstract] [Full Text] [PDF]

Tatsuya Sueyoshi, Rick Moore, Junko Sugatani, Yonehiro Matsumura, and Masahiko Negishi: PPP1R16A, The Membrane Subunit of Protein Phosphatase 1β, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor
Mol Pharmacol 2008 73: 1113-1121. Published online January 17, 2008; 10.1124/mol.107.042960 [Abstract] [Full Text] [PDF]

Thien-An Nguyen, Marina Tychopoulos, Florence Bichat, Clothilde Zimmermann, Jean-Pierre Flinois, Monique Diry, Emelie Ahlberg, Marcel Delaforge, Laurent Corcos, Philippe Beaune, Patrick Dansette, François André, and Isabelle de Waziers: Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo
Mol Pharmacol 2008 73: 1122-1133. Published online January 22, 2008; 10.1124/mol.107.042861 [Abstract] [Full Text] [PDF] [Data Supplement]

Francesco Tadini-Buoninsegni, Gianluca Bartolommei, Maria Rosa Moncelli, Daniel M. Tal, David Lewis, and Giuseppe Inesi: Effects of High-Affinity Inhibitors on Partial Reactions, Charge Movements, and Conformational States of the Ca²⁺ Transport ATPase (Sarco-Endoplasmic Reticulum Ca²⁺ ATPase)
Mol Pharmacol 2008 73: 1134-1140. Published online January 22, 2008; 10.1124/mol.107.043745 [Abstract] [Full Text] [PDF]

M. Laura Parnas, Jon D. Gaffaney, Mu Fa Zou, John R. Lever, Amy Hauck Newman, and Roxanne A. Vaughan: Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand N-[4-(4-Azido-3-[¹²⁵I]iodophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane Implicates Proximity of Cocaine and Substrate Active Sites
Mol Pharmacol 2008 73: 1141-1150. Published online January 23, 2008; 10.1124/mol.107.043679 [Abstract] [Full Text] [PDF]

Cheryl D. Cropp, Takafumi Komori, James E. Shima, Thomas J. Urban, Sook Wah Yee, Swati S. More, and Kathleen M. Giacomini: Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP
Mol Pharmacol 2008 73: 1151-1158. Published online January 23, 2008; 10.1124/mol.107.043117 [Abstract] [Full Text] [PDF]

David Fernandez, John Sargent, Frank B. Sachse, and Michael C. Sanguinetti: Structural Basis for Ether-a-go-go-Related Gene K⁺ Channel Subtype-Dependent Activation by Niflumic Acid
Mol Pharmacol 2008 73: 1159-1167. Published online January 24, 2008; 10.1124/mol.107.043505 [Abstract] [Full Text] [PDF] [Data Supplement]

Margaret A. Park, Adly Yacoub, Mohammed Rahmani, Guo Zhang, Lori Hart, Michael P. Hagan, Stuart K. Calderwood, Michael Y. Sherman, Costas Koumenis, Sarah Spiegel, Ching-Shih Chen, Martin Graf, David T. Curiel, Paul B. Fisher, Steven Grant, and Paul Dent: OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells
Mol Pharmacol 2008 73: 1168-1184. Published online January 8, 2008; 10.1124/mol.107.042697 [Abstract] [Full Text] [PDF]

Chuan Wang, Uyenlinh L. Mirshahi, Boyi Liu, Zhanfeng Jia, Tooraj Mirshahi, and Hailin Zhang: Arachidonic Acid Activates Kir2.3 Channels by Enhancing Channel-Phosphatidyl-inositol 4,5-bisphosphate Interactions
Mol Pharmacol 2008 73: 1185-1194. Published online January 17, 2008; 10.1124/mol.107.043067 [Abstract] [Full Text] [PDF]

Xiao-Bing Zhang, Guang-Chun Sun, Lu-Ying Liu, Fang Yu, and Tian-Le Xu: ${alpha}$ 2 Subunit Specificity of Cyclothiazide Inhibition on Glycine Receptors
Mol Pharmacol 2008 73: 1195-1202. Published online December 27, 2007; 10.1124/mol.107.042655 [Abstract] [Full Text] [PDF] [Erratum]

Gennady Cherednichenko, Chris W. Ward, Wei Feng, Elaine Cabrales, Luke Michaelson, Montserrat Samso, José R. López, Paul D. Allen, and Isaac N. Pessah: Enhanced Excitation-Coupled Calcium Entry in Myotubes Expressing Malignant Hyperthermia Mutation R163C Is Attenuated by Dantrolene
Mol Pharmacol 2008 73: 1203-1212. Published online January 2, 2008; 10.1124/mol.107.043299 [Abstract] [Full Text] [PDF]

Colleen M. Niswender, Kari A. Johnson, Qingwei Luo, Jennifer E. Ayala, Caroline Kim, P. Jeffrey Conn, and C. David Weaver: A Novel Assay of G_i/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors
Mol Pharmacol 2008 73: 1213-1224. Published online January 2, 2008; 10.1124/mol.107.041053 [Abstract] [Full Text] [PDF]

Michael Maher, Hong Ao, Tue Banke, Nadia Nasser, Nyan-Tsz Wu, J. Guy Breitenbucher, Sandra R. Chaplan, and Alan D. Wickenden: Activation of TRPA1 by Farnesyl Thiosalicylic Acid
Mol Pharmacol 2008 73: 1225-1234. Published online January 2, 2008; 10.1124/mol.107.042663 [Abstract] [Full Text] [PDF]

Frank Wunder, Annegret Rebmann, Andreas Geerts, and Bernd Kalthof: Pharmacological and Kinetic Characterization of Adrenomedullin 1 and Calcitonin Gene-Related Peptide 1 Receptor Reporter Cell Lines
Mol Pharmacol 2008 73: 1235-1243. Published online January 3, 2008; 10.1124/mol.107.042283 [Abstract] [Full Text] [PDF] [Data Supplement]

Mauro Tiso, Andreas Strub, Christian Hesslinger, Claire T. Kenney, Rainer Boer, and Dennis J. Stuehr: BYK191023 (2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) Is an NADPH- and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase
Mol Pharmacol 2008 73: 1244-1253. Published online January 4, 2008; 10.1124/mol.107.041319 [Abstract] [Full Text] [PDF]

Benayahu Elbaz, Ariella Alperovitch, Michael M. Gottesman, Chava Kimchi-Sarfaty, and Hannah Rahamimoff: Modulation of Na⁺-Ca²⁺ Exchanger Expression by Immunosuppressive Drugs Is Isoform-Specific
Mol Pharmacol 2008 73: 1254-1263. Published online January 8, 2008; 10.1124/mol.107.041582 [Abstract] [Full Text] [PDF]

Gemma Moncunill, Mercedes Armand-Ugón, Imma Clotet-Codina, Eduardo Pauls, Ester Ballana, Anuska Llano, Barbara Romagnoli, Jan W. Vrijbloed, Frank O. Gombert, Bonaventura Clotet, Steve De Marco, and José A. Esté: Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026
Mol Pharmacol 2008 73: 1264-1273. Published online January 8, 2008; 10.1124/mol.107.042911 [Abstract] [Full Text] [PDF] [Data Supplement]

Yijun Deng, Zhanjun Hou, Lei Wang, Christina Cherian, Jianmei Wu, Aleem Gangjee, and Larry H. Matherly: Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition
Mol Pharmacol 2008 73: 1274-1281. Published online January 8, 2008; 10.1124/mol.107.043190 [Abstract] [Full Text] [PDF] [Data Supplement]

Adrian Roth, Renate Looser, Michel Kaufmann, Sharon M. Blättler, Franck Rencurel, Wendong Huang, David D. Moore, and Urs A. Meyer: Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression
Mol Pharmacol 2008 73: 1282-1289. Published online January 10, 2008; 10.1124/mol.107.041012 [Abstract] [Full Text] [PDF]

Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A. Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, and Godefridus J. Peters: Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells
Mol Pharmacol 2008 73: 1290-1300. Published online January 10, 2008; 10.1124/mol.107.042382 [Abstract] [Full Text] [PDF]

Michael S. Virk and John T. Williams: Agonist-Specific Regulation of µ-Opioid Receptor Desensitization and Recovery from Desensitization
Mol Pharmacol 2008 73: 1301-1308. Published online January 15, 2008; 10.1124/mol.107.042952 [Abstract] [Full Text] [PDF] [Data Supplement]

Byung Hak Kim, Eunmiri Roh, Hwa Young Lee, In-Jeong Lee, Byeongwoo Ahn, Sang-Hun Jung, Heesoon Lee, Sang-Bae Han, and Youngsoo Kim: Benzoxathiole Derivative Blocks Lipopolysaccharide-Induced Nuclear Factor- ${kappa}$ B Activation and Nuclear Factor- ${kappa}$ B-Regulated Gene Transcription through Inactivating Inhibitory ${kappa}$ B Kinase β
Mol Pharmacol 2008 73: 1309-1318. Published online January 17, 2008; 10.1124/mol.107.041251 [Abstract] [Full Text] [PDF]

Jian-Guo Li, Dale S. Haines, and Lee-Yuan Liu-Chen: Agonist-Promoted Lys63-Linked Polyubiquitination of the Human ${kappa}$ -Opioid Receptor Is Involved in Receptor Down-Regulation
Mol Pharmacol 2008 73: 1319-1330. Published online January 22, 2008; 10.1124/mol.107.042846 [Abstract] [Full Text] [PDF] [Data Supplement]

Errata:

: Correction to "Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression"
Mol Pharmacol 2008 73: 1331. [Full Text] [PDF]

Cover Caption:

About the cover: CYP2B6 topology with the channels identified by CAVER based on various structures produced during the 2-ns MD simulations. See the article by Nguyen et al. on page 1122 of this issue.