Perspectives:

Raymond Evers and Xiao-Yan Chu

Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity
Mol Pharmacol 2008 74: 309-311. Published online May 20, 2008; 10.1124/mol.108.048991 [Abstract] [Full Text] [PDF] [Related Article]   

Vsevolod V. Gurevich and Eugenia V. Gurevich

Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms
Mol Pharmacol 2008 74: 312-316. Published online May 30, 2008; 10.1124/mol.108.049015 [Abstract] [Full Text] [PDF] [Related Article]   

Gregg D. Stanwood

Protein-Protein Interactions and Dopamine D₂ Receptor Signaling: A Calcium Connection
Mol Pharmacol 2008 74: 317-319. Published online May 29, 2008; 10.1124/mol.108.049098 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communications:

Hani Zaher, Henriette E. Meyer zu Schwabedissen, Rommel G. Tirona, Melissa L. Cox, Leslie A. Obert, Nidhi Agrawal, Joe Palandra, Jeffrey L. Stock, Richard B. Kim, and Joseph A. Ware

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin
Mol Pharmacol 2008 74: 320-329. Published online April 15, 2008; 10.1124/mol.108.046458 [Abstract] [Full Text] [PDF]  

Katrien O. François, Joeri Auwerx, Dominique Schols, and Jan Balzarini

Simian Immunodeficiency Virus Is Susceptible to Inhibition by Carbohydrate-Binding Agents in a Manner Similar to That of HIV: Implications for Further Preclinical Drug Development
Mol Pharmacol 2008 74: 330-337. Published online May 12, 2008; 10.1124/mol.108.047621 [Abstract] [Full Text] [PDF]  

Articles:

Jiansong Luo, John M. Busillo, and Jeffrey L. Benovic

M₃ Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms
Mol Pharmacol 2008 74: 338-347. Published online April 3, 2008; 10.1124/mol.107.044750 [Abstract] [Full Text] [PDF]  

Jane A. Dickinson, James N. C. Kew, and Susan Wonnacott

Presynaptic 7- and β2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms
Mol Pharmacol 2008 74: 348-359. Published online April 29, 2008; 10.1124/mol.108.046623 [Abstract] [Full Text] [PDF]  

Eunice Y. Yuen, Yi Ren, and Zhen Yan

Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-D-aspartate Receptors to Calpain Cleavage in Cortical Neurons
Mol Pharmacol 2008 74: 360-370. Published online April 29, 2008; 10.1124/mol.108.046813 [Abstract] [Full Text] [PDF]  

Yong Liu, David C. Buck, and Kim A. Neve

Novel Interaction of the Dopamine D₂ Receptor and the Ca²⁺ Binding Protein S100B: Role in D₂ Receptor Function
Mol Pharmacol 2008 74: 371-378. Published online April 29, 2008; 10.1124/mol.108.044925 [Abstract] [Full Text] [PDF]  

Jean-Charles Hoda, Wenli Gu, Marc Friedli, Hilary A. Phillips, Sonia Bertrand, Stylianos E. Antonarakis, David Goudie, Richard Roberts, Ingrid E. Scheffer, Carla Marini, Jayesh Patel, Samuel F. Berkovic, John C. Mulley, Ortrud K. Steinlein, and Daniel Bertrand

Human Nocturnal Frontal Lobe Epilepsy: Pharmocogenomic Profiles of Pathogenic Nicotinic Acetylcholine Receptor β-Subunit Mutations outside the Ion Channel Pore
Mol Pharmacol 2008 74: 379-391. Published online May 2, 2008; 10.1124/mol.107.044545 [Abstract] [Full Text] [PDF]  

Igor A. Schepetkin, Liliya N. Kirpotina, Jun Tian, Andrei I. Khlebnikov, Richard D. Ye, and Mark T. Quinn

Identification of Novel Formyl Peptide Receptor-Like 1 Agonists That Induce Macrophage Tumor Necrosis Factor Production
Mol Pharmacol 2008 74: 392-402. Published online May 5, 2008; 10.1124/mol.108.046946 [Abstract] [Full Text] [PDF] [Data Supplement]   

Eric S. Muise, Barbara Azzolina, David W. Kuo, Mohamed El-Sherbeini, Yejun Tan, Xiling Yuan, James Mu, John R. Thompson, Joel P. Berger, and Kenny K. Wong

Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor and Altered Metabolic States
Mol Pharmacol 2008 74: 403-412. Published online May 8, 2008; 10.1124/mol.108.044826 [Abstract] [Full Text] [PDF]  

Maoqing Dong, Polo C.-H. Lam, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan, and Laurence J. Miller

Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding
Mol Pharmacol 2008 74: 413-422. Published online May 8, 2008; 10.1124/mol.108.047209 [Abstract] [Full Text] [PDF]  

Alexander Stepanov, Karin C. Nitiss, Geoffrey Neale, and John L. Nitiss

Enhancing Drug Accumulation in Saccharomyces cerevisiae by Repression of Pleiotropic Drug Resistance Genes with Chimeric Transcription Repressors
Mol Pharmacol 2008 74: 423-431. Published online May 9, 2008; 10.1124/mol.107.044651 [Abstract] [Full Text] [PDF]  

Jun-ichi Koizumi, Takashi Kojima, Noriko Ogasawara, Ryuta Kamekura, Makoto Kurose, Mitsuru Go, Atsushi Harimaya, Masaki Murata, Makoto Osanai, Hideki Chiba, Tetsuo Himi, and Norimasa Sawada

Protein Kinase C Enhances Tight Junction Barrier Function of Human Nasal Epithelial Cells in Primary Culture by Transcriptional Regulation
Mol Pharmacol 2008 74: 432-442. Published online May 13, 2008; 10.1124/mol.107.043711 [Abstract] [Full Text] [PDF] [Data Supplement]   

Linhao Li, Tao Chen, Joseph D. Stanton, Tatsuya Sueyoshi, Masahiko Negishi, and Hongbing Wang

The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor
Mol Pharmacol 2008 74: 443-453. Published online May 20, 2008; 10.1124/mol.108.046656 [Abstract] [Full Text] [PDF]  

Marie L. Blanke and Antonius M. J. VanDongen

The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor
Mol Pharmacol 2008 74: 454-465. Published online May 15, 2008; 10.1124/mol.107.044115 [Abstract] [Full Text] [PDF]  

Tse-Yu Wu, Caleb M. Smith, Steven M. Sine, and Mark M. Levandoski

Morantel Allosterically Enhances Channel Gating of Neuronal Nicotinic Acetylcholine 3β2 Receptors
Mol Pharmacol 2008 74: 466-475. Published online May 5, 2008; 10.1124/mol.107.044388 [Abstract] [Full Text] [PDF]  

Chiara Riganti, Sophie Doublier, Costanzo Costamagna, Elisabetta Aldieri, Gianpiero Pescarmona, Dario Ghigo, and Amalia Bosia

Activation of Nuclear Factor-B Pathway by Simvastatin and RhoA Silencing Increases Doxorubicin Cytotoxicity in Human Colon Cancer HT29 Cells
Mol Pharmacol 2008 74: 476-484. Published online May 7, 2008; 10.1124/mol.108.045286 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mieke Gouwy, Sofie Struyf, Samuel Noppen, Evemie Schutyser, Jean-Yves Springael, Marc Parmentier, Paul Proost, and Jo Van Damme

Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events
Mol Pharmacol 2008 74: 485-495. Published online May 9, 2008; 10.1124/mol.108.045146 [Abstract] [Full Text] [PDF]  

Christine Börner, Jürgen Kraus, Andrea Bedini, Burkhart Schraven, and Volker Höllt

T-Cell Receptor/CD28-Mediated Activation of Human T Lymphocytes Induces Expression of Functional µ-Opioid Receptors
Mol Pharmacol 2008 74: 496-504. Published online May 7, 2008; 10.1124/mol.108.046029 [Abstract] [Full Text] [PDF]  

Ram N. Trivedi, Xiao-hong Wang, Elena Jelezcova, Eva M. Goellner, Jiang-bo Tang, and Robert W. Sobol

Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Mol Pharmacol 2008 74: 505-516. Published online May 13, 2008; 10.1124/mol.108.045112 [Abstract] [Full Text] [PDF]  

Li-Chen Ma, Ching-Chuan Kuo, Jin-Fen Liu, Li-Tzong Chen, and Jang-Yang Chang

Transcriptional Repression of O⁶-Methylguanine DNA Methyltransferase Gene Rendering Cells Hypersensitive to N,N'-Bis(2-chloroethyl)-N-nitrosurea in Camptothecin-Resistant Cells
Mol Pharmacol 2008 74: 517-526. Published online May 20, 2008; 10.1124/mol.107.043620 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kuicheon Choi, Elahe Mollapour, Jae H. Choi, and Stephen B. Shears

Cellular Energetic Status Supervises the Synthesis of Bis-Diphosphoinositol Tetrakisphosphate Independently of AMP-Activated Protein Kinase
Mol Pharmacol 2008 74: 527-536. Published online May 6, 2008; 10.1124/mol.107.044628 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21^WAF1/CIP1"
Mol Pharmacol 2008 74: 537. [Full Text] [PDF]  

Correction to "A Functional Steroid-Binding Element in an ATP-Binding Cassette Multidrug Transporter"
Mol Pharmacol 2008 74: 538. [Full Text] [PDF]  

Correction to "Stretch Induction of Cyclooxygenase-2 Expression in Human Urothelial Cells Is Calcium- and Protein Kinase C-Dependent"
Mol Pharmacol 2008 74: 539. [Full Text] [PDF]  

Correction to "Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8"
Mol Pharmacol 2008 74: 539. [Full Text] [PDF]  

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