Accelerated Communication:

Christine Graf, Martin Klumpp, Michael Habig, Philipp Rovina, Andreas Billich, Thomas Baumruker, Berndt Oberhauser, and Frédéric Bornancin

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor
Mol Pharmacol 2008 74: 925-932. Published online July 8, 2008; 10.1124/mol.108.048652 [Abstract] [Full Text] [PDF] [Data Supplement]   

Articles:

Masahiko Watabe and Toshio Nakaki

Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells
Mol Pharmacol 2008 74: 933-940. Published online July 3, 2008; 10.1124/mol.108.048546 [Abstract] [Full Text] [PDF]  

Jianliang Zhang, Fenqin Xue, and Yongchang Chang

Structural Determinants for Antagonist Pharmacology That Distinguish the ₁ GABA_C Receptor from GABA_A Receptors
Mol Pharmacol 2008 74: 941-951. Published online July 3, 2008; 10.1124/mol.108.048710 [Abstract] [Full Text] [PDF]  

Dana Schiefelbein, Oliver Seitz, Itamar Goren, Jan Philipp Dißmann, Helmut Schmidt, Malte Bachmann, Robert Sader, Gerd Geisslinger, Josef Pfeilschifter, and Stefan Frank

Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor- Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Skin Repair
Mol Pharmacol 2008 74: 952-963. Published online July 3, 2008; 10.1124/mol.108.049395 [Abstract] [Full Text] [PDF] [Data Supplement]   

Azza A. K. El-Sheikh, Jeroen J. M. W. van den Heuvel, Elmar Krieger, Frans G. M. Russel, and Jan B. Koenderink

Functional Role of Arginine 375 in Transmembrane Helix 6 of Multidrug Resistance Protein 4 (MRP4/ABCC4)
Mol Pharmacol 2008 74: 964-971. Published online July 8, 2008; 10.1124/mol.107.043661 [Abstract] [Full Text] [PDF]  

Seksiri Arttamangkul, Nidia Quillinan, Malcolm J. Low, Mark von Zastrow, John Pintar, and John T. Williams

Differential Activation and Trafficking of µ-Opioid Receptors in Brain Slices
Mol Pharmacol 2008 74: 972-979. Published online July 8, 2008; 10.1124/mol.108.048512 [Abstract] [Full Text] [PDF]  

Serge Guerreiro, Damien Toulorge, Etienne Hirsch, Marc Marien, Pierre Sokoloff, and Patrick P. Michel

Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels
Mol Pharmacol 2008 74: 980-989. Published online July 11, 2008; 10.1124/mol.108.048207 [Abstract] [Full Text] [PDF]  

Namandjé N. Bumpus and Paul F. Hollenberg

Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity
Mol Pharmacol 2008 74: 990-999. Published online July 11, 2008; 10.1124/mol.108.048637 [Abstract] [Full Text] [PDF]  

Mary L. García-Cazarín, Jennifer L. Smith, Daret K. St. Clair, and Michael T. Piascik

The _1D-Adrenergic Receptor Induces Vascular Smooth Muscle Apoptosis via a p53-Dependent Mechanism
Mol Pharmacol 2008 74: 1000-1007. Published online July 15, 2008; 10.1124/mol.108.047993 [Abstract] [Full Text] [PDF] [Data Supplement]   

Tau Benned-Jensen and Mette M. Rosenkilde

Structural Motifs of Importance for the Constitutive Activity of the Orphan 7TM Receptor EBI2: Analysis of Receptor Activation in the Absence of an Agonist
Mol Pharmacol 2008 74: 1008-1021. Published online July 15, 2008; 10.1124/mol.108.049676 [Abstract] [Full Text] [PDF] [Data Supplement]   

Christopher J. Clarke, J. Michael Guthrie, and Yusuf A. Hannun

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor- Involves Protein Kinase C- in Lung Epithelial Cells
Mol Pharmacol 2008 74: 1022-1032. Published online July 24, 2008; 10.1124/mol.108.046250 [Abstract] [Full Text] [PDF] [Data Supplement]   

Iva Bruhova, Denis B. Tikhonov, and Boris S. Zhorov

Access and Binding of Local Anesthetics in the Closed Sodium Channel
Mol Pharmacol 2008 74: 1033-1045. Published online July 24, 2008; 10.1124/mol.108.049759 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yi-Lin Chen, Min-Hui Jian, Chai-Ching Lin, Jung-Cheng Kang, Shee-Ping Chen, Po-Cheng Lin, Putzer-Joseph Hung, Jen-Ren Chen, Wen-Liang Chang, Shinn-Zong Lin, and Horng-Jyh Harn

The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy
Mol Pharmacol 2008 74: 1046-1058. Published online June 24, 2008; 10.1124/mol.107.044800 [Abstract] [Full Text] [PDF]  

Tao Qi, George Christopoulos, Richard J. Bailey, Arthur Christopoulos, Patrick M. Sexton, and Debbie L. Hay

Identification of N-Terminal Receptor Activity-Modifying Protein Residues Important for Calcitonin Gene-Related Peptide, Adrenomedullin, and Amylin Receptor Function
Mol Pharmacol 2008 74: 1059-1071. Published online July 1, 2008; 10.1124/mol.108.047142 [Abstract] [Full Text] [PDF] [Data Supplement]   

N. R. Khawaja, M. Carré, H. Kovacic, M. A. Estève, and D. Braguer

Patupilone-Induced Apoptosis Is Mediated by Mitochondrial Reactive Oxygen Species through Bim Relocalization to Mitochondria
Mol Pharmacol 2008 74: 1072-1083. Published online July 1, 2008; 10.1124/mol.108.048405 [Abstract] [Full Text] [PDF]  

Anja Verhulst, Rachel Sayer, Marc E. De Broe, Patrick C. D'Haese, and Colin D. A. Brown

Human Proximal Tubular Epithelium Actively Secretes but Does Not Retain Rosuvastatin
Mol Pharmacol 2008 74: 1084-1091. Published online July 8, 2008; 10.1124/mol.108.047647 [Abstract] [Full Text] [PDF]  

David Kowalski, Lakshmi Pendyala, Bertrand Daignan-Fornier, Stephen B. Howell, and Ruea-Yea Huang

Dysregulation of Purine Nucleotide Biosynthesis Pathways Modulates Cisplatin Cytotoxicity in Saccharomyces cerevisiae
Mol Pharmacol 2008 74: 1092-1100. Published online July 8, 2008; 10.1124/mol.108.048256 [Abstract] [Full Text] [PDF] [Data Supplement]   

Francesca Binda, Concetta Dipace, Erica Bowton, Sabrina D. Robertson, Brandon J. Lute, Jacob U. Fog, Minjia Zhang, Namita Sen, Roger J. Colbran, Margaret E. Gnegy, Ulrik Gether, Jonathan A. Javitch, Kevin Erreger, and Aurelio Galli

Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux
Mol Pharmacol 2008 74: 1101-1108. Published online July 10, 2008; 10.1124/mol.108.048447 [Abstract] [Full Text] [PDF]  

Natalia Fernandez, Federico Monczor, Alberto Baldi, Carlos Davio, and Carina Shayo

Histamine H2 Receptor Trafficking: Role of Arrestin, Dynamin, and Clathrin in Histamine H2 Receptor Internalization
Mol Pharmacol 2008 74: 1109-1118. Published online July 10, 2008; 10.1124/mol.108.045336 [Abstract] [Full Text] [PDF]  

Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E. Loiacono, Christian C. Felder, Blaine N. Armbruster, Bryan L. Roth, Patrick M. Sexton, and Arthur Christopoulos

New Insights into the Function of M₄ Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)
Mol Pharmacol 2008 74: 1119-1131. Published online July 15, 2008; 10.1124/mol.108.049353 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jun-Jie Yin, Fang Lao, Jie Meng, Peter P. Fu, Yuliang Zhao, Gengmei Xing, Xueyun Gao, Baoyun Sun, Paul C. Wang, Chunying Chen, and Xing-Jie Liang

Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger
Mol Pharmacol 2008 74: 1132-1140. Published online July 17, 2008; 10.1124/mol.108.048348 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yeung Ho, Ranmal Samarasinghe, Megan E. Knoch, Marcia Lewis, Elias Aizenman, and Donald B. DeFranco

Selective Inhibition of Mitogen-Activated Protein Kinase Phosphatases by Zinc Accounts for Extracellular Signal-Regulated Kinase 1/2-Dependent Oxidative Neuronal Cell Death
Mol Pharmacol 2008 74: 1141-1151. Published online July 17, 2008; 10.1124/mol.108.049064 [Abstract] [Full Text] [PDF]  

Verawan Uchaipichat, Aleksandra Galetin, J. Brian Houston, Peter I. Mackenzie, J. Andrew Williams, and John O. Miners

Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites
Mol Pharmacol 2008 74: 1152-1162. Published online July 22, 2008; 10.1124/mol.108.048645 [Abstract] [Full Text] [PDF]  

Yihong Zhang, Naushaba Nayeem, and Tim Green

Mutations to the Kainate Receptor Subunit GluR6 Binding Pocket That Selectively Affect Domoate Binding
Mol Pharmacol 2008 74: 1163-1169. Published online July 29, 2008; 10.1124/mol.108.048819 [Abstract] [Full Text] [PDF] [Data Supplement]   

Errata:

Correction to "Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase"
Mol Pharmacol 2008 74: 1170. [Full Text] [PDF]  

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