Minireview:

Alexander R. Mackie and Kenneth L. Byron

Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention
Mol Pharmacol 2008 74: 1171-1179. Published online August 6, 2008; 10.1124/mol.108.049825 [Abstract] [Full Text] [PDF]  

Perspective:

Neil Harrison and Carla Nau

Sensitization of Nociceptive Ion Channels by Inhaled Anesthetics—A Pain in the Gas?
Mol Pharmacol 2008 74: 1180-1182. Published online September 3, 2008; 10.1124/mol.108.051615 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Wassana Wijagkanalan, Yuriko Higuchi, Shigeru Kawakami, Mugen Teshima, Hitoshi Sasaki, and Mitsuru Hashida

Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model
Mol Pharmacol 2008 74: 1183-1192. Published online July 30, 2008; 10.1124/mol.108.050153 [Abstract] [Full Text] [PDF]  

David J. Nicholls, Nick P. Tomkinson, Katherine E. Wiley, Anne Brammall, Lorna Bowers, Caroline Grahames, Alasdair Gaw, Premji Meghani, Philip Shelton, Tracey J. Wright, and Philip R. Mallinder

Identification of a Putative Intracellular Allosteric Antagonist Binding-Site in the CXC Chemokine Receptors 1 and 2
Mol Pharmacol 2008 74: 1193-1202. Published online August 1, 2008; 10.1124/mol.107.044610 [Abstract] [Full Text] [PDF] [Data Supplement]   

Angelika Klose, Tobias Huth, and Christian Alzheimer

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion
Mol Pharmacol 2008 74: 1203-1214. Published online August 5, 2008; 10.1124/mol.108.047837 [Abstract] [Full Text] [PDF]  

Myong-Hee Sung, Lorena Bagain, Zhong Chen, Tatiana Karpova, Xinping Yang, Christopher Silvin, Ty C. Voss, James G. McNally, Carter Van Waes, and Gordon L. Hager

Dynamic Effect of Bortezomib on Nuclear Factor-B Activity and Gene Expression in Tumor Cells
Mol Pharmacol 2008 74: 1215-1222. Published online August 6, 2008; 10.1124/mol.108.049114 [Abstract] [Full Text] [PDF] [Data Supplement]   

Xing Yin, Bo Li, Hungdar Chen, and Kevin J. Catt

Differential Signaling Pathways in Angiotensin II- and Epidermal Growth Factor-stimulated Hepatic C9 Cells
Mol Pharmacol 2008 74: 1223-1233. Published online August 7, 2008; 10.1124/mol.108.048504 [Abstract] [Full Text] [PDF]  

Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio, and Maria R. Ciriolo

Reactive Oxygen Species Mediate p53 Activation and Apoptosis Induced by Sodium Nitroprusside in SH-SY5Y Cells
Mol Pharmacol 2008 74: 1234-1245. Published online August 1, 2008; 10.1124/mol.108.048975 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jillian G. Baker, Richard G. W. Proudman, Nicola C. Hawley, Peter M. Fischer, and Stephen J. Hill

Role of Key Transmembrane Residues in Agonist and Antagonist Actions at the Two Conformations of the Human β1-Adrenoceptor
Mol Pharmacol 2008 74: 1246-1260. Published online August 7, 2008; 10.1124/mol.108.048371 [Abstract] [Full Text] [PDF] [Data Supplement]   

Paul M. Cornett, José A. Matta, and Gerard P. Ahern

General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1
Mol Pharmacol 2008 74: 1261-1268. Published online August 8, 2008; 10.1124/mol.108.049684 [Abstract] [Full Text] [PDF]  

Markus Rieck, Wolfgang Meissner, Simone Ries, Sabine Müller-Brüsselbach, and Rolf Müller

Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR) β/: A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid
Mol Pharmacol 2008 74: 1269-1277. Published online August 13, 2008; 10.1124/mol.108.050625 [Abstract] [Full Text] [PDF]  

Juan F. Lopez-Gimenez, M. Teresa Vilaró, and Graeme Milligan

Morphine Desensitization, Internalization, and Down-Regulation of the µ Opioid Receptor Is Facilitated by Serotonin 5-Hydroxytryptamine_2A Receptor Coactivation
Mol Pharmacol 2008 74: 1278-1291. Published online August 14, 2008; 10.1124/mol.108.048272 [Abstract] [Full Text] [PDF] [Data Supplement]   

Amit Roy, Agneyo Ganguly, Somdeb BoseDasgupta, Benu Brata Das, Churala Pal, Parasuraman Jaisankar, and Hemanta K. Majumder

Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3'-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani
Mol Pharmacol 2008 74: 1292-1307. Published online August 14, 2008; 10.1124/mol.108.050161 [Abstract] [Full Text] [PDF] [Data Supplement]   

Pedro J. Gonzalez-Cabrera, Euijung Jo, M. Germana Sanna, Steven Brown, Nora Leaf, David Marsolais, Marie-Therese Schaeffer, Jacqueline Chapman, Michael Cameron, Miguel Guerrero, Edward Roberts, and Hugh Rosen

Full Pharmacological Efficacy of a Novel S1P₁ Agonist That Does Not Require S1P-Like Headgroup Interactions
Mol Pharmacol 2008 74: 1308-1318. Published online August 15, 2008; 10.1124/mol.108.049783 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ling-Chang Kung, Samuel H. H. Chan, Kay L. H. Wu, Chen-Chun Ou, Ming-Hon Tai, and Julie Y. H. Chan

Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene
Mol Pharmacol 2008 74: 1319-1332. Published online August 20, 2008; 10.1124/mol.108.048793 [Abstract] [Full Text] [PDF] [Data Supplement]   

Adam Wheeler, Chuan Wang, Ke Yang, Kun Fang, Kevin Davis, Amanda M. Styer, Uyenlinh Mirshahi, Christophe Moreau, Jean Revilloud, Michel Vivaudou, Shunhe Liu, Tooraj Mirshahi, and Kim W. Chan

Coassembly of Different Sulfonylurea Receptor Subtypes Extends the Phenotypic Diversity of ATP-sensitive Potassium (K_ATP) Channels
Mol Pharmacol 2008 74: 1333-1344. Published online August 22, 2008; 10.1124/mol.108.048355 [Abstract] [Full Text] [PDF] [Data Supplement]   

Colleen M. Niswender, Kari A. Johnson, C. David Weaver, Carrie K. Jones, Zixiu Xiang, Qingwei Luo, Alice L. Rodriguez, Joy E. Marlo, Tomas de Paulis, Analisa D. Thompson, Emily L. Days, Tasha Nalywajko, Cheryl A. Austin, Michael Baxter Williams, Jennifer E. Ayala, Richard Williams, Craig W. Lindsley, and P. Jeffrey Conn

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Mol Pharmacol 2008 74: 1345-1358. Published online July 29, 2008; 10.1124/mol.108.049551 [Abstract] [Full Text] [PDF] [Data Supplement]   

Carine Chavey, Marcus Mühlbauer, Carine Bossard, Ariane Freund, Sébastien Durand, Christian Jorgensen, Christian Jobin, and Gwendal Lazennec

Interleukin-8 Expression Is Regulated by Histone Deacetylases through the Nuclear Factor-B Pathway in Breast Cancer
Mol Pharmacol 2008 74: 1359-1366. Published online July 30, 2008; 10.1124/mol.108.047332 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bernice C. Lin, Linh P. Nguyen, Jacqueline A. Walisser, and Christopher A. Bradfield

A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse
Mol Pharmacol 2008 74: 1367-1371. Published online July 31, 2008; 10.1124/mol.108.047068 [Abstract] [Full Text] [PDF]  

Robert J. Paproski, Amy M. L. Ng, Sylvia Y. M. Yao, Kathryn Graham, James D. Young, and Carol E. Cass

The Role of Human Nucleoside Transporters in Uptake of 3'-Deoxy-3'-fluorothymidine
Mol Pharmacol 2008 74: 1372-1380. Published online July 31, 2008; 10.1124/mol.108.048900 [Abstract] [Full Text] [PDF]  

Ghenet K. Hagos, Samer O. Abdul-Hay, Johann Sohn, Praneeth D. Edirisinghe, R. Esala P. Chandrasena, Zhiqiang Wang, Qian Li, and Gregory R. J. Thatcher

Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention
Mol Pharmacol 2008 74: 1381-1391. Published online August 1, 2008; 10.1124/mol.108.046664 [Abstract] [Full Text] [PDF] [Data Supplement]   

Benjamin K. Lau and Christopher W. Vaughan

Muscarinic Modulation of Synaptic Transmission via Endocannabinoid Signalling in the Rat Midbrain Periaqueductal Gray
Mol Pharmacol 2008 74: 1392-1398. Published online August 4, 2008; 10.1124/mol.108.045872 [Abstract] [Full Text] [PDF]  

Jun-Yang Liou, Chia-Ching Wu, Bo-Rui Chen, Linju B. Yen, and Kenneth K. Wu

Nonsteroidal Anti-Inflammatory Drugs Induced Endothelial Apoptosis by Perturbing Peroxisome Proliferator-Activated Receptor- Transcriptional Pathway
Mol Pharmacol 2008 74: 1399-1406. Published online August 4, 2008; 10.1124/mol.108.049569 [Abstract] [Full Text] [PDF]  

Daniel Bertrand, Sonia Bertrand, Steven Cassar, Earl Gubbins, Jinhe Li, and M. Gopalakrishnan

Positive Allosteric Modulation of the 7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment
Mol Pharmacol 2008 74: 1407-1416. Published online August 4, 2008; 10.1124/mol.107.042820 [Abstract] [Full Text] [PDF]  

Masaaki Sato, Dana S. Hutchinson, Bronwyn A. Evans, and Roger J. Summers

The β₃-Adrenoceptor Agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and Antagonist (S)-N-[4-[2-[[3-[3-(Acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) Activate Different Signaling Pathways in Chinese Hamster Ovary-K1 Cells Stably Expressing the Human β₃-Adrenoceptor
Mol Pharmacol 2008 74: 1417-1428. Published online August 6, 2008; 10.1124/mol.108.046979 [Abstract] [Full Text] [PDF]  

Michael G. Borland, Jennifer E. Foreman, Elizabeth E. Girroir, Reza Zolfaghari, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, A. Catharine Ross, and Jeffrey M. Peters

Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/ Inhibits Cell Proliferation in Human HaCaT Keratinocytes
Mol Pharmacol 2008 74: 1429-1442. Published online August 7, 2008; 10.1124/mol.108.050609 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mark J. Perrin, Philip W. Kuchel, Terence J. Campbell, and Jamie I. Vandenberg

Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-à-go-go-Related Gene Channels
Mol Pharmacol 2008 74: 1443-1452. Published online August 13, 2008; 10.1124/mol.108.049056 [Abstract] [Full Text] [PDF] [Data Supplement]   

Vania De Arcangelis, Dagoberto Soto, and Yang Xiang

Phosphodiesterase 4 and Phosphatase 2A Differentially Regulate cAMP/Protein Kinase A Signaling for Cardiac Myocyte Contraction under Stimulation of β₁ Adrenergic Receptor
Mol Pharmacol 2008 74: 1453-1462. Published online August 14, 2008; 10.1124/mol.108.049718 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bruno P. Guiard, Mostafa El Mansari, and Pierre Blier

Cross-Talk between Dopaminergic and Noradrenergic Systems in the Rat Ventral Tegmental Area, Locus Ceruleus, and Dorsal Hippocampus
Mol Pharmacol 2008 74: 1463-1475. Published online August 14, 2008; 10.1124/mol.108.048033 [Abstract] [Full Text] [PDF]  

William A. Schmalhofer, Jeffrey Calhoun, Rachel Burrows, Timothy Bailey, Martin G. Kohler, Adam B. Weinglass, Gregory J. Kaczorowski, Maria L. Garcia, Martin Koltzenburg, and Birgit T. Priest

ProTx-II, a Selective Inhibitor of Na_V1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
Mol Pharmacol 2008 74: 1476-1484. Published online August 26, 2008; 10.1124/mol.108.047670 [Abstract] [Full Text] [PDF]  

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