Minireview:

Debarshi Mustafi and Krzysztof Palczewski

Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins, Adrenergic and Adenosine Receptors
Mol Pharmacol 2009 75: 1-12. Published online October 22, 2008; 10.1124/mol.108.051938 [Abstract] [Full Text] [PDF]  

Perspective:

Roland Seifert and Stefan Dove

Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities
Mol Pharmacol 2009 75: 13-18. Published online November 10, 2008; 10.1124/mol.108.052944 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Hongxiang Lan, Martha M. Teeter, Vsevolod V. Gurevich, and Kim A. Neve

An Intracellular Loop 2 Amino Acid Residue Determines Differential Binding of Arrestin to the Dopamine D₂ and D₃ Receptors
Mol Pharmacol 2009 75: 19-26. Published online September 26, 2008; 10.1124/mol.108.050542 [Abstract] [Full Text] [PDF]  

Li-Fang Hu, Ming Lu, Zhi-Yuan Wu, Peter T.-H. Wong, and Jin-Song Bian

Hydrogen Sulfide Inhibits Rotenone-Induced Apoptosis via Preservation of Mitochondrial Function
Mol Pharmacol 2009 75: 27-34. Published online October 2, 2008; 10.1124/mol.108.047985 [Abstract] [Full Text] [PDF]  

David. L. Carbone, Katriana A. Popichak, Julie A. Moreno, Stephen Safe, and Ronald B. Tjalkens

Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis
Mol Pharmacol 2009 75: 35-43. Published online October 7, 2008; 10.1124/mol.108.050781 [Abstract] [Full Text] [PDF] [Data Supplement]   

Birgitte Holst, Thomas M. Frimurer, Jacek Mokrosinski, Tine Halkjaer, Karina B. Cullberg, Christina R. Underwood, and Thue W. Schwartz

Overlapping Binding Site for the Endogenous Agonist, Small-Molecule Agonists, and Ago-allosteric Modulators on the Ghrelin Receptor
Mol Pharmacol 2009 75: 44-59. Published online October 15, 2008; 10.1124/mol.108.049189 [Abstract] [Full Text] [PDF]  

Laetitia Mony, Lucie Krzaczkowski, Manuel Leonetti, Anne Le Goff, Karine Alarcon, Jacques Neyton, Hughes-Olivier Bertrand, Francine Acher, and Pierre Paoletti

Structural Basis of NR2B-Selective Antagonist Recognition by N-Methyl-D-aspartate Receptors
Mol Pharmacol 2009 75: 60-74. Published online October 15, 2008; 10.1124/mol.108.050971 [Abstract] [Full Text] [PDF] [Data Supplement]   

Akiko Fujita, Tomoyuki Shishido, Yunfeng Yuan, Eiji Inamoto, Shuh Narumiya, and Naoki Watanabe

Imatinib Mesylate (STI571)-Induced Cell Edge Translocation of Kinase-Active and Kinase-Defective Abelson Kinase: Requirements of Myristoylation and src Homology 3 Domain
Mol Pharmacol 2009 75: 75-84. Published online October 3, 2008; 10.1124/mol.108.051706 [Abstract] [Full Text] [PDF] [Data Supplement]   

Takafumi Hara, Akira Hirasawa, Qi Sun, Taka-aki Koshimizu, Chisato Itsubo, Keiko Sadakane, Takeo Awaji, and Gozoh Tsujimoto

Flow Cytometry-Based Binding Assay for GPR40 (FFAR1; Free Fatty Acid Receptor 1)
Mol Pharmacol 2009 75: 85-91. Published online October 16, 2008; 10.1124/mol.108.052225 [Abstract] [Full Text] [PDF]  

Marcos M. Pires, Dana Emmert, Christine A. Hrycyna, and Jean Chmielewski

Inhibition of P-Glycoprotein-Mediated Paclitaxel Resistance by Reversibly Linked Quinine Homodimers
Mol Pharmacol 2009 75: 92-100. Published online October 22, 2008; 10.1124/mol.108.050492 [Abstract] [Full Text] [PDF]  

Ying-Mei Lu, Feng Han, Norifumi Shioda, Shigeki Moriguchi, Yasufumi Shirasaki, Zheng-Hong Qin, and Kohji Fukunaga

Phenylephrine-Induced Cardiomyocyte Injury Is Triggered by Superoxide Generation through Uncoupled Endothelial Nitric-Oxide Synthase and Ameliorated by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a Novel Calmodulin Antagonist
Mol Pharmacol 2009 75: 101-112. Published online October 24, 2008; 10.1124/mol.108.050716 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hongxiang Lan, Yong Liu, Michal I. Bell, Vsevolod V. Gurevich, and Kim A. Neve

A Dopamine D₂ Receptor Mutant Capable of G Protein-Mediated Signaling but Deficient in Arrestin Binding
Mol Pharmacol 2009 75: 113-123. Published online September 22, 2008; 10.1124/mol.108.050534 [Abstract] [Full Text] [PDF] [Erratum]   

Archie N. Tse, Tahir N. Sheikh, Ho Alan, Ting-Chao Chou, and Gary K. Schwartz

90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G₂/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1
Mol Pharmacol 2009 75: 124-133. Published online September 26, 2008; 10.1124/mol.108.050807 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lukmanee Tradtrantip, Buranee Yangthara, Prashant Padmawar, Christopher Morrison, and A. S. Verkman

Thiophenecarboxylate Suppressor of Cyclic Nucleotides Discovered in a Small-Molecule Screen Blocks Toxin-Induced Intestinal Fluid Secretion
Mol Pharmacol 2009 75: 134-142. Published online September 29, 2008; 10.1124/mol.108.050567 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hisamitsu Hayashi and Yuichi Sugiyama

Short-Chain Ubiquitination Is Associated with the Degradation Rate of a Cell-Surface-Resident Bile Salt Export Pump (BSEP/ABCB11)
Mol Pharmacol 2009 75: 143-150. Published online October 1, 2008; 10.1124/mol.108.049288 [Abstract] [Full Text] [PDF]  

Ji-An Liang, Shih-Lu Wu, Hsin-Yi Lo, Chien-Yun Hsiang, and Tin-Yun Ho

Vanillin Inhibits Matrix Metalloproteinase-9 Expression through Down-Regulation of Nuclear Factor-B Signaling Pathway in Human Hepatocellular Carcinoma Cells
Mol Pharmacol 2009 75: 151-157. Published online October 3, 2008; 10.1124/mol.108.049502 [Abstract] [Full Text] [PDF] [Data Supplement]   

Anthony Yiu-Ho Woo, Tian-Bing Wang, Xiaokun Zeng, Weizhong Zhu, Darrell R. Abernethy, Irving W. Wainer, and Rui-Ping Xiao

Stereochemistry of an Agonist Determines Coupling Preference of β₂-Adrenoceptor to Different G Proteins in Cardiomyocytes
Mol Pharmacol 2009 75: 158-165. Published online October 7, 2008; 10.1124/mol.108.051078 [Abstract] [Full Text] [PDF] [Data Supplement]   

Man Liu and James P. Dilger

Site Selectivity of Competitive Antagonists for the Mouse Adult Muscle Nicotinic Acetylcholine Receptor
Mol Pharmacol 2009 75: 166-173. Published online October 8, 2008; 10.1124/mol.108.051060 [Abstract] [Full Text] [PDF]  

Wenke Feng, Fei Ye, Wanli Xue, Zhanxiang Zhou, and Y. James Kang

Copper Regulation of Hypoxia-Inducible Factor-1 Activity
Mol Pharmacol 2009 75: 174-182. Published online October 8, 2008; 10.1124/mol.108.051516 [Abstract] [Full Text] [PDF]  

Nagesh Chopra, Derek Laver, Sean S. Davies, and Björn C. Knollmann

Amitriptyline Activates Cardiac Ryanodine Channels and Causes Spontaneous Sarcoplasmic Reticulum Calcium Release
Mol Pharmacol 2009 75: 183-195. Published online October 9, 2008; 10.1124/mol.108.051490 [Abstract] [Full Text] [PDF]  

Lindsay Marek, Kathryn E. Ware, Alexa Fritzsche, Paula Hercule, Wallace R. Helton, Jennifer E. Smith, Lee A. McDermott, Christopher D. Coldren, Raphael A. Nemenoff, Daniel T. Merrick, Barbara A. Helfrich, Paul A. Bunn, Jr., and Lynn E. Heasley

Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells
Mol Pharmacol 2009 75: 196-207. Published online October 10, 2008; 10.1124/mol.108.049544 [Abstract] [Full Text] [PDF]  

Xiao-ming Liu, Kelly J. Peyton, Natalia N. Mendelev, Hong Wang, David A. Tulis, and William Durante

YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells
Mol Pharmacol 2009 75: 208-217. Published online October 15, 2008; 10.1124/mol.108.048314 [Abstract] [Full Text] [PDF]  

Ruoli Bai, Michael C. Edler, Peter L. Bonate, Terry D. Copeland, George R. Pettit, Richard F. Ludueña, and Ernest Hamel

Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity
Mol Pharmacol 2009 75: 218-226. Published online October 16, 2008; 10.1124/mol.108.051110 [Abstract] [Full Text] [PDF]  

Emily J. Welch, Ram P. Naikawadi, Zhenyu Li, Phoebe Lin, Satoshi Ishii, Takao Shimizu, Chinnaswamy Tiruppathi, Xiaoping Du, Papasani V. Subbaiah, and Richard D. Ye

Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation
Mol Pharmacol 2009 75: 227-234. Published online October 17, 2008; 10.1124/mol.108.051003 [Abstract] [Full Text] [PDF] [Data Supplement]   

Li Zhang, Lawrence F. Brass, and David R. Manning

The G_q and G₁₂ Families of Heterotrimeric G Proteins Report Functional Selectivity
Mol Pharmacol 2009 75: 235-241. Published online October 24, 2008; 10.1124/mol.108.050906 [Abstract] [Full Text] [PDF]  

Sang Mi Shin and Sang Geon Kim

Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
Mol Pharmacol 2009 75: 242-253. Published online October 22, 2008; 10.1124/mol.108.051128 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor"
Mol Pharmacol 2009 75: 254-257. [Full Text] [PDF]  

Correction to "Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites"
Mol Pharmacol 2009 75: 258. [Full Text] [PDF]  

Correction to Table of Contents (Volume 74, Number 6, December 2008)
Mol Pharmacol 2009 75: 258. [Full Text] [PDF]  

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