Mol Pharm -- Table of Contents (74 [1])

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July 2008; 74 (1)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Accelerated Communication:

Robert Fürst, Martin F. Bubik, Peter Bihari, Bettina A. Mayer, Alexander G. Khandoga, Florian Hoffmann, Markus Rehberg, Fritz Krombach, Stefan Zahler, and Angelika M. Vollmar: Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo
Mol Pharmacol 2008 74: 1-8. Published online April 15, 2008; 10.1124/mol.108.045773 [Abstract] [Full Text] [PDF] [Data Supplement]

Articles:

Paul E. Bandler, Christopher J. Westlake, Caroline E. Grant, Susan P. C. Cole, and Roger G. Deeley: Identification of Regions Required for Apical Membrane Localization of Human Multidrug Resistance Protein 2
Mol Pharmacol 2008 74: 9-19. Published online April 1, 2008; 10.1124/mol.108.045674 [Abstract] [Full Text] [PDF]

Venkatesh L. Hegde, Shweta Hegde, Benjamin F. Cravatt, Lorne J. Hofseth, Mitzi Nagarkatti, and Prakash S. Nagarkatti: Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells
Mol Pharmacol 2008 74: 20-33. Published online April 3, 2008; 10.1124/mol.108.047035 [Abstract] [Full Text] [PDF]

Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith, III, and Scott L. Diamond: Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L
Mol Pharmacol 2008 74: 34-41. Published online April 10, 2008; 10.1124/mol.108.046219 [Abstract] [Full Text] [PDF]

Kazuya Narushima, Tappei Takada, Yoshihide Yamanashi, and Hiroshi Suzuki: Niemann-Pick C1-Like 1 Mediates ${alpha}$ -Tocopherol Transport
Mol Pharmacol 2008 74: 42-49. Published online April 10, 2008; 10.1124/mol.107.043034 [Abstract] [Full Text] [PDF]

Domenico Tricarico, Antonietta Mele, Giulia Maria Camerino, Antonio Laghezza, Giuseppe Carbonara, Giuseppe Fracchiolla, Paolo Tortorella, Fulvio Loiodice, and Diana Conte Camerino: Molecular Determinants for the Activating/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle K_ATP Channels
Mol Pharmacol 2008 74: 50-58. Published online April 10, 2008; 10.1124/mol.108.046615 [Abstract] [Full Text] [PDF]

Chiara Fiorentini, Chiara Busi, Emanuela Gorruso, Cecilia Gotti, PierFranco Spano, and Cristina Missale: Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization
Mol Pharmacol 2008 74: 59-69. Published online April 18, 2008; 10.1124/mol.107.043885 [Abstract] [Full Text] [PDF]

Hyunju Cho, Ho-Youl Lee, Dae-Ro Ahn, Sang Yoon Kim, Sunyun Kim, Keun Byeol Lee, You Mie Lee, Hyunsung Park, and Eun Gyeong Yang: Baicalein Induces Functional Hypoxia-Inducible Factor-1 ${alpha}$ and Angiogenesis
Mol Pharmacol 2008 74: 70-81. Published online April 21, 2008; 10.1124/mol.107.040162 [Abstract] [Full Text] [PDF] [Data Supplement]

Takahiro Yamauchi, Masami Ogawa, and Takanori Ueda: Carmustine-Resistant Cancer Cells Are Sensitized to Temozolomide As A Result of Enhanced Mismatch Repair during the Development of Carmustine Resistance
Mol Pharmacol 2008 74: 82-91. Published online April 22, 2008; 10.1124/mol.107.041988 [Abstract] [Full Text] [PDF] [Supplemental Data]

Gabriel Birkus, Nilima Kutty, Gong-Xin He, Andrew Mulato, William Lee, Martin McDermott, and Tomas Cihlar: Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and Other Tenofovir Phosphonoamidate Prodrugs by Human Proteases
Mol Pharmacol 2008 74: 92-100. Published online April 22, 2008; 10.1124/mol.108.045526 [Abstract] [Full Text] [PDF]

Matthew J. McFarland, Tamera K. Bardell, Marla L. Yates, Ekaterina A. Placzek, and Eric L. Barker: RNA Interference-Mediated Knockdown of Dynamin 2 Reduces Endocannabinoid Uptake into Neuronal dCAD Cells
Mol Pharmacol 2008 74: 101-108. Published online April 24, 2008; 10.1124/mol.108.044834 [Abstract] [Full Text] [PDF]

Tamsin M. Lindström, Aarthi R. Mohan, Mark R. Johnson, and Phillip R. Bennett: Histone Deacetylase Inhibitors Exert Time-Dependent Effects on Nuclear Factor- ${kappa}$ B but Consistently Suppress the Expression of Proinflammatory Genes in Human Myometrial Cells
Mol Pharmacol 2008 74: 109-121. Published online March 28, 2008; 10.1124/mol.107.042838 [Abstract] [Full Text] [PDF]

Adam L. VanWert, Chutima Srimaroeng, and Douglas H. Sweet: Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin
Mol Pharmacol 2008 74: 122-131. Published online April 1, 2008; 10.1124/mol.107.042853 [Abstract] [Full Text] [PDF]

Alexandre Kuryatov, Jennifer Onksen, and Jon Lindstrom: Roles of Accessory Subunits in ${alpha}$ 4β2^* Nicotinic Receptors
Mol Pharmacol 2008 74: 132-143. Published online April 1, 2008; 10.1124/mol.108.046789 [Abstract] [Full Text] [PDF]

N. Ferri, A. Granata, C. Pirola, F. Torti, P. J. Pfister, R. Dorent, and A. Corsini: Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27^Kip1/Cyclin E Expression
Mol Pharmacol 2008 74: 144-153. Published online April 15, 2008; 10.1124/mol.108.046045 [Abstract] [Full Text] [PDF]

Rodrigo Medeiros, Gustavo Büchele Rodrigues, Cláudia Pinto Figueiredo, Eduardo Büchele Rodrigues, Astor Grumman, Jr., Octavio Menezes-de-Lima, Jr., Giselle Fazzioni Passos, and João Batista Calixto: Molecular Mechanisms of Topical Anti-Inflammatory Effects of Lipoxin A₄ in Endotoxin-Induced Uveitis
Mol Pharmacol 2008 74: 154-161. Published online April 15, 2008; 10.1124/mol.108.046870 [Abstract] [Full Text] [PDF] [Data Supplement]

Ségolène Galandrin, Geneviève Oligny-Longpré, Hélène Bonin, Koji Ogawa, Céline Galés, and Michel Bouvier: Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the β1-Adrenergic Receptor
Mol Pharmacol 2008 74: 162-172. Published online April 10, 2008; 10.1124/mol.107.043893 [Abstract] [Full Text] [PDF]

Simona Caporali, Lauretta Levati, Giuseppe Starace, Gianluca Ragone, Enzo Bonmassar, Ester Alvino, and Stefania D'Atri: AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition
Mol Pharmacol 2008 74: 173-183. Published online April 15, 2008; 10.1124/mol.107.044743 [Abstract] [Full Text] [PDF]

Benny J. Evison, Francis Chiu, Gabriella Pezzoni, Don R. Phillips, and Suzanne M. Cutts: Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets
Mol Pharmacol 2008 74: 184-194. Published online April 15, 2008; 10.1124/mol.108.045625 [Abstract] [Full Text] [PDF]

Brian W. Jones and Patricia M. Hinkle: Arrestin Binds to Different Phosphorylated Regions of the Thyrotropin-Releasing Hormone Receptor with Distinct Functional Consequences
Mol Pharmacol 2008 74: 195-202. Published online April 15, 2008; 10.1124/mol.108.045948 [Abstract] [Full Text] [PDF]

L. M. Sharkey and C. Czajkowski: Individually Monitoring Ligand-Induced Changes in the Structure of the GABA_A Receptor at Benzodiazepine Binding Site and Non-Binding-Site Interfaces
Mol Pharmacol 2008 74: 203-212. Published online April 18, 2008; 10.1124/mol.108.044891 [Abstract] [Full Text] [PDF]

Neta Rimmerman, Heather B. Bradshaw, H. Velocity Hughes, Jay Shih-Chieh Chen, Sherry Shu-Jung Hu, Douglas McHugh, Eivind Vefring, Jan A. Jahnsen, Eric L. Thompson, Kim Masuda, Benjamin F. Cravatt, Sumner Burstein, Michael R. Vasko, Anne L. Prieto, David K. O'Dell, and J. Michael Walker: N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons
Mol Pharmacol 2008 74: 213-224. Published online April 18, 2008; 10.1124/mol.108.045997 [Abstract] [Full Text] [PDF] [Data Supplement]

C. K. Lim, D. S. Kalinowski, and D. R. Richardson: Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class
Mol Pharmacol 2008 74: 225-235. Published online April 18, 2008; 10.1124/mol.108.046847 [Abstract] [Full Text] [PDF]

Young-Kwon Park, Dae-Ro Ahn, Myoungsuk Oh, Taekyoung Lee, Eun Gyeong Yang, Miwon Son, and Hyunsung Park: Nitric Oxide Donor, (±)-S-Nitroso-N-acetylpenicillamine, Stabilizes Transactive Hypoxia-Inducible Factor-1 ${alpha}$ by Inhibiting von Hippel-Lindau Recruitment and Asparagine Hydroxylation
Mol Pharmacol 2008 74: 236-245. Published online April 21, 2008; 10.1124/mol.108.045278 [Abstract] [Full Text] [PDF] [Data Supplement]

Irina A. Vasilevskaya, Muthu Selvakumaran, and Peter J. O'Dwyer: Disruption of Signaling through SEK1 and MKK7 Yields Differential Responses in Hypoxic Colon Cancer Cells Treated with Oxaliplatin
Mol Pharmacol 2008 74: 246-254. Published online April 24, 2008; 10.1124/mol.107.044644 [Abstract] [Full Text] [PDF]

Bin Dong and Fumio Matsumura: Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin through a Nongenomic Pathway in MCF10A Cells
Mol Pharmacol 2008 74: 255-263. Published online April 3, 2008; 10.1124/mol.107.044669 [Abstract] [Full Text] [PDF]

Kevin R. Robillard, Derek B.J. Bone, Jamie S. Park, and James R. Hammond: Characterization of mENT1 ${Delta}$ 11, a Novel Alternative Splice Variant of the Mouse Equilibrative Nucleoside Transporter 1
Mol Pharmacol 2008 74: 264-273. Published online April 15, 2008; 10.1124/mol.107.041871 [Abstract] [Full Text] [PDF]

Shurong Huang, Ling Zhao, Kihoon Kim, Dong Seok Lee, and Daniel H. Hwang: Inhibition of Nod2 Signaling and Target Gene Expression by Curcumin
Mol Pharmacol 2008 74: 274-281. Published online April 15, 2008; 10.1124/mol.108.046169 [Abstract] [Full Text] [PDF]

Marie-Claude Lauzier, Geneviève A. Robitaille, Denise A. Chan, Amato J. Giaccia, and Darren E. Richard: (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors
Mol Pharmacol 2008 74: 282-288. Published online April 18, 2008; 10.1124/mol.108.045690 [Abstract] [Full Text] [PDF]

Vidula Dixit and Rudy L. Juliano: Selective Killing of Smad4-Negative Tumor Cells via a Designed Repressor Strategy
Mol Pharmacol 2008 74: 289-297. Published online April 21, 2008; 10.1124/mol.108.046953 [Abstract] [Full Text] [PDF]

Anamaria Brozovic, Dragomira Majhen, Vibor Roje, Nevenka Mikac, Sanjica Jakopec, Gerhard Fritz, Maja Osmak, and Andreja Ambriovic-Ristov: ${alpha}$ _vβ₃ Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species
Mol Pharmacol 2008 74: 298-306. Published online April 25, 2008; 10.1124/mol.107.043836 [Abstract] [Full Text] [PDF]

Errata:

: Correction to Table of Contents (Volume 73, Number 6, June 2008)
Mol Pharmacol 2008 74: 307. [Full Text] [PDF]

Cover Caption:

About the cover: Overlay of papain/CLIK-148 (light green) with computational model of SID 26681509 in papain (tan). See the article by Shah et al. on 34 of this issue.