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Future Table of Contents: September 2008; 74 (3)

PERSPECTIVE

ACCELERATED COMMUNICATION

ARTICLE

PERSPECTIVE

Terry P Kenakin

Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein:De-emphasizing the Geography of Binding (Relates to article by Redka et al.) (Fast Forward 26 June 2008)

ACCELERATED COMMUNICATION

Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng Hu, and Val J. Watts

Ligand-Dependant Oligomerization of Dopamine D2 and Adenosine A2A Receptors in Living Neuronal Cells. (Fast Forward 4 June 2008)

ARTICLE

Im-Sook Song, Helen H. W. Chen, Isamu Aiba, Anwar Hossain, Zheng D. Liang, Leo Klomp, and Macus Tien Kuo

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells (Fast Forward 15 May 2008)

Huixia Zhang, Xiaohui Wu, Honggang Wang, Andrei M. Mikheev, Qingcheng Mao, and Jashvant D. Unadkat

Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course (Fast Forward 28 May 2008)

Christophe D Proulx, Brian J Holleran, Antony A Boucard, Emanuel Escher, Gaetan Guillemette, and Richard Leduc

Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor (Fast Forward 28 May 2008)

Marina Galvez-Peralta, Nga T Dai, Dave A Loegering, Karen Flatten, Stephanie Safgren, Jill Wagner, Matthew M Ames, Larry M Karnitz, and Scott H Kaufmann

Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and SN-38 In Human Carcinoma Cell Lines (Fast Forward 28 May 2008)

Adebowale Adebiyi, Elizabeth M McNally, and Jonathan H Jaggar

Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by KATP Channel Openers (Fast Forward 29 May 2008)

Laura Stanasila, Liliane Abuin, Julien Dey, and Susanna Cotecchia

Different Internalization Properties of the alpha1a and alpha1b-Adrenergic Receptor Subytpes: The Potential Role of Receptor Interaction with beta Arrestins and AP50 (Fast Forward 3 June 2008)

Michael H. Court, Suwagmani Hazarika, Soundararajan Krishnaswamy, Moshe Finel, and J. Andrew Williams

Novel Polymorphic Human UDP-glucuronosyltransferase (UGT) 2A3: Cloning, Functional Characterization Of Enzyme Variants, Comparative Tissue Expression, and Gene Induction (Fast Forward 3 June 2008)

Helen H. W. Chen, Im-sook Song, Anwar Hossain, Min-Koo Choi, Yoshiaki Yamane, Zheng D. Liang, Jia Lu, Lily Y Wu, Zahid Siddik, leo W. J. Klomp, Naramol Savaraj, and Macus T. Kuo

Elevated Glutathione Levels Confers Cellular Sensitization to Cisplatin Toxicity by Upregulation of Copper Transporter hCtr1. (Fast Forward 3 June 2008)

Ohad Mazor, Ofer Cohen, Chanoch Kronman, Lily Raveh, Dana Stein, Arie Ordentlich, and Avigdor Shafferman

Aging-Resistant Organophosphate Bioscavenger Based on PEGylated Phe338Ala Human Acetylcholinesterase (Fast Forward 3 June 2008)

Julius Militante, Bei-Wen Ma, Gustav Akk, and Joseph H. Steinbach

Activation and Block of the Adult Muscle-Type Nicotinic Receptor by Physostigmine: Single-Channel Studies (Fast Forward 3 June 2008)

Stewart M Knoepp, Manpreet S Chahal, Yuhuan Xie, Zhihong Zhang, Daniel J Brauner, Mark A Hallman, Stephanie A Robinson, Shujie Han, Masaki Imai, Stephen Tomlinson, and Kathryn E Meier

Effects of Active and Inactive Phospholipase D2 on Signal Transduction, Adhesion, Migration, Invasion, and Metastasis in EL4 Lymphoma Cells (Fast Forward 3 June 2008)

Isabelle Bar, Pieter-Jan Guns, Jessica Metallo, Dorothee Cammarata, Francoise Wilkin, Jean-Marie Boeynaems, Hidde Bult, and Bernard Robaye

Knock-Out Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells (Fast Forward 3 June 2008)

Louis-Philippe Bernier, Ariel R. Ase, Xinkang Tong, Edith Hamel, Dominique Blais, Qi Zhao, Diomedes Logothetis, and Philippe Seguela

Direct Modulation of P2X1 Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate (Fast Forward 3 June 2008)

Lawrence S. Barak, Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron, and Raul R. Gainetdinov

Pharmacological Characterization of Membrane-Expressed Human Trace Amine Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer (BRET) cAMP Biosensor (Fast Forward 4 June 2008)

Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas, and I. David Goldman

The Proton-Coupled Folate Transporter (PCFT): Impact on Pemetrexed Transport and on Antifolates Activities as Compared to the Reduced Folate Carrier (Fast Forward 4 June 2008)

Yi-He Ling, Ruoping Lin, and Roman Perez-Soler

Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small Cell Lung Cancer Cells with EGFRL858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of Bax and Bak (Fast Forward 4 June 2008)

Rama Panford-Walsh, Wibke Singer, Lukas Ruttiger, Saida Hadjab, Justin Tan, Hyun-Soon Geisler, Ulrike Zimmermann, Iris Kopschall, Karin Rohbock, Anna Vieljans, Elmar Oestreicher, and Marlies Knipper

Midazolam Reverses Salicylate Induced Changes in BDNF and Arg3.1 Expression: Implications for Tinnitus Perception and Auditory Plasticity (Fast Forward 4 June 2008)

Sheryl A Flanagan, Christina M Krokosky, Sudha Mannava, Mikhail A Nikiforov, and Donna S Shewach

MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches (Fast Forward 5 June 2008)

Rosalind Mann, Mark J. Wigglesworth, and Dan Donnelly

Ligand-Receptor Interactions at the Parathyroid Hormone (PTH) Receptors: Subtype Binding Selectivity Is Mediated Via an Interaction Between Residue 23 on the Ligand and Residue 41 on the Receptor (Fast Forward 6 June 2008)

Yun Ge, Jung S. Byun, Paola De Luca, Geraldine Gueron, Quentin Q Li, Idalia M. Yabe, Sara G. Sadiq-Ali, William D Figg, Jesse Quintero, Cynthia M Haggerty, Adriana De Siervi, and Kevin Gardner

Combinatorial Anti-Leukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide CPS49 and Flavopiridol (Fast Forward 12 June 2008)

Gustav Akk, Ping Li, John Bracamontes, David E Reichert, Douglas F Covey, and Joseph H. Steinbach

Mutations of the GABA-A Receptor alpha1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids (Fast Forward 10 June 2008)

Aditi P Martin, Anna Miller, Luni Emdad, Mohammed Rahmani, Teneille Walker, Clint Mitchell, Michael P Hagan, Margaret A Park, Adly Yacoub, Paul B Fisher, Steven Grant, and Paul Dent

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression, Decreased BAK Activation, and not by ERBB Receptor Mutation (Fast Forward 10 June 2008)

Isamu Aiba, Anwar Hossain, and Macus Tien Kuo

Elevated GSH Level Increases Cadmium Resistance through Downregulation of Sp1-Dependent Expression of Cadmium Transporter ZIP8 (Fast Forward 12 June 2008)

Jianxi Liu, Thirumalini Vaithianathan, Kandiah Manivannan, Abby Parrill, and Alex M Dopico

Ethanol Modulates BKCa Channels by Acting as An Adjuvant of Calcium (Fast Forward 13 June 2008)

Dar'ya S. Redka, Luca F. Pisterzi, and James W. Wells

Binding of Orthosteric Ligands to the Allosteric Site of the M2 Muscarinic Cholinergic Receptor (Fast Forward 13 June 2008)

Sailesh Surapureddi, Ritu Rana, Janardan K Reddy, and Joyce A Goldstein

The Coactivator NCOA6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4alpha (Fast Forward 13 June 2008)

Lisa Mathiasen, Daniel M. Dupont, Anni Christensen, Grant E. Blouse, Jan K. Jensen, Ann Gils, Paul J. Declerck, Troels Wind, and Peter A. Andreasen

A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State (Fast Forward 23 June 2008)

Frederick S. Jones, Jie Jing, Anthony H. Stonehouse, Anthony Stevens, and Gerald M. Edelman

Caffeine Stimulates Cytochrome Oxidase Expression and Activity in the Striatum in a Sexually-Dimorphic Manner (Fast Forward 26 June 2008)

David Marsolais, Bumsuk Hahm, Kurt H Edelmann, Kevin B Walsh, Miguel Guerrero, Yosuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B Oldstone, and Hugh Rosen

Local Not Systemic Modulation Of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses To Influenza (Fast Forward 24 June 2008)

Federica Fala, William L. Blalock, PierLuigi Tazzari, Alessandra Cappellini, Francesca Chiarini, Giovanni Martinelli, Agostino Tafuri, James A. McCubrey, Lucio Cocco, and Alberto M Martelli

Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor, A443654, in T-Acute Lymphoblastic Leukemia (Fast Forward 24 June 2008)

Andrea L Kasinski, Yuhong Du, Shala L Thomas, Jing Zhao, Shi-Yong Sun, Fadlo R Khuri, Cun-Yu Wang, Mamoru Shoji, Aiming Sun, James P Snyder, Dennis Liotta, and Haian Fu

Inhibition of IKK-NF-kappaB Signaling Pathway by EF24, a Novel Monoketone Analogue of Curcumin (Fast Forward 24 June 2008)

Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, Joseph Gal, Lajos Gera, William J Welsh, Kenneth Bachmann, and Sridhar Mani

Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists (Fast Forward 24 June 2008)

Dharini van der Hoeven, Tina C. Wan, and John A. Auchampach

Activation of the A3 Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils (Fast Forward 26 June 2008)

Xiomara A Perez, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady, and Maryka Quik

Chronic Nicotine Treatment Differentially Regulates Striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR Expression and Function (Fast Forward 26 June 2008)

Patrice M. Mich, and William A. Horne

Alternative Splicing of the Ca2+ Channel beta4 Subunit Confers Gabapentin Specificity for Inhibition of Cav2.1 Trafficking (Fast Forward 26 June 2008)