RT Journal Article
SR Electronic
T1 Comparative Inhibitory Action of D- and L-Tryptophan on the Effect of <em>d</em>-Lysergic Acid Diethylamide <em>in Vitro</em>
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 68
OP 77
VO 10
IS 1
A1 JEFFREY L. WINKELHAKE
A1 EDWARD W. VOSS, JR.
A1 DENNIS E. LOPATIN
YR 1974
UL http://molpharm.aspetjournals.org/content/10/1/68.abstract
AB The incorporation in vitro of d-[3H]lysergic acid diethylamide into secreted protein from hyperimmune rabbit lymphoid cells was inhibited by both D- and L-tryptophan. The inhibition was specific for tryptophan isomers and analogues. On the basis of these findings a pathway was formulated to describe the preliminary steps culminating in the covalent incorporation of lysergic acid diethylamide into synthesized protein.