RT Journal Article
SR Electronic
T1 Anti-inflammatory Steroids and Collagen Metabolism: Glucocorticoid-Mediated Decrease of Prolyl Hydroxylase
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 44
OP 51
VO 11
IS 1
A1 KENNETH R. CUTRONEO
A1 FRANS L. H. STASSEN
A1 GEORGE J. CARDINALE
YR 1975
UL http://molpharm.aspetjournals.org/content/11/1/44.abstract
AB Administration of triamcinolone diacetate to rats results in a decrease of prolyl hydroxylase activity in organs from animals of different ages. The response of the enzyme activity is dose-dependent, reversible, independent of endocrine function (except for the response of the liver enzyme in hypophysectomized rats), and dependent on the number of daily injections. The decrease in enzyme activity is paralleled by a decrease in the amount of enzyme protein as measured by immunoassay. These results indicate that prolyl hydroxylase is decreased in a wide spectrum of tissues following administration of anti-inflammatory steroids. Furthermore, these findings suggest that one of the effects of this class of therapeutically used drugs on connective tissue metabolism may be mediated by a decrease in the prolyl hydroxylation step of collagen biosynthesis.