RT Journal Article
SR Electronic
T1 Evidence That Dopamine Is Not a Substrate for Adrenal Phenylethanolamine <em>N</em>-Methyltransferase
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 232
OP 235
VO 11
IS 2
A1 ROBERT G. PENDLETON
A1 GEORGE GESSNER
YR 1975
UL http://molpharm.aspetjournals.org/content/11/2/232.abstract
AB We found that dopamine is not a substrate for adrenal phenylethanolamine N-methyltransferase in vitro at concentrations from 1 µM to 10 mM, using both the bovine and the rabbit adrenal enzyme. In the adrenal glands of intact rats, [3H]dopamine was rapidly converted to [3H]norepinephrine and subsequently to [3H]epinephrine. No significant levels of [3H]epinine were detected.