PT  - JOURNAL ARTICLE
AU  - PER H. ROSENBERG
AU  - HANSJÖRG EIBL
AU  - ANTON STIER
TI  - Biphasic Effects of Halothane on Phospholipid and Synaptic Plasma Membranes: a Spin Label Study
DP  - 1975 Nov 01
TA  - Molecular Pharmacology
PG  - 879--882
VI  - 11
IP  - 6
4099  - http://molpharm.aspetjournals.org/content/11/6/879.short
4100  - http://molpharm.aspetjournals.org/content/11/6/879.full
SO  - Mol Pharmacol1975 Nov 01; 11
AB  - Halothane at 0.16 and 0.32 mM increased, while at 9.3 mM it decreased, the order parameter in palmitoyllauroyllecithin vesicles containing stearic acid spin label I(12,3). A corresponding effect was seen in rat brain synaptic plasma membranes. In dipalmitoyllecithin vesicles the lateral diffusion of stearic acid spin label I(5,10) was inhibited by halothane at 0.32-1.60 mM and promoted by it at 9.3 mM. Halothane in these three membrane systems exerted a biphasic effect, low concentrations ordering and high concentrations disordering the lipid structure of the membranes. ACKNOWLEDGMENTS We thank Dr. W. Kühnle for the synthesis of androstane spin label.