PT  - JOURNAL ARTICLE
AU  - ANNE K. KREY
AU  - JOHN G. OLENICK
AU  - FRED E. HAHN
TI  - Interactions of the Antibiotic Distamycin A with Homopolymeric Single-Stranded Polydeoxyribonucleotides and with ΦX 174 Deoxyribonucleic Acid
DP  - 1976 Jan 01
TA  - Molecular Pharmacology
PG  - 185--190
VI  - 12
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/12/1/185.short
4100  - http://molpharm.aspetjournals.org/content/12/1/185.full
SO  - Mol Pharmacol1976 Jan 01; 12
AB  - The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG, and poly dC and also by ΦX 174 DNA. Poly dA and, to a lesser extent, poly dG induced a Cotton effect in the optical rotatory dispersion spectrum of distamycin A. The complex of distamycin A and ΦX 174 DNA showed a reverisble cooperative transition upon heating and cooling. Distamycin A inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro.