RT Journal Article
SR Electronic
T1 Interactions of the Antibiotic Distamycin A with Homopolymeric Single-Stranded Polydeoxyribonucleotides and with ΦX 174 Deoxyribonucleic Acid
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 185
OP 190
VO 12
IS 1
A1 ANNE K. KREY
A1 JOHN G. OLENICK
A1 FRED E. HAHN
YR 1976
UL http://molpharm.aspetjournals.org/content/12/1/185.abstract
AB The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG, and poly dC and also by ΦX 174 DNA. Poly dA and, to a lesser extent, poly dG induced a Cotton effect in the optical rotatory dispersion spectrum of distamycin A. The complex of distamycin A and ΦX 174 DNA showed a reverisble cooperative transition upon heating and cooling. Distamycin A inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro.