TY - JOUR T1 - On the Mechanism of Oxidative Cleavage of Aryl-Alkyl Ethers by Liver Microsomes JF - Molecular Pharmacology JO - Mol Pharmacol SP - 145 LP - 148 VL - 1 IS - 2 AU - JEAN RENSON AU - HERBERT WEISSBACH AU - SIDNEY UDENFRIEND Y1 - 1965/09/01 UR - http://molpharm.aspetjournals.org/content/1/2/145.abstract N2 - Studies with 18O2 and H218O have shown that oxidative O-demethylation of p-methoxyacetanilide by liver microsomes involves the cleavage of the oxygen methyl bond with no incorporation of oxygen into the phenolic product. They indicate that the intact methoxy group is not displaced by a hydroxyl group. Furthermore, p-methoxyphenylalanine was not converted to tyrosine by liver phenylalanine hydroxylase. These findings indicate that the microsomal cleavage of aryl-alkyl ethers is not catalyzed by an aromatic hydroxylase. ER -