TY - JOUR T1 - Reversible Binding of Chlorpromazine to Brain Tubulin JF - Molecular Pharmacology JO - Mol Pharmacol SP - 769 LP - 777 VL - 12 IS - 5 AU - NORMAN D. HINMAN AU - JOHN R. CANN Y1 - 1976/09/01 UR - http://molpharm.aspetjournals.org/content/12/5/769.abstract N2 - Chlorpromazine binds reversibly to brain tubulin via two well-resolved processes. One chlorpromazine molecule binds strongly compared with 8-9 molecules that bind weakly. Binding to the higher-affinity site is chiefly entropy-driven, implicating hydrophobic forces. The two binding processes are compared with the biological activities of chlorpromazine in vitro. ACKNOWLEDGMENT The authors thank Mr. Robert O. Coombs for technical assistance. ER -