TY - JOUR T1 - Molecular Connectivity and Structure-Activity Relationship of General Anesthetics JF - Molecular Pharmacology JO - Mol Pharmacol SP - 31 LP - 37 VL - 13 IS - 1 AU - THÉRÈSE DI PAOLO AU - LEMONT B. KIER AU - LOWELL H. HALL Y1 - 1977/01/01 UR - http://molpharm.aspetjournals.org/content/13/1/31.abstract N2 - Molecular connectivity indices were calculated for 28 inhalation anesthetics. An excellent correlation is obtained between the relative anesthetic potency and the molecular connectivity index 0χ[unknown] in addition to the charge QH on the polar hydrogens. This quantitative structure-activity relationship accounts for and quantifies previous observations on general anesthetics. Our structure-activity relationship is discussed briefly in relation to theories of general anesthesia. ER -