%0 Journal Article %A STEVEN P. WILSON %A NORMAN KIRSHNER %T Localization of Adenylate Cyclase in Adrenal Medulla %D 1977 %J Molecular Pharmacology %P 382-385 %V 13 %N 2 %X The localization of adenylate cyclase in bovine adrenal medulla was explored using a continuous sucrose density gradient to separate the various subcellular components of this tissue. The results indicate that adenylate cyclase is not a component of chromaffin vesicle membranes as reported earlier by Zinder et al. [(1976) J. Biol. Chem., 251, 2179-2181]. Adenylate cyclase activity observed in chromaffin vesicle membrane fractions is most likely due to contamination by plasma membranes. ACKNOWLEDGMENT The authors thank Mrs. Dorothy Kamin for performing the catecholamine determinations. %U https://molpharm.aspetjournals.org/content/molpharm/13/2/382.full.pdf