TY - JOUR T1 - Metabolism of Trichloroethylene in Liver Microsomes JF - Molecular Pharmacology JO - Mol Pharmacol SP - 239 LP - 246 VL - 1 IS - 3 AU - KENNETH C. LEIBMAN Y1 - 1965/11/01 UR - http://molpharm.aspetjournals.org/content/1/3/239.abstract N2 - The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described. ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124. ER -