%0 Journal Article %A PETER W. F. FISCHER %A JANET K. STEPHENS %A G. S. MARKS %T Effect of Varying the Insulin to Glucagon Ratio on Porphyrin Biosynthesis in Chick Embryo Liver Cells %D 1978 %J Molecular Pharmacology %P 717-721 %V 14 %N 4 %X Allylisopropylacetamide-induced porphyrin accumulation in chick embryo liver cells depends upon the insulin to glucagon ratio. A low level of porphyrin accumulation occurs at insulin to glucagon ratios similar to those found following glucose administration in vivo, suggesting a possible explanation for the therapeutic effect of glucose in hepatic porphyria. ACKNOWLEDGMENT The authors thank Mrs. Frances Taylor for her skillful technical assistance. %U https://molpharm.aspetjournals.org/content/molpharm/14/4/717.full.pdf