@article {WEISS1148, author = {ERICH WEISS and PETER C. HEINRICH}, title = {The Effect of Inhibitors of Transcription and Translation on Chromosomal Proteins}, volume = {14}, number = {6}, pages = {1148--1155}, year = {1978}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {After the administration of actinomycin D, α-amanitin and D-galactosamine, the [3H]-leucine incorporation into total rat liver proteins and into nonhistone chromosomal proteins decreased to about 50\% and 20\% of controls, respectively. At a low dose of cycloheximide the [3H]leucine incorporation into nonhistone chromosomal proteins was unaffected, while the incorporation into total liver proteins was decreased to 35\% of controls. The nonhistone chromosomal protein to DNA ratios changed to 94\%, 78\%, 149\% and 66\% of the controls after actinomycin D, α-amanitin, cycloheximide and D-galactosamine, respectively. SDS-polyacrylamide gel electrophoresis showed different changes in the nonhistone chromosomal protein patterns after the administration of actinomycin D, α-amanitin, cycloheximide and D-galactosamine. The findings are discussed with respect to possible mechanisms involved in liver cell death.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/14/6/1148}, eprint = {https://molpharm.aspetjournals.org/content/14/6/1148.full.pdf}, journal = {Molecular Pharmacology} }