TY - JOUR T1 - The Effect of Inhibitors of Transcription and Translation on Chromosomal Proteins JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1148 LP - 1155 VL - 14 IS - 6 AU - ERICH WEISS AU - PETER C. HEINRICH Y1 - 1978/11/01 UR - http://molpharm.aspetjournals.org/content/14/6/1148.abstract N2 - After the administration of actinomycin D, α-amanitin and D-galactosamine, the [3H]-leucine incorporation into total rat liver proteins and into nonhistone chromosomal proteins decreased to about 50% and 20% of controls, respectively. At a low dose of cycloheximide the [3H]leucine incorporation into nonhistone chromosomal proteins was unaffected, while the incorporation into total liver proteins was decreased to 35% of controls. The nonhistone chromosomal protein to DNA ratios changed to 94%, 78%, 149% and 66% of the controls after actinomycin D, α-amanitin, cycloheximide and D-galactosamine, respectively. SDS-polyacrylamide gel electrophoresis showed different changes in the nonhistone chromosomal protein patterns after the administration of actinomycin D, α-amanitin, cycloheximide and D-galactosamine. The findings are discussed with respect to possible mechanisms involved in liver cell death. ER -