TY - JOUR T1 - Inhibition of Sodium Channels by D600 JF - Molecular Pharmacology JO - Mol Pharmacol SP - 174 LP - 178 VL - 15 IS - 1 AU - JONAS B. GALPER AU - WILLIAM A. CATTERALL Y1 - 1979/01/01 UR - http://molpharm.aspetjournals.org/content/15/1/174.abstract N2 - D6OO, an inhibitor of the slow inward Ca++/Na+ current during the plateau phase of the cardiac action potential, also inhibits veratridine-activated fast sodium channels in both cultured heart cells and cultured neuroblastoma cells. The inhibition is competitive with respect to veratridine and is antagonized by Ca++. The KI for D600 in the presence of 1.8 mM Ca++ is approximately 3 µM. ER -