TY - JOUR T1 - Modification of Acetylcholine Receptor-Mediated Ion Permeability by Thiamine JF - Molecular Pharmacology JO - Mol Pharmacol SP - 747 LP - 750 VL - 15 IS - 3 AU - DANIEL R. DOERGE AU - MARK G. MCNAMEE AU - LLOYD L. INGRAHAM Y1 - 1979/05/01 UR - http://molpharm.aspetjournals.org/content/15/3/747.abstract N2 - Thiamine has been found to be active in an acetylcholine receptor-rich postsynaptic membrane preparation from Torpedo californica electroplax by inhibiting the rate of carbamylcholine-induced acetylcholine receptor-mediated 22Na efflux. Thiamine reduces the maximal response to carbamylcholine without changing the affinity of the receptor for carbamylcholine. ER -