RT Journal Article
SR Electronic
T1 Modification of Acetylcholine Receptor-Mediated Ion Permeability by Thiamine
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 747
OP 750
VO 15
IS 3
A1 DOERGE, DANIEL R.
A1 MCNAMEE, MARK G.
A1 INGRAHAM, LLOYD L.
YR 1979
UL http://molpharm.aspetjournals.org/content/15/3/747.abstract
AB Thiamine has been found to be active in an acetylcholine receptor-rich postsynaptic membrane preparation from Torpedo californica electroplax by inhibiting the rate of carbamylcholine-induced acetylcholine receptor-mediated 22Na efflux. Thiamine reduces the maximal response to carbamylcholine without changing the affinity of the receptor for carbamylcholine.