RT Journal Article SR Electronic T1 Spin Trapping of the Primary Radical Involved in the Activation of the Carcinogen N-Hydroxy-2-acetylaminofluorene by Cumene Hydroperoxide-Hematin JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 233 OP 238 VO 17 IS 2 A1 GERALD M. ROSEN A1 ELMER J. RAUCKMAN YR 1980 UL http://molpharm.aspetjournals.org/content/17/2/233.abstract AB We have verified that the cumene hydroperoxide-hematin system reacts with 5,5-dimethyl-1-pyrroline-1-oxide to form the nitroxide 5,5-dimethyl-pyrrolidone-(2)-oxyl-(1) (DMPOX). We have investigated the mechanism of this reaction and found that it is not a simple oxidation, as has been previously reported, but that DMPOX is formed via the spin trapping of a cumene hydroperoxyl radical followed by an intramolecular carbanion displacement. The activation of the carcinogen, N-hydroxyl-2-acetylaminofluorene, by the cumene hydroperoxide-hematin system is most likely mediated by cumene hydroperoxyl radical.