TY - JOUR T1 - Metabolites from the Reduction of Metronidazole by Xanthine Oxidase JF - Molecular Pharmacology JO - Mol Pharmacol SP - 105 LP - 111 VL - 18 IS - 1 AU - EWAN J. T. CHRYSTAL AU - RONALD L. KOCH AU - PETER GOLDMAN Y1 - 1980/07/01 UR - http://molpharm.aspetjournals.org/content/18/1/105.abstract N2 - Metronidazole is reduced by a variety of electron donors in an in vitro system containing milk xanthine oxidase. With hypoxanthine as electron donor, the products and their yields are as follows: N-(2-hydroxyethyl)-oxamic acid, 2.2%; N-glycoylethanolamine, 2.7%; N-acetylethanolamine, 2.4%; ethanolamine, 15.3%; acetate, 4.8%; acetamide, 14.1%; and glycine, 8%. Additional glycine is found when the reaction products are hydrolyzed. These products are consistent with a number of patterns of fragmentation of the imidazole ring which suggest the existence of several labile intermediates in the reduction of metronidazole. ER -