%0 Journal Article %A ALAN R. P. PATERSON %A EDA Y. LAU %A EWA DAHLIG %A CAROL E. CASS %T A Common Basis for Inhibition of Nucleoside Transport by Dipyridamole and Nitrobenzylthioinosine? %D 1980 %J Molecular Pharmacology %P 40-44 %V 18 %N 1 %X Transport of uridine by monolayer cultures of HeLa cells was inhibited by nitrobenzylthioinosine, dipyridamole, and lidoflazine. Biphasic concentration-effect curves were obtained for inhibition of nucleoside transport by nitrobenzylthioinosine, but not for inhibition by dipyridamole. Dipyridamole and lidoflazine interfered with high-affinity binding of [3H]nitrobenzylthioinosine to HeLa cells in an apparently competitive fashion; values of 1, 30, and 300 nM were obtained for dissociation constants, respectively, for nitrobenzylthioinosine, dipyridamole, and lidoflazine. The apparent competition with nitrobenzylthioinosine at the latter’s high-affinity binding sites suggests that dipyridamole and lidoflazine inhibit nucleoside transport by interaction with these sites. %U https://molpharm.aspetjournals.org/content/molpharm/18/1/40.full.pdf