PT  - JOURNAL ARTICLE
AU  - PAUL J. PREIDECKER
AU  - KRISHNA C. AGRAWAL
AU  - ALAN C. SARTORELLI
AU  - E. COLLEEN MOORE
TI  - Effects of the Ferrous Chelate of 4-Methyl-5-Amino-1-Formylisoquinoline Thiosemicarbazone (MAIQ-1) on the Kinetics of Reduction of CDP by Ribonucleotide Reductase of the Novikoff Tumor
DP  - 1980 Nov 01
TA  - Molecular Pharmacology
PG  - 507--512
VI  - 18
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/18/3/507.short
4100  - http://molpharm.aspetjournals.org/content/18/3/507.full
SO  - Mol Pharmacol1980 Nov 01; 18
AB  - The inhibition of partially purified ribonucleotide reductase (EC 1.17.4.1) from rat tumor by the iron chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) was studied. The chelate was a more effective inhibitor than free MAIQ-1 in the absence of added iron. MAIQ-1(Fe2+) was kinetically noncompetitive with the nucleotide substrate and with Fe2+; it was uncompetitive with thioredoxin, the protein dithiol substrate. ACKNOWLEDGMENT Some of the research is taken from a thesis submitted by Paul Preidecker to the University of Texas Graduate School of Biomedical Sciences at Houston in partial fulfillment of the requirements of the degree of Master of Science in Biomedical Science.