TY - JOUR T1 - Superoxide Production by Purified Hamster Hepatic Nuclei JF - Molecular Pharmacology JO - Mol Pharmacol SP - 588 LP - 593 VL - 18 IS - 3 AU - SUZANNE E. PATTON AU - GERALD M. ROSEN AU - ELMER J. RAUCKMAN Y1 - 1980/11/01 UR - http://molpharm.aspetjournals.org/content/18/3/588.abstract N2 - We have found that hamster hepatic nuclei produce substantial quantities of superoxide in the presence of NADPH. We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dismutase is in equilibrium with cytoplasmic superoxide dismutase. Finally, we have presented evidence which demonstrates that the flavoprotein FAD-monooxygenase is responsible for most of the nuclear superoxide production. ER -