RT Journal Article
SR Electronic
T1 Comparative Flavoprotein Catalysis of Anthracycline Antibiotic
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 184
OP 186
VO 19
IS 1
A1 SU-SHU PAN
A1 LESLIE PEDERSEN
A1 NICHOLAS R. BACHUR
YR 1981
UL http://molpharm.aspetjournals.org/content/19/1/184.abstract
AB Several flavoenzymes are compared for their ability to catalyze reductive glycosidic cleavage of anthracycline antibiotics and to promote oxygen consumption in the presence of the antibiotics. NADPH cytochrome P-450 reductase, xanthine oxidase, nitrate reductase, NADH cytochrome c reductase, and lipoamide dehydrogenase catalyzed with decreasing specific activity the reductive glycosidic cleavage of daunorubicin and showed enhanced oxygen consumption in the presence of daunorubicin. Gluthione reductases, L-amino acid oxidase, D-amino acid oxidase, D-glucose oxidase, and lactic dehydrogenase were inactive. All of those flavoenzymes which catalyze reductive glycosidic cleavage possess single-electron transfer systems. ACKNOWLEDGMENT We wish to thank Ms. Helen Chlewicki in the preparation of the manuscript.