RT Journal Article SR Electronic T1 Micellarization of Chlorpromazine JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 244 OP 245 VO 20 IS 2 A1 JOHN R. CANN A1 LAWRENCE W. NICHOL A1 DONALD J. WINZOR YR 1981 UL http://molpharm.aspetjournals.org/content/20/2/244.abstract AB The micellar characteristics of chlorpromazine in 0.025 M sodium pyrophosphate-0.00125 M magnesium chloride-0.125 M sodium chloride-1.0 M sucrose, pH 6.8, 37°, have been investigated by frontal gel chromatography on Sephadex G-25. Results indicate a critical micelle concentration of 0.2 mM, a value that substantiates the necessity to consider the coexistence of monomeric and micellar forms of the drug in its interaction with tubulin under these conditions. Taken in conjunction with published results of such binding studies, this investigation provides experimental support for the concept that the micellar state of chlorpromazine interacts preferentially with one site on brain tubulin.