TY - JOUR T1 - Conformational Properties of Benzodioxan Derivatives with <em>Alpha</em>-Adrenergic Blocking Activity JF - Molecular Pharmacology JO - Mol Pharmacol SP - 371 LP - 376 VL - 20 IS - 2 AU - ALDO BALSAMO AU - BRUNO MACCHIA AU - FRANCO MACCHIA AU - ADRIANO MARTINELLI AU - PIETRO TOGNETTI AU - CARLO A. VERACINI Y1 - 1981/09/01 UR - http://molpharm.aspetjournals.org/content/20/2/371.abstract N2 - Benzodioxan derivatives active on the alpha-adrenergic receptor are considered. The half-chair equilibrium of the dioxane ring was studied by 1H-NMR spectroscopy for piperoxan X and quiloflex XII. The preferred conformation was also obtained by PCILO calculations for X. The results were evaluated in order to obtain information about the mechanism of the alpha-adrenergic drug-receptor interaction. ER -