PT  - JOURNAL ARTICLE
AU  - H. HAMBOECK
AU  - R. W. FISCHER
AU  - E. E. DI IORIO
AU  - K. H. WINTERHALTER
TI  - The Binding of <em>s</em>-Triazine Metabolites to Rodent Hemoglobins Appears Irrelevant to Other Species
DP  - 1981 Nov 01
TA  - Molecular Pharmacology
PG  - 579--584
VI  - 20
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/20/3/579.short
4100  - http://molpharm.aspetjournals.org/content/20/3/579.full
SO  - Mol Pharmacol1981 Nov 01; 20
AB  - A sulfoxide metabolite of s-triazines binds to Cys β-125 of rat hemoglobin rather than to the usually more reactive Cys β-93, which is present in most mammalian hemoglobins. Hemoglobins from species other than rodents and chicken (Cys β3-126) do not react with the sulfoxide. An attempt to explain this unexpected finding on a stereochemical basis is presented and the general implications of this phenomenon are discussed.