TY - JOUR T1 - The Binding of <em>s</em>-Triazine Metabolites to Rodent Hemoglobins Appears Irrelevant to Other Species JF - Molecular Pharmacology JO - Mol Pharmacol SP - 579 LP - 584 VL - 20 IS - 3 AU - H. HAMBOECK AU - R. W. FISCHER AU - E. E. DI IORIO AU - K. H. WINTERHALTER Y1 - 1981/11/01 UR - http://molpharm.aspetjournals.org/content/20/3/579.abstract N2 - A sulfoxide metabolite of s-triazines binds to Cys β-125 of rat hemoglobin rather than to the usually more reactive Cys β-93, which is present in most mammalian hemoglobins. Hemoglobins from species other than rodents and chicken (Cys β3-126) do not react with the sulfoxide. An attempt to explain this unexpected finding on a stereochemical basis is presented and the general implications of this phenomenon are discussed. ER -