PT  - JOURNAL ARTICLE
AU  - SAM WEISS
AU  - GEORGE I. DRUMMOND
TI  - Dopamine- and Serotonin-Sensitive Adenylate Cyclase in the Gill of <em>Aplysia californica</em>
DP  - 1981 Nov 01
TA  - Molecular Pharmacology
PG  - 592--597
VI  - 20
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/20/3/592.short
4100  - http://molpharm.aspetjournals.org/content/20/3/592.full
SO  - Mol Pharmacol1981 Nov 01; 20
AB  - Stimulation of adenylate cyclase by dopamine and serotonin was examined in a particulate fraction of Aplysia gill homogenates. Dopamine augmented activity 3- to 5-fold (EC50, 10 µM), whereas serotonin increased activity 15- to 20-fold (EC50, 1 µM). Lysergic acid diethylamide and several ergot alkaloids were full or partial agonists for enzyme stimulation. Structure-activity relationships of dopaminergic and serotonergic stimulation and the blocking action of several antagonists suggest that structural similarities exist between the receptors that mediate dopamine and serotonin stimulation of adenylate cyclase. ACKNOWLEDGMENTS The authors thank Dr. Ken Lukowiak and his graduate students, Jeff I. Goldberg and Peter C. Ruben, for providing gill tissue samples and for many thoughtful suggestions throughout the course of the study.