TY - JOUR T1 - Dopamine- and Serotonin-Sensitive Adenylate Cyclase in the Gill of <em>Aplysia californica</em> JF - Molecular Pharmacology JO - Mol Pharmacol SP - 592 LP - 597 VL - 20 IS - 3 AU - SAM WEISS AU - GEORGE I. DRUMMOND Y1 - 1981/11/01 UR - http://molpharm.aspetjournals.org/content/20/3/592.abstract N2 - Stimulation of adenylate cyclase by dopamine and serotonin was examined in a particulate fraction of Aplysia gill homogenates. Dopamine augmented activity 3- to 5-fold (EC50, 10 µM), whereas serotonin increased activity 15- to 20-fold (EC50, 1 µM). Lysergic acid diethylamide and several ergot alkaloids were full or partial agonists for enzyme stimulation. Structure-activity relationships of dopaminergic and serotonergic stimulation and the blocking action of several antagonists suggest that structural similarities exist between the receptors that mediate dopamine and serotonin stimulation of adenylate cyclase. ACKNOWLEDGMENTS The authors thank Dr. Ken Lukowiak and his graduate students, Jeff I. Goldberg and Peter C. Ruben, for providing gill tissue samples and for many thoughtful suggestions throughout the course of the study. ER -