@article {BRESNICK406, author = {EDWARD BRESNICK}, title = {Ribonucleic Acid Polymerase Activity in Liver Nuclei from Rats Pretreated with 3-Methylcholanthrene}, volume = {2}, number = {5}, pages = {406--410}, year = {1966}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The intraperitoneal administration of 3-methylcholanthrene is attended by an increase in RNA polymerase activity in the liver nuclei. The maximal increase is reached between 6 and 12 hr after administration of the agent; enzyme activity returns to control values by 48 hr. The administration of actinomycin D or cycloheximide prevents the rise in nuclear RNA polymerase activity. No increase is apparent when the enzyme is assayed at high salt concentrations, i.e., 0.7 M ammonium sulfate. These data suggest that 3-methylcholanthrene may cause the synthesis of or activate a "derepressor" substance that allows for an increased template activity of the liver chromatin in transcription. ACKNOWLEDGMENT These studies were supported by a grant from the American Cancer Society (E 373).}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/2/5/406}, eprint = {https://molpharm.aspetjournals.org/content/2/5/406.full.pdf}, journal = {Molecular Pharmacology} }