RT Journal Article
SR Electronic
T1 Purification and partial characterization of a daunorubicin-binding protein from rat liver.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 336
OP 340
VO 24
IS 2
A1 R A Gambetta
A1 A Colombo
A1 C Lanzi
A1 F Zunino
YR 1983
UL http://molpharm.aspetjournals.org/content/24/2/336.abstract
AB A daunorubicin-binding protein has been isolated from the soluble fraction of normal rat liver by affinity chromatography on daunorubicin-Sepharose columns. This protein, which apparently binds anthracyclines specifically, appears to be composed of four polypeptides of 54,000 Mr, is different from tubulin, and is not involved in anthracycline metabolism. Its physiological function remains to be determined.