RT Journal Article
SR Electronic
T1 Prevention by Antidepressant Drugs of Reserpine Effect on Pyridine Nucleotide Metabolism
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 347
OP 351
VO 2
IS 4
A1 GERTRUDE P. QUINN
A1 PAUL GREENGARD
A1 MARIA B. REID
YR 1966
UL http://molpharm.aspetjournals.org/content/2/4/347.abstract
AB A variety of structurally unrelated antidepressant drugs, including both monoamine oxidase (MAO)-inhibitors and non-MAO-inhibitors, prevent the effect of reserpine on the nicotinamide-induced increase in NAD. A single injection of imipramine or iproniazid was effective when given at any time up to several days prior to reserpine. In general, compounds other than antidepressants did not prevent the reserpine effect on NAD metabolism. The ability to block the effect of reserpine on NAD metabolism correlated well with the ability to block the sedative effect of reserpine. The antidepressants did not prevent the effect of chlorpromazine on NAD level, in agreement with their lack of effect on the sedative action of chlorpromazine.