RT Journal Article SR Electronic T1 Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system. JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 417 OP 421 VO 31 IS 4 A1 C Mottley A1 K Toy A1 R P Mason YR 1987 UL http://molpharm.aspetjournals.org/content/31/4/417.abstract AB The thiol moiety is prone to oxidative free radical formation, which may be important in mediating the toxicity of some thiol-containing compounds. The oxidation of the compounds cysteine, cysteamine, N-acetylcysteine, glutathione, penicillamine, and captopril were studied using ESR and oxygen uptake techniques. Lactoperoxidase, with hydrogen peroxide to provide oxidizing equivalents, was used to initiate the oxidation. The reaction appears to be strongly peroxide dependent, with either exogenous H2O2 or thiol-derived peroxide driving the reaction.