PT  - JOURNAL ARTICLE
AU  - J. THOMAS
AU  - B. D. ROUFOGALIS
TI  - Structural Specificity of Substrates of Acetylcholinesterase
DP  - 1967 Mar 01
TA  - Molecular Pharmacology
PG  - 103--107
VI  - 3
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/3/2/103.short
4100  - http://molpharm.aspetjournals.org/content/3/2/103.full
SO  - Mol Pharmacol1967 Mar 01; 3
AB  - 1(2-Acetoxyethyl)quinuclidinium iodide has been examined as a substrate of both purified acetylcholinesterase and human serum cholinesterase. Neither enzyme is capable of hydrolyzing it. The inhibition of acetylcholinesterase by the quinuclidine ester has been investigated and the Ki is reported. The stability of the ester toward acetylcholinesterase is discussed in terms of the molecular perturbation theory of drug action. ACKNOWLEDGMENT This investigation was supported in part by grants from the National Health and Medical Research Council of Australia. The authors wish to thank Mr. B. K. Williams for assistance with the chemical work.