RT Journal Article
SR Electronic
T1 The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 715
OP 718
VO 34
IS 6
A1 A J Bean
A1 P D Shepard
A1 B S Bunney
A1 E J Nestler
A1 R H Roth
YR 1988
UL http://molpharm.aspetjournals.org/content/34/6/715.abstract
AB Activation of synthesis-modulating dopamine autoreceptors by dopamine or its agonists has been shown to inhibit dopamine synthesis in the rat striatum. However, systemic administration of the direct-acting dopamine agonist apomorphine failed to inhibit dopamine synthesis in striata from rats that had received local unilateral administration of pertussis toxin. Apomorphine did reduce dopamine synthesis by greater than 50% in sham injected control rats as well as in the striata opposite to the side of pertussis toxin injection. Examination of G proteins in striatal tissue revealed that 61% of the G proteins were ADP-ribosylated in vivo by direct pertussis toxin injection. These data suggest that guanine nucleotide regulatory proteins mediate the effects of activation of striatal synthesis-modulating dopamine autoreceptors.